Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam
BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along wit...
Published in: | Environmental Health Perspectives |
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National Institute of Environmental Health Sciences
2020
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Online Access: | https://lup.lub.lu.se/record/5c956ed1-99cc-4fc0-b313-19feb362bf0c https://doi.org/10.1289/EHP6785 |
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ftulundlup:oai:lup.lub.lu.se:5c956ed1-99cc-4fc0-b313-19feb362bf0c 2024-05-19T07:46:11+00:00 Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam Xu, Yiyi Fletcher, Tony Pineda, Daniela Lindh, Christian H Nilsson, Carina Glynn, Anders Vogs, Carolina Norström, Karin Lilja, Karl Jakobsson, Kristina Li, Ying 2020-07 https://lup.lub.lu.se/record/5c956ed1-99cc-4fc0-b313-19feb362bf0c https://doi.org/10.1289/EHP6785 eng eng National Institute of Environmental Health Sciences https://lup.lub.lu.se/record/5c956ed1-99cc-4fc0-b313-19feb362bf0c http://dx.doi.org/10.1289/EHP6785 pmid:32648786 scopus:85088200914 Environmental Health Perspectives; 128(7), pp 77004-77004 (2020) ISSN: 1552-9924 Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2020 ftulundlup https://doi.org/10.1289/EHP6785 2024-04-23T23:40:16Z BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water.OBJECTIVES: In this study, we aimed to describe the PFAS profile in drinking water and biological samples (paired serum and urine) and to estimate serum half-lives of the short-chain PFAS together with legacy PFAS.METHODS: Within 2 weeks after provision of clean water, blood sampling was performed in all 26 airport employees. Seventeen of them were then followed up monthly for 5 months. PFHxA, PFHpA, PFBS, PFPeS, and PFHpS together with legacy PFAS in water and biological samples were quantified using LC/MS/MS. Half-lives were estimated by assuming one compartment, first-order elimination kinetics.RESULTS: The proportions of PFHxA, PFHpA, and PFBS were higher in drinking water than in serum. The opposite was found for PFHxS and PFOS. The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in serum. Urinary PFAS levels were very low compared with serum. PFBS showed the shortest half-life {average 44 d [95% confidence interval (CI): 37, 55 d]}, followed by PFHpA [62 d (95% CI: 51, 80 d)]. PFPeS and PFHpS showed average half-lives as 0.63 and 1.46 y, respectively. Branched PFOS isomers had average half-lives ranging from 1.05 to 1.26 y for different isomers. PFOA, PFHxS, and linear PFOS isomers showed average half-lives of 1.77, 2.87, and 2.93 y, respectively.DISCUSSION: A general pattern of increasing half-lives with increasing chain length was observed. Branched PFOS isomers had shorter half-lives than linear PFOS isomers. https://doi.org/10.1289/EHP6785. Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Environmental Health Perspectives 128 7 077004 |
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Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Xu, Yiyi Fletcher, Tony Pineda, Daniela Lindh, Christian H Nilsson, Carina Glynn, Anders Vogs, Carolina Norström, Karin Lilja, Karl Jakobsson, Kristina Li, Ying Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
topic_facet |
Environmental Health and Occupational Health |
description |
BACKGROUND: Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water.OBJECTIVES: In this study, we aimed to describe the PFAS profile in drinking water and biological samples (paired serum and urine) and to estimate serum half-lives of the short-chain PFAS together with legacy PFAS.METHODS: Within 2 weeks after provision of clean water, blood sampling was performed in all 26 airport employees. Seventeen of them were then followed up monthly for 5 months. PFHxA, PFHpA, PFBS, PFPeS, and PFHpS together with legacy PFAS in water and biological samples were quantified using LC/MS/MS. Half-lives were estimated by assuming one compartment, first-order elimination kinetics.RESULTS: The proportions of PFHxA, PFHpA, and PFBS were higher in drinking water than in serum. The opposite was found for PFHxS and PFOS. The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in serum. Urinary PFAS levels were very low compared with serum. PFBS showed the shortest half-life {average 44 d [95% confidence interval (CI): 37, 55 d]}, followed by PFHpA [62 d (95% CI: 51, 80 d)]. PFPeS and PFHpS showed average half-lives as 0.63 and 1.46 y, respectively. Branched PFOS isomers had average half-lives ranging from 1.05 to 1.26 y for different isomers. PFOA, PFHxS, and linear PFOS isomers showed average half-lives of 1.77, 2.87, and 2.93 y, respectively.DISCUSSION: A general pattern of increasing half-lives with increasing chain length was observed. Branched PFOS isomers had shorter half-lives than linear PFOS isomers. https://doi.org/10.1289/EHP6785. |
format |
Article in Journal/Newspaper |
author |
Xu, Yiyi Fletcher, Tony Pineda, Daniela Lindh, Christian H Nilsson, Carina Glynn, Anders Vogs, Carolina Norström, Karin Lilja, Karl Jakobsson, Kristina Li, Ying |
author_facet |
Xu, Yiyi Fletcher, Tony Pineda, Daniela Lindh, Christian H Nilsson, Carina Glynn, Anders Vogs, Carolina Norström, Karin Lilja, Karl Jakobsson, Kristina Li, Ying |
author_sort |
Xu, Yiyi |
title |
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
title_short |
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
title_full |
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
title_fullStr |
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
title_full_unstemmed |
Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam |
title_sort |
serum half-lives for short- and long-chain perfluoroalkyl acids after ceasing exposure from drinking water contaminated by firefighting foam |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2020 |
url |
https://lup.lub.lu.se/record/5c956ed1-99cc-4fc0-b313-19feb362bf0c https://doi.org/10.1289/EHP6785 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Environmental Health Perspectives; 128(7), pp 77004-77004 (2020) ISSN: 1552-9924 |
op_relation |
https://lup.lub.lu.se/record/5c956ed1-99cc-4fc0-b313-19feb362bf0c http://dx.doi.org/10.1289/EHP6785 pmid:32648786 scopus:85088200914 |
op_doi |
https://doi.org/10.1289/EHP6785 |
container_title |
Environmental Health Perspectives |
container_volume |
128 |
container_issue |
7 |
container_start_page |
077004 |
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1799486315167744000 |