Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study
Background: Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to...
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Online Access: | https://lup.lub.lu.se/record/4273111 https://doi.org/10.1371/journal.pone.0081892 https://portal.research.lu.se/files/3453095/4588734 |
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ftulundlup:oai:lup.lub.lu.se:ac70bcc2-a460-4212-8de8-1b9a53e1e4af 2023-05-15T17:45:03+02:00 Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study Kelly, Rachel S. Lundh, Thomas Porta, Miquel Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc 2013 application/pdf https://lup.lub.lu.se/record/4273111 https://doi.org/10.1371/journal.pone.0081892 https://portal.research.lu.se/files/3453095/4588734 eng eng Public Library of Science (PLoS) https://lup.lub.lu.se/record/4273111 http://dx.doi.org/10.1371/journal.pone.0081892 https://portal.research.lu.se/files/3453095/4588734 wos:000327657900059 scopus:84896729242 info:eu-repo/semantics/openAccess PLoS ONE; 8(11) (2013) ISSN: 1932-6203 Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2013 ftulundlup https://doi.org/10.1371/journal.pone.0081892 2023-02-01T23:35:20Z Background: Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma. Methods: 194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-mass spectrometry. Logistic regression was applied to assess the association with risk. Analyses were stratified by cohort and gender and by subtype where possible. Results: There was little evidence of an increased risk of B-cell NHL or multiple myeloma with exposure to Cd (B-cell NHL: OR 1.09 95%CI 0.61, 1.93, MM: OR 1.16 95% CI: 0.40, 3.40) or Pb (B-cell NHL: 0.93 95% CI 0.43, 2.02, multiple myeloma: OR 1.63 95% CI 0.45, 5.94) in the total population when comparing the highest to the lowest quartile of exposure. However, gender and cohort specific differences in results were observed. In females the risk of B-cell NHL was more than doubled in those with a body burden of Cd >1 mu g/L (OR 2.20 95% CI; 1.04, 4.65). Conclusions: This nested case-control study does not support a consistent positive association between Cd or Pb and NHL, but there is some indication of a gender specific effect suggesting further research is warranted. Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) PLoS ONE 8 11 e81892 |
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Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Kelly, Rachel S. Lundh, Thomas Porta, Miquel Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
topic_facet |
Environmental Health and Occupational Health |
description |
Background: Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma. Methods: 194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-mass spectrometry. Logistic regression was applied to assess the association with risk. Analyses were stratified by cohort and gender and by subtype where possible. Results: There was little evidence of an increased risk of B-cell NHL or multiple myeloma with exposure to Cd (B-cell NHL: OR 1.09 95%CI 0.61, 1.93, MM: OR 1.16 95% CI: 0.40, 3.40) or Pb (B-cell NHL: 0.93 95% CI 0.43, 2.02, multiple myeloma: OR 1.63 95% CI 0.45, 5.94) in the total population when comparing the highest to the lowest quartile of exposure. However, gender and cohort specific differences in results were observed. In females the risk of B-cell NHL was more than doubled in those with a body burden of Cd >1 mu g/L (OR 2.20 95% CI; 1.04, 4.65). Conclusions: This nested case-control study does not support a consistent positive association between Cd or Pb and NHL, but there is some indication of a gender specific effect suggesting further research is warranted. |
format |
Article in Journal/Newspaper |
author |
Kelly, Rachel S. Lundh, Thomas Porta, Miquel Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc |
author_facet |
Kelly, Rachel S. Lundh, Thomas Porta, Miquel Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc |
author_sort |
Kelly, Rachel S. |
title |
Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
title_short |
Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
title_full |
Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
title_fullStr |
Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
title_full_unstemmed |
Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin's Lymphoma and Multiple Myeloma: A Nested Case-Control Study |
title_sort |
blood erythrocyte concentrations of cadmium and lead and the risk of b-cell non-hodgkin's lymphoma and multiple myeloma: a nested case-control study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://lup.lub.lu.se/record/4273111 https://doi.org/10.1371/journal.pone.0081892 https://portal.research.lu.se/files/3453095/4588734 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
PLoS ONE; 8(11) (2013) ISSN: 1932-6203 |
op_relation |
https://lup.lub.lu.se/record/4273111 http://dx.doi.org/10.1371/journal.pone.0081892 https://portal.research.lu.se/files/3453095/4588734 wos:000327657900059 scopus:84896729242 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0081892 |
container_title |
PLoS ONE |
container_volume |
8 |
container_issue |
11 |
container_start_page |
e81892 |
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1766147780043079680 |