Somatic disease in survivors of childhood malignant bone tumors in the nordic countries
Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteo...
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MDPI AG
2021
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Online Access: | https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823b https://doi.org/10.3390/cancers13184505 |
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ftulundlup:oai:lup.lub.lu.se:5e300689-7165-4ced-a21d-61989db7823b 2024-04-28T08:26:05+00:00 Somatic disease in survivors of childhood malignant bone tumors in the nordic countries Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck 2021 https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823b https://doi.org/10.3390/cancers13184505 eng eng MDPI AG https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823b http://dx.doi.org/10.3390/cancers13184505 scopus:85114315951 pmid:34572734 Cancers; 13(18), no 4505 (2021) ISSN: 2072-6694 Cancer and Oncology Childhood malignant bone tumors Cohort study Late effects Somatic disease Survivorship contributiontojournal/article info:eu-repo/semantics/article text 2021 ftulundlup https://doi.org/10.3390/cancers13184505 2024-04-09T23:48:56Z Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval (CI) 1.76–2.85) than after osteosarcoma (RR 1.67; 95% CI 1.41–1.98). Elevated rates were observed for 11 main diagnostic groups, including infections, second malignant neoplasms, and diseases of the skin, bones, and circulatory, digestive, endocrine, and urinary systems. Survivors of malignant bone tumors in childhood are at increased risk of somatic diseases many years after diagnosis. This comprehensive study contributes new insight into the risk of late effects in survivors of osteosarcoma and Ewing sarcoma, which is an essential basis for optimal patient counseling and follow-up care. Article in Journal/Newspaper Iceland Lund University Publications (LUP) Cancers 13 18 4505 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology Childhood malignant bone tumors Cohort study Late effects Somatic disease Survivorship |
spellingShingle |
Cancer and Oncology Childhood malignant bone tumors Cohort study Late effects Somatic disease Survivorship Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
topic_facet |
Cancer and Oncology Childhood malignant bone tumors Cohort study Late effects Somatic disease Survivorship |
description |
Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval (CI) 1.76–2.85) than after osteosarcoma (RR 1.67; 95% CI 1.41–1.98). Elevated rates were observed for 11 main diagnostic groups, including infections, second malignant neoplasms, and diseases of the skin, bones, and circulatory, digestive, endocrine, and urinary systems. Survivors of malignant bone tumors in childhood are at increased risk of somatic diseases many years after diagnosis. This comprehensive study contributes new insight into the risk of late effects in survivors of osteosarcoma and Ewing sarcoma, which is an essential basis for optimal patient counseling and follow-up care. |
format |
Article in Journal/Newspaper |
author |
Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck |
author_facet |
Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck |
author_sort |
Pedersen, Camilla |
title |
Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
title_short |
Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
title_full |
Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
title_fullStr |
Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
title_full_unstemmed |
Somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
title_sort |
somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823b https://doi.org/10.3390/cancers13184505 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancers; 13(18), no 4505 (2021) ISSN: 2072-6694 |
op_relation |
https://lup.lub.lu.se/record/5e300689-7165-4ced-a21d-61989db7823b http://dx.doi.org/10.3390/cancers13184505 scopus:85114315951 pmid:34572734 |
op_doi |
https://doi.org/10.3390/cancers13184505 |
container_title |
Cancers |
container_volume |
13 |
container_issue |
18 |
container_start_page |
4505 |
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1797585623614226432 |