Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age
We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Gree...
Published in: | Hormones and Behavior |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2018
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Online Access: | https://lup.lub.lu.se/record/a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 https://doi.org/10.1016/j.yhbeh.2017.11.007 |
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ftulundlup:oai:lup.lub.lu.se:a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 2024-04-28T08:21:09+00:00 Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age Høyer, Birgit Bjerre Bonde, Jens Peter Tøttenborg, Sandra Søgaard Ramlau-Hansen, Cecilia Høst Lindh, Christian Pedersen, Henning Sloth Toft, Gunnar 2018 https://lup.lub.lu.se/record/a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 https://doi.org/10.1016/j.yhbeh.2017.11.007 eng eng Elsevier https://lup.lub.lu.se/record/a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 http://dx.doi.org/10.1016/j.yhbeh.2017.11.007 scopus:85044367640 pmid:29133180 Hormones and Behavior; 101, pp 105-112 (2018) ISSN: 0018-506X Environmental Health and Occupational Health Pediatrics Behaviour Child Child development Cohort study Fluorocarbons Prenatal exposure delayed effects contributiontojournal/article info:eu-repo/semantics/article text 2018 ftulundlup https://doi.org/10.1016/j.yhbeh.2017.11.007 2024-04-03T14:05:54Z We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N = 1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Hormones and Behavior 101 105 112 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Pediatrics Behaviour Child Child development Cohort study Fluorocarbons Prenatal exposure delayed effects |
spellingShingle |
Environmental Health and Occupational Health Pediatrics Behaviour Child Child development Cohort study Fluorocarbons Prenatal exposure delayed effects Høyer, Birgit Bjerre Bonde, Jens Peter Tøttenborg, Sandra Søgaard Ramlau-Hansen, Cecilia Høst Lindh, Christian Pedersen, Henning Sloth Toft, Gunnar Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
topic_facet |
Environmental Health and Occupational Health Pediatrics Behaviour Child Child development Cohort study Fluorocarbons Prenatal exposure delayed effects |
description |
We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N = 1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland. |
format |
Article in Journal/Newspaper |
author |
Høyer, Birgit Bjerre Bonde, Jens Peter Tøttenborg, Sandra Søgaard Ramlau-Hansen, Cecilia Høst Lindh, Christian Pedersen, Henning Sloth Toft, Gunnar |
author_facet |
Høyer, Birgit Bjerre Bonde, Jens Peter Tøttenborg, Sandra Søgaard Ramlau-Hansen, Cecilia Høst Lindh, Christian Pedersen, Henning Sloth Toft, Gunnar |
author_sort |
Høyer, Birgit Bjerre |
title |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
title_short |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
title_full |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
title_fullStr |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
title_full_unstemmed |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
title_sort |
exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age |
publisher |
Elsevier |
publishDate |
2018 |
url |
https://lup.lub.lu.se/record/a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 https://doi.org/10.1016/j.yhbeh.2017.11.007 |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Hormones and Behavior; 101, pp 105-112 (2018) ISSN: 0018-506X |
op_relation |
https://lup.lub.lu.se/record/a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2 http://dx.doi.org/10.1016/j.yhbeh.2017.11.007 scopus:85044367640 pmid:29133180 |
op_doi |
https://doi.org/10.1016/j.yhbeh.2017.11.007 |
container_title |
Hormones and Behavior |
container_volume |
101 |
container_start_page |
105 |
op_container_end_page |
112 |
_version_ |
1797583657807904768 |