Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study
Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity? The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure. PFOS and PFOA are persistent man-made chemicals. Experimental animal s...
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Oxford University Press
2014
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Online Access: | https://lup.lub.lu.se/record/4376399 https://doi.org/10.1093/humrep/det390 |
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ftulundlup:oai:lup.lub.lu.se:9c4ca1bf-04b5-47cb-87d2-b172ab53728d 2023-05-15T16:27:47+02:00 Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study Lyngso, J. Ramlau-Hansen, C. H. Hoyer, B. B. Stovring, H. Bonde, J. P. Jönsson, Bo A Lindh, Christian Pedersen, H. S. Ludwicki, J. K. Zviezdai, V. Toft, G. 2014 https://lup.lub.lu.se/record/4376399 https://doi.org/10.1093/humrep/det390 eng eng Oxford University Press https://lup.lub.lu.se/record/4376399 http://dx.doi.org/10.1093/humrep/det390 wos:000330842800021 scopus:84893152983 pmid:24163265 Human Reproduction; 29(2), pp 359-367 (2014) ISSN: 0268-1161 Environmental Health and Occupational Health menstrual cycle PFOS PFOA contributiontojournal/article info:eu-repo/semantics/article text 2014 ftulundlup https://doi.org/10.1093/humrep/det390 2023-02-01T23:29:01Z Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity? The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure. PFOS and PFOA are persistent man-made chemicals. Experimental animal studies suggest they are reproductive toxicants but epidemiological findings are inconsistent. A cross-sectional study including 1623 pregnant women from the INUENDO cohort enrolled during antenatal care visits between June 2002 and May 2004 in Greenland, Poland and Ukraine. Information on menstrual cycle characteristics was obtained by questionnaires together with a blood sample from each pregnant woman. Serum concentrations of PFOS and PFOA were measured by liquid chromatography tandem mass spectrometry. Multiple imputations were performed to account for missing data. The association between PFOS/PFOA and menstrual cycle length (short cycle: 24 days, long cycle: 32 days) and irregularities (7 days in difference between cycles) was analyzed using logistic regression with tertiles of exposure. Estimates are given as adjusted odds ratios (ORs) with 95 confidence intervals (CIs). Higher exposure levels of PFOA were associated with longer menstrual cycles in pooled estimates of all three countries. Compared with women in the lowest exposure tertile, the adjusted OR of long cycles was 1.8 (95 CI: 1.0; 3.3) among women in the highest tertile of PFOA exposure. No significant associations were observed between PFOS exposure and menstrual cycle characteristics. However, we observed a tendency toward more irregular cycles with higher exposure to PFOS [OR 1.7 (95 CI: 0.8; 3.5)]. The overall response rate was 45.3 with considerable variation between countries (91.3 in Greenland, 69.1 in Poland and 26.3 in Ukraine). Possible limitations in our study include varying participation rates across countries; a selected study group overrepresenting the most fertile part of the population; retrospective information on menstrual cycle ... Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland Human Reproduction 29 2 359 367 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health menstrual cycle PFOS PFOA |
spellingShingle |
Environmental Health and Occupational Health menstrual cycle PFOS PFOA Lyngso, J. Ramlau-Hansen, C. H. Hoyer, B. B. Stovring, H. Bonde, J. P. Jönsson, Bo A Lindh, Christian Pedersen, H. S. Ludwicki, J. K. Zviezdai, V. Toft, G. Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
topic_facet |
Environmental Health and Occupational Health menstrual cycle PFOS PFOA |
description |
Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity? The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure. PFOS and PFOA are persistent man-made chemicals. Experimental animal studies suggest they are reproductive toxicants but epidemiological findings are inconsistent. A cross-sectional study including 1623 pregnant women from the INUENDO cohort enrolled during antenatal care visits between June 2002 and May 2004 in Greenland, Poland and Ukraine. Information on menstrual cycle characteristics was obtained by questionnaires together with a blood sample from each pregnant woman. Serum concentrations of PFOS and PFOA were measured by liquid chromatography tandem mass spectrometry. Multiple imputations were performed to account for missing data. The association between PFOS/PFOA and menstrual cycle length (short cycle: 24 days, long cycle: 32 days) and irregularities (7 days in difference between cycles) was analyzed using logistic regression with tertiles of exposure. Estimates are given as adjusted odds ratios (ORs) with 95 confidence intervals (CIs). Higher exposure levels of PFOA were associated with longer menstrual cycles in pooled estimates of all three countries. Compared with women in the lowest exposure tertile, the adjusted OR of long cycles was 1.8 (95 CI: 1.0; 3.3) among women in the highest tertile of PFOA exposure. No significant associations were observed between PFOS exposure and menstrual cycle characteristics. However, we observed a tendency toward more irregular cycles with higher exposure to PFOS [OR 1.7 (95 CI: 0.8; 3.5)]. The overall response rate was 45.3 with considerable variation between countries (91.3 in Greenland, 69.1 in Poland and 26.3 in Ukraine). Possible limitations in our study include varying participation rates across countries; a selected study group overrepresenting the most fertile part of the population; retrospective information on menstrual cycle ... |
format |
Article in Journal/Newspaper |
author |
Lyngso, J. Ramlau-Hansen, C. H. Hoyer, B. B. Stovring, H. Bonde, J. P. Jönsson, Bo A Lindh, Christian Pedersen, H. S. Ludwicki, J. K. Zviezdai, V. Toft, G. |
author_facet |
Lyngso, J. Ramlau-Hansen, C. H. Hoyer, B. B. Stovring, H. Bonde, J. P. Jönsson, Bo A Lindh, Christian Pedersen, H. S. Ludwicki, J. K. Zviezdai, V. Toft, G. |
author_sort |
Lyngso, J. |
title |
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
title_short |
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
title_full |
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
title_fullStr |
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
title_full_unstemmed |
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study |
title_sort |
menstrual cycle characteristics in fertile women from greenland, poland and ukraine exposed to perfluorinated chemicals: a cross-sectional study |
publisher |
Oxford University Press |
publishDate |
2014 |
url |
https://lup.lub.lu.se/record/4376399 https://doi.org/10.1093/humrep/det390 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Human Reproduction; 29(2), pp 359-367 (2014) ISSN: 0268-1161 |
op_relation |
https://lup.lub.lu.se/record/4376399 http://dx.doi.org/10.1093/humrep/det390 wos:000330842800021 scopus:84893152983 pmid:24163265 |
op_doi |
https://doi.org/10.1093/humrep/det390 |
container_title |
Human Reproduction |
container_volume |
29 |
container_issue |
2 |
container_start_page |
359 |
op_container_end_page |
367 |
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1766017294537850880 |