Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review
The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have effectively kept lower antibiotic-resistant bacterial (ARB) pathogen rates than many other countries. However, in recent years, these five countries have encountered a rise in ARB cases and challenges in treating infections du...
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Elsevier
2024
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Online Access: | https://lup.lub.lu.se/record/8d86a9e4-d9d4-4f06-893b-1ab2d193dedb https://doi.org/10.1016/j.envres.2023.118052 |
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ftulundlup:oai:lup.lub.lu.se:8d86a9e4-d9d4-4f06-893b-1ab2d193dedb 2024-05-19T07:42:59+00:00 Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review Tiwari, Ananda Krolicka, Adriana Tran, Tam T. Räisänen, Kati Ásmundsdóttir, Ásta Margrét Wikmark, Odd Gunnar Lood, Rolf Pitkänen, Tarja 2024-04-01 https://lup.lub.lu.se/record/8d86a9e4-d9d4-4f06-893b-1ab2d193dedb https://doi.org/10.1016/j.envres.2023.118052 eng eng Elsevier https://lup.lub.lu.se/record/8d86a9e4-d9d4-4f06-893b-1ab2d193dedb http://dx.doi.org/10.1016/j.envres.2023.118052 scopus:85182021488 pmid:38163547 Environmental Research; 246, no 118052 (2024) ISSN: 0013-9351 Infectious Medicine Antibiotic resistance Carbapenemase-producing Enterobacterales Clinical surveillance Extended-spectrum beta-lactamase Nordic Vancomycin-resistant Enterococcus contributiontojournal/systematicreview info:eu-repo/semantics/article text 2024 ftulundlup https://doi.org/10.1016/j.envres.2023.118052 2024-04-24T00:00:42Z The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have effectively kept lower antibiotic-resistant bacterial (ARB) pathogen rates than many other countries. However, in recent years, these five countries have encountered a rise in ARB cases and challenges in treating infections due to the growing prevalence of ARB pathogens. Wastewater-based surveillance (WBS) is a valuable supplement to clinical methods for ARB surveillance, but there is a lack of comprehensive understanding of WBS application for ARB in the Nordic countries. This review aims to compile the latest state-of-the-art developments in WBS for ARB monitoring in the Nordic countries and compare them with clinical surveillance practices. After reviewing 1480 papers from the primary search, 54 were found relevant, and 15 additional WBS-related papers were included. Among 69 studies analyzed, 42 dedicated clinical epidemiology, while 27 focused on wastewater monitoring. The PRISMA review of the literature revealed that Nordic countries focus on four major WBS objectives of ARB: assessing ARB in the human population, identifying ARB evading wastewater treatment, quantifying removal rates, and evaluating potential ARB evolution during the treatment process. In both clinical and wastewater contexts, the most studied targets were pathogens producing carbapenemase and extended-spectrum beta-lactamase (ESBL), primarily Escherichia coli and Klebsiella spp. However, vancomycin-resistant Enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) have received more attention in clinical epidemiology than in wastewater studies, probably due to their lower detection rates in wastewater. Clinical surveillance has mostly used culturing, antibiotic susceptibility testing, and genotyping, but WBS employed PCR-based and metagenomics alongside culture-based techniques. Imported cases resulting from international travel and hospitalization abroad appear to have frequently contributed to the rise in ARB pathogen cases in these countries. ... Article in Journal/Newspaper Iceland Lund University Publications (LUP) Environmental Research 246 118052 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Infectious Medicine Antibiotic resistance Carbapenemase-producing Enterobacterales Clinical surveillance Extended-spectrum beta-lactamase Nordic Vancomycin-resistant Enterococcus |
spellingShingle |
Infectious Medicine Antibiotic resistance Carbapenemase-producing Enterobacterales Clinical surveillance Extended-spectrum beta-lactamase Nordic Vancomycin-resistant Enterococcus Tiwari, Ananda Krolicka, Adriana Tran, Tam T. Räisänen, Kati Ásmundsdóttir, Ásta Margrét Wikmark, Odd Gunnar Lood, Rolf Pitkänen, Tarja Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
topic_facet |
Infectious Medicine Antibiotic resistance Carbapenemase-producing Enterobacterales Clinical surveillance Extended-spectrum beta-lactamase Nordic Vancomycin-resistant Enterococcus |
description |
The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have effectively kept lower antibiotic-resistant bacterial (ARB) pathogen rates than many other countries. However, in recent years, these five countries have encountered a rise in ARB cases and challenges in treating infections due to the growing prevalence of ARB pathogens. Wastewater-based surveillance (WBS) is a valuable supplement to clinical methods for ARB surveillance, but there is a lack of comprehensive understanding of WBS application for ARB in the Nordic countries. This review aims to compile the latest state-of-the-art developments in WBS for ARB monitoring in the Nordic countries and compare them with clinical surveillance practices. After reviewing 1480 papers from the primary search, 54 were found relevant, and 15 additional WBS-related papers were included. Among 69 studies analyzed, 42 dedicated clinical epidemiology, while 27 focused on wastewater monitoring. The PRISMA review of the literature revealed that Nordic countries focus on four major WBS objectives of ARB: assessing ARB in the human population, identifying ARB evading wastewater treatment, quantifying removal rates, and evaluating potential ARB evolution during the treatment process. In both clinical and wastewater contexts, the most studied targets were pathogens producing carbapenemase and extended-spectrum beta-lactamase (ESBL), primarily Escherichia coli and Klebsiella spp. However, vancomycin-resistant Enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) have received more attention in clinical epidemiology than in wastewater studies, probably due to their lower detection rates in wastewater. Clinical surveillance has mostly used culturing, antibiotic susceptibility testing, and genotyping, but WBS employed PCR-based and metagenomics alongside culture-based techniques. Imported cases resulting from international travel and hospitalization abroad appear to have frequently contributed to the rise in ARB pathogen cases in these countries. ... |
format |
Article in Journal/Newspaper |
author |
Tiwari, Ananda Krolicka, Adriana Tran, Tam T. Räisänen, Kati Ásmundsdóttir, Ásta Margrét Wikmark, Odd Gunnar Lood, Rolf Pitkänen, Tarja |
author_facet |
Tiwari, Ananda Krolicka, Adriana Tran, Tam T. Räisänen, Kati Ásmundsdóttir, Ásta Margrét Wikmark, Odd Gunnar Lood, Rolf Pitkänen, Tarja |
author_sort |
Tiwari, Ananda |
title |
Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
title_short |
Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
title_full |
Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
title_fullStr |
Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
title_full_unstemmed |
Antibiotic resistance monitoring in wastewater in the Nordic countries : A systematic review |
title_sort |
antibiotic resistance monitoring in wastewater in the nordic countries : a systematic review |
publisher |
Elsevier |
publishDate |
2024 |
url |
https://lup.lub.lu.se/record/8d86a9e4-d9d4-4f06-893b-1ab2d193dedb https://doi.org/10.1016/j.envres.2023.118052 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Environmental Research; 246, no 118052 (2024) ISSN: 0013-9351 |
op_relation |
https://lup.lub.lu.se/record/8d86a9e4-d9d4-4f06-893b-1ab2d193dedb http://dx.doi.org/10.1016/j.envres.2023.118052 scopus:85182021488 pmid:38163547 |
op_doi |
https://doi.org/10.1016/j.envres.2023.118052 |
container_title |
Environmental Research |
container_volume |
246 |
container_start_page |
118052 |
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1799482692272652288 |