Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer...
Published in: | International Journal of Cancer |
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Format: | Article in Journal/Newspaper |
Language: | English |
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John Wiley & Sons Inc.
2021
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Online Access: | https://lup.lub.lu.se/record/a4dfab86-e910-4130-96af-8706c82378a5 https://doi.org/10.1002/ijc.33741 |
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ftulundlup:oai:lup.lub.lu.se:a4dfab86-e910-4130-96af-8706c82378a5 2024-05-19T07:42:58+00:00 Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck ALiCCS study group 2021 https://lup.lub.lu.se/record/a4dfab86-e910-4130-96af-8706c82378a5 https://doi.org/10.1002/ijc.33741 eng eng John Wiley & Sons Inc. https://lup.lub.lu.se/record/a4dfab86-e910-4130-96af-8706c82378a5 http://dx.doi.org/10.1002/ijc.33741 scopus:85111998976 pmid:34278568 International Journal of Cancer; 149(11), pp 1863-1876 (2021) ISSN: 0020-7136 Cancer and Oncology ALiCCS childhood cancer late effects skeletal adverse events survivorship contributiontojournal/article info:eu-repo/semantics/article text 2021 ftulundlup https://doi.org/10.1002/ijc.33741 2024-04-23T23:40:16Z The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. Article in Journal/Newspaper Iceland Lund University Publications (LUP) International Journal of Cancer |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology ALiCCS childhood cancer late effects skeletal adverse events survivorship |
spellingShingle |
Cancer and Oncology ALiCCS childhood cancer late effects skeletal adverse events survivorship Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck ALiCCS study group Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
topic_facet |
Cancer and Oncology ALiCCS childhood cancer late effects skeletal adverse events survivorship |
description |
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. |
format |
Article in Journal/Newspaper |
author |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck ALiCCS study group |
author_facet |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck ALiCCS study group |
author_sort |
Oskarsson, Trausti |
title |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_short |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_fullStr |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full_unstemmed |
Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_sort |
skeletal adverse events in childhood cancer survivors : an adult life after childhood cancer in scandinavia cohort study |
publisher |
John Wiley & Sons Inc. |
publishDate |
2021 |
url |
https://lup.lub.lu.se/record/a4dfab86-e910-4130-96af-8706c82378a5 https://doi.org/10.1002/ijc.33741 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer; 149(11), pp 1863-1876 (2021) ISSN: 0020-7136 |
op_relation |
https://lup.lub.lu.se/record/a4dfab86-e910-4130-96af-8706c82378a5 http://dx.doi.org/10.1002/ijc.33741 scopus:85111998976 pmid:34278568 |
op_doi |
https://doi.org/10.1002/ijc.33741 |
container_title |
International Journal of Cancer |
_version_ |
1799482668030623744 |