Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples
Several studies have investigated the relation between bone mass density and cadmium exposure, but only few studies have been performed on fractures and biomarkers of cadmium. This study analyzed the association between hip fracture risk and cadmium in erythrocytes (Ery-Cd). Prospective samples from...
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ftulundlup:oai:lup.lub.lu.se:6a7b9f16-33b4-4274-866a-daaadddde8b4 2023-05-15T17:45:00+02:00 Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples Sommar, Johan Nilsson Pettersson-Kymmer, Ulrika Lundh, Thomas Svensson, Olle Hallmans, Goran Bergdahl, Ingvar A. 2014 https://lup.lub.lu.se/record/4376365 https://doi.org/10.1007/s00223-013-9796-5 eng eng Springer https://lup.lub.lu.se/record/4376365 http://dx.doi.org/10.1007/s00223-013-9796-5 wos:000330827700007 scopus:84893234806 Calcified Tissue International; 94(2), pp 183-190 (2014) ISSN: 1432-0827 Environmental Health and Occupational Health Cadmium Environmental exposure Heavy metal Hip fracture Prospective contributiontojournal/article info:eu-repo/semantics/article text 2014 ftulundlup https://doi.org/10.1007/s00223-013-9796-5 2023-02-01T23:32:41Z Several studies have investigated the relation between bone mass density and cadmium exposure, but only few studies have been performed on fractures and biomarkers of cadmium. This study analyzed the association between hip fracture risk and cadmium in erythrocytes (Ery-Cd). Prospective samples from the Northern Sweden Health and Disease Study's biobank were used for 109 individuals who later in life had sustained a low-trauma hip fracture, matched with two controls of the same age and gender. The mean concentration of Ery-Cd (+/- SD) in case samples was 1.3 +/- A 1.4 versus 0.9 +/- A 1.0 mu g/L in controls. The odds ratio (OR) was 1.63 [95 % confidence interval (CI) 1.10-2.42] for suffering a hip fracture for each microgram per liter increase in Ery-Cd. However, when taking smoking into consideration (never, former, or current), neither Ery-Cd nor smoking showed a statistically significant increase in fracture risk. Using multiple conditional logistic regression with BMI, height, and smoking, the estimated OR for a 1-mu g/L increase in Ery-Cd was 1.52 (95 % CI 0.77-2.97). Subgroup analysis showed an increased fracture risk among women (OR = 1.94, 95 % CI 1.18-3.20, for a 1 mu g/L increase), which also remained in the multiple analysis (OR = 3.33, 95 % CI 1.29-8.56). This study shows that fracture risk is associated with Ery-Cd. It is, however, not possible to draw firm conclusions on whether cadmium is the causal factor or whether other smoking-related factors cause this association. Subgroup analysis shows that cadmium is a risk factor for hip fracture among women. Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Calcified Tissue International 94 2 183 190 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Cadmium Environmental exposure Heavy metal Hip fracture Prospective |
spellingShingle |
Environmental Health and Occupational Health Cadmium Environmental exposure Heavy metal Hip fracture Prospective Sommar, Johan Nilsson Pettersson-Kymmer, Ulrika Lundh, Thomas Svensson, Olle Hallmans, Goran Bergdahl, Ingvar A. Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
topic_facet |
Environmental Health and Occupational Health Cadmium Environmental exposure Heavy metal Hip fracture Prospective |
description |
Several studies have investigated the relation between bone mass density and cadmium exposure, but only few studies have been performed on fractures and biomarkers of cadmium. This study analyzed the association between hip fracture risk and cadmium in erythrocytes (Ery-Cd). Prospective samples from the Northern Sweden Health and Disease Study's biobank were used for 109 individuals who later in life had sustained a low-trauma hip fracture, matched with two controls of the same age and gender. The mean concentration of Ery-Cd (+/- SD) in case samples was 1.3 +/- A 1.4 versus 0.9 +/- A 1.0 mu g/L in controls. The odds ratio (OR) was 1.63 [95 % confidence interval (CI) 1.10-2.42] for suffering a hip fracture for each microgram per liter increase in Ery-Cd. However, when taking smoking into consideration (never, former, or current), neither Ery-Cd nor smoking showed a statistically significant increase in fracture risk. Using multiple conditional logistic regression with BMI, height, and smoking, the estimated OR for a 1-mu g/L increase in Ery-Cd was 1.52 (95 % CI 0.77-2.97). Subgroup analysis showed an increased fracture risk among women (OR = 1.94, 95 % CI 1.18-3.20, for a 1 mu g/L increase), which also remained in the multiple analysis (OR = 3.33, 95 % CI 1.29-8.56). This study shows that fracture risk is associated with Ery-Cd. It is, however, not possible to draw firm conclusions on whether cadmium is the causal factor or whether other smoking-related factors cause this association. Subgroup analysis shows that cadmium is a risk factor for hip fracture among women. |
format |
Article in Journal/Newspaper |
author |
Sommar, Johan Nilsson Pettersson-Kymmer, Ulrika Lundh, Thomas Svensson, Olle Hallmans, Goran Bergdahl, Ingvar A. |
author_facet |
Sommar, Johan Nilsson Pettersson-Kymmer, Ulrika Lundh, Thomas Svensson, Olle Hallmans, Goran Bergdahl, Ingvar A. |
author_sort |
Sommar, Johan Nilsson |
title |
Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
title_short |
Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
title_full |
Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
title_fullStr |
Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
title_full_unstemmed |
Hip Fracture Risk and Cadmium in Erythrocytes: A Nested Case-Control Study with Prospectively Collected Samples |
title_sort |
hip fracture risk and cadmium in erythrocytes: a nested case-control study with prospectively collected samples |
publisher |
Springer |
publishDate |
2014 |
url |
https://lup.lub.lu.se/record/4376365 https://doi.org/10.1007/s00223-013-9796-5 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Calcified Tissue International; 94(2), pp 183-190 (2014) ISSN: 1432-0827 |
op_relation |
https://lup.lub.lu.se/record/4376365 http://dx.doi.org/10.1007/s00223-013-9796-5 wos:000330827700007 scopus:84893234806 |
op_doi |
https://doi.org/10.1007/s00223-013-9796-5 |
container_title |
Calcified Tissue International |
container_volume |
94 |
container_issue |
2 |
container_start_page |
183 |
op_container_end_page |
190 |
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1766147710987010048 |