Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations
BACKGROUND: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5...
Published in: | Environmental Health |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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BioMed Central (BMC)
2005
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Online Access: | https://lup.lub.lu.se/record/1132105 https://doi.org/10.1186/1476-069X-4-27 |
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ftulundlup:oai:lup.lub.lu.se:7fcc45c5-84ea-4fbe-9554-2649cb498e0c 2023-05-15T16:31:12+02:00 Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations Jönsson, Bo A Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Goralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars 2005 https://lup.lub.lu.se/record/1132105 https://doi.org/10.1186/1476-069X-4-27 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/1132105 http://dx.doi.org/10.1186/1476-069X-4-27 pmid:16283941 scopus:28844459043 Environmental Health; 4(27) (2005) ISSN: 1476-069X Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2005 ftulundlup https://doi.org/10.1186/1476-069X-4-27 2023-02-01T23:27:07Z BACKGROUND: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. METHOD: In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. RESULTS: The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. CONCLUSION: CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the ... Article in Journal/Newspaper greenlandic inuit inuits Lund University Publications (LUP) Environmental Health 4 1 |
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Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Jönsson, Bo A Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Goralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
topic_facet |
Environmental Health and Occupational Health |
description |
BACKGROUND: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. METHOD: In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. RESULTS: The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. CONCLUSION: CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the ... |
format |
Article in Journal/Newspaper |
author |
Jönsson, Bo A Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Goralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars |
author_facet |
Jönsson, Bo A Rylander, Lars Lindh, Christian Rignell-Hydbom, Anna Giwercman, Aleksander Toft, Gunnar Pedersen, Henning S Ludwicki, Jan K Goralczyk, Katarzyna Zvyezday, Valentyna Spanò, Marcello Bizzaro, Davide Bonefeld-Jörgensen, Eva C Manicardi, Gian Carlo Bonde, Jens Peter Hagmar, Lars |
author_sort |
Jönsson, Bo A |
title |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_short |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_full |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_fullStr |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_full_unstemmed |
Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations |
title_sort |
inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (cb-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-dde): a cross-sectional study of 3161 men and women from inuit and european populations |
publisher |
BioMed Central (BMC) |
publishDate |
2005 |
url |
https://lup.lub.lu.se/record/1132105 https://doi.org/10.1186/1476-069X-4-27 |
genre |
greenlandic inuit inuits |
genre_facet |
greenlandic inuit inuits |
op_source |
Environmental Health; 4(27) (2005) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/1132105 http://dx.doi.org/10.1186/1476-069X-4-27 pmid:16283941 scopus:28844459043 |
op_doi |
https://doi.org/10.1186/1476-069X-4-27 |
container_title |
Environmental Health |
container_volume |
4 |
container_issue |
1 |
_version_ |
1766020969970794496 |