Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland
Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Gre...
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ftulundlup:oai:lup.lub.lu.se:5df68966-042a-4899-b49e-263c867d2eea 2023-05-15T16:28:21+02:00 Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Pedersen, Henning Sloth Goralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo A Bonde, Jens Peter Toft, Gunnar 2015 application/pdf https://lup.lub.lu.se/record/5160154 https://doi.org/10.1186/s12889-015-1465-3 https://portal.research.lu.se/files/8182079/8227612 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/5160154 http://dx.doi.org/10.1186/s12889-015-1465-3 https://portal.research.lu.se/files/8182079/8227612 wos:000349751800001 scopus:84924259349 pmid:25885170 info:eu-repo/semantics/openAccess BMC Public Health; 15(146), pp 1-11 (2015) ISSN: 1471-2458 Public Health Global Health Social Medicine and Epidemiology Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure contributiontojournal/article info:eu-repo/semantics/article text 2015 ftulundlup https://doi.org/10.1186/s12889-015-1465-3 2023-02-01T23:26:50Z Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland BMC Public Health 15 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Pedersen, Henning Sloth Goralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo A Bonde, Jens Peter Toft, Gunnar Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure |
description |
Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified. |
format |
Article in Journal/Newspaper |
author |
Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Pedersen, Henning Sloth Goralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo A Bonde, Jens Peter Toft, Gunnar |
author_facet |
Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Pedersen, Henning Sloth Goralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo A Bonde, Jens Peter Toft, Gunnar |
author_sort |
Hoyer, Birgit Bjerre |
title |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
title_short |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
title_full |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
title_fullStr |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
title_full_unstemmed |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland |
title_sort |
motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in greenland, ukraine and poland |
publisher |
BioMed Central (BMC) |
publishDate |
2015 |
url |
https://lup.lub.lu.se/record/5160154 https://doi.org/10.1186/s12889-015-1465-3 https://portal.research.lu.se/files/8182079/8227612 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
BMC Public Health; 15(146), pp 1-11 (2015) ISSN: 1471-2458 |
op_relation |
https://lup.lub.lu.se/record/5160154 http://dx.doi.org/10.1186/s12889-015-1465-3 https://portal.research.lu.se/files/8182079/8227612 wos:000349751800001 scopus:84924259349 pmid:25885170 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12889-015-1465-3 |
container_title |
BMC Public Health |
container_volume |
15 |
container_issue |
1 |
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1766017988529487872 |