Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.
Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in fiv...
Published in: | International Journal of Obesity |
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Language: | English |
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2014
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Online Access: | https://lup.lub.lu.se/record/4430494 https://doi.org/10.1038/ijo.2014.58 |
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ftulundlup:oai:lup.lub.lu.se:730d3525-3dc6-4aa9-8fc6-52f61283fa53 2023-05-15T16:29:57+02:00 Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. Høyer, B B Ramlau-Hansen, C H Henriksen, T B Pedersen, H S Góralczyk, K Zviezdai, V Jönsson, Bo A Heederik, D Lenters, V Vermeulen, R Peter Bonde, J Toft, G 2014 https://lup.lub.lu.se/record/4430494 https://doi.org/10.1038/ijo.2014.58 eng eng Nature Publishing Group https://lup.lub.lu.se/record/4430494 http://dx.doi.org/10.1038/ijo.2014.58 pmid:24718355 wos:000339197000004 scopus:84904042649 International Journal of Obesity; 38(7), pp 919-925 (2014) ISSN: 1476-5497 Nutrition and Dietetics contributiontojournal/article info:eu-repo/semantics/article text 2014 ftulundlup https://doi.org/10.1038/ijo.2014.58 2023-02-01T23:29:50Z Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58. Article in Journal/Newspaper Greenland greenlandic Lund University Publications (LUP) Greenland International Journal of Obesity 38 7 919 925 |
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Lund University Publications (LUP) |
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English |
topic |
Nutrition and Dietetics |
spellingShingle |
Nutrition and Dietetics Høyer, B B Ramlau-Hansen, C H Henriksen, T B Pedersen, H S Góralczyk, K Zviezdai, V Jönsson, Bo A Heederik, D Lenters, V Vermeulen, R Peter Bonde, J Toft, G Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
topic_facet |
Nutrition and Dietetics |
description |
Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58. |
format |
Article in Journal/Newspaper |
author |
Høyer, B B Ramlau-Hansen, C H Henriksen, T B Pedersen, H S Góralczyk, K Zviezdai, V Jönsson, Bo A Heederik, D Lenters, V Vermeulen, R Peter Bonde, J Toft, G |
author_facet |
Høyer, B B Ramlau-Hansen, C H Henriksen, T B Pedersen, H S Góralczyk, K Zviezdai, V Jönsson, Bo A Heederik, D Lenters, V Vermeulen, R Peter Bonde, J Toft, G |
author_sort |
Høyer, B B |
title |
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
title_short |
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
title_full |
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
title_fullStr |
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
title_full_unstemmed |
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
title_sort |
body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study. |
publisher |
Nature Publishing Group |
publishDate |
2014 |
url |
https://lup.lub.lu.se/record/4430494 https://doi.org/10.1038/ijo.2014.58 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_source |
International Journal of Obesity; 38(7), pp 919-925 (2014) ISSN: 1476-5497 |
op_relation |
https://lup.lub.lu.se/record/4430494 http://dx.doi.org/10.1038/ijo.2014.58 pmid:24718355 wos:000339197000004 scopus:84904042649 |
op_doi |
https://doi.org/10.1038/ijo.2014.58 |
container_title |
International Journal of Obesity |
container_volume |
38 |
container_issue |
7 |
container_start_page |
919 |
op_container_end_page |
925 |
_version_ |
1766019656703803392 |