Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations
BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR a...
Published in: | Environmental Health Perspectives |
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Main Authors: | , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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National Institute of Environmental Health Sciences
2007
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Online Access: | https://lup.lub.lu.se/record/adb58324-3c45-459d-838e-dbdf3be2149d https://doi.org/10.1289/ehp.9352 |
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ftulundlup:oai:lup.lub.lu.se:adb58324-3c45-459d-838e-dbdf3be2149d 2024-01-28T10:06:13+01:00 Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations Toft, Gunnar Long, Manhai Krüger, Tanja Hjelmborg, Philip S. Bonde, Jens Peter Rignell-Hydbom, Anna Tyrkiel, Ewa Hagmar, Lars Giwercman, Aleksander Spanó, Marcello Bizzaro, Davide Pedersen, Henning S. Lesovoy, Vladymir Ludwicki, Jan K. Bonefeld-Jørgensen, Eva C. 2007-12-01 https://lup.lub.lu.se/record/adb58324-3c45-459d-838e-dbdf3be2149d https://doi.org/10.1289/ehp.9352 eng eng National Institute of Environmental Health Sciences https://lup.lub.lu.se/record/adb58324-3c45-459d-838e-dbdf3be2149d http://dx.doi.org/10.1289/ehp.9352 pmid:18174945 scopus:40949160699 Environmental Health Perspectives; 115(SUPPL1), pp 15-20 (2007) ISSN: 0091-6765 Environmental Health and Occupational Health Androgen receptor Aryl hydrocarbon receptor Calux Endocrine disruption Estrogen receptor Human Sperm contributiontojournal/article info:eu-repo/semantics/article text 2007 ftulundlup https://doi.org/10.1289/ehp.9352 2024-01-03T23:29:19Z BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1-79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2-28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2-20) was found. We are unable to exclude that the associations are chance findings. CONCLUSION: Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men. Article in Journal/Newspaper Greenland inuit inuits Lund University Publications (LUP) Greenland Environmental Health Perspectives 115 Suppl 1 15 20 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Androgen receptor Aryl hydrocarbon receptor Calux Endocrine disruption Estrogen receptor Human Sperm |
spellingShingle |
Environmental Health and Occupational Health Androgen receptor Aryl hydrocarbon receptor Calux Endocrine disruption Estrogen receptor Human Sperm Toft, Gunnar Long, Manhai Krüger, Tanja Hjelmborg, Philip S. Bonde, Jens Peter Rignell-Hydbom, Anna Tyrkiel, Ewa Hagmar, Lars Giwercman, Aleksander Spanó, Marcello Bizzaro, Davide Pedersen, Henning S. Lesovoy, Vladymir Ludwicki, Jan K. Bonefeld-Jørgensen, Eva C. Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
topic_facet |
Environmental Health and Occupational Health Androgen receptor Aryl hydrocarbon receptor Calux Endocrine disruption Estrogen receptor Human Sperm |
description |
BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1-79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2-28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2-20) was found. We are unable to exclude that the associations are chance findings. CONCLUSION: Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men. |
format |
Article in Journal/Newspaper |
author |
Toft, Gunnar Long, Manhai Krüger, Tanja Hjelmborg, Philip S. Bonde, Jens Peter Rignell-Hydbom, Anna Tyrkiel, Ewa Hagmar, Lars Giwercman, Aleksander Spanó, Marcello Bizzaro, Davide Pedersen, Henning S. Lesovoy, Vladymir Ludwicki, Jan K. Bonefeld-Jørgensen, Eva C. |
author_facet |
Toft, Gunnar Long, Manhai Krüger, Tanja Hjelmborg, Philip S. Bonde, Jens Peter Rignell-Hydbom, Anna Tyrkiel, Ewa Hagmar, Lars Giwercman, Aleksander Spanó, Marcello Bizzaro, Davide Pedersen, Henning S. Lesovoy, Vladymir Ludwicki, Jan K. Bonefeld-Jørgensen, Eva C. |
author_sort |
Toft, Gunnar |
title |
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
title_short |
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
title_full |
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
title_fullStr |
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
title_full_unstemmed |
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
title_sort |
semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2007 |
url |
https://lup.lub.lu.se/record/adb58324-3c45-459d-838e-dbdf3be2149d https://doi.org/10.1289/ehp.9352 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
Environmental Health Perspectives; 115(SUPPL1), pp 15-20 (2007) ISSN: 0091-6765 |
op_relation |
https://lup.lub.lu.se/record/adb58324-3c45-459d-838e-dbdf3be2149d http://dx.doi.org/10.1289/ehp.9352 pmid:18174945 scopus:40949160699 |
op_doi |
https://doi.org/10.1289/ehp.9352 |
container_title |
Environmental Health Perspectives |
container_volume |
115 |
container_issue |
Suppl 1 |
container_start_page |
15 |
op_container_end_page |
20 |
_version_ |
1789332939422564352 |