Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromso study

The aim of this study was to examine whether CAG/GGN repeats are significant modulators of serum concentrations of total and free testosterone (T) as well as of luteinizing hormone (LH) in elderly men. Sixty-nine 60- to 80-year-old men with subnormal T levels (<= 11.0 nmol L-1) and 104 men with n...

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Bibliographic Details
Published in:Asian Journal of Andrology
Main Authors: Skjaerpe, Paal Andre, Giwercman, Yvonne, Giwercman, Aleksander, Svartberg, Johan
Format: Article in Journal/Newspaper
Language:English
Published: Nature Publishing Group 2009
Subjects:
Obstetrics
Gynecology and Reproductive Medicine
androgen receptor gene polymorphism
testosterone
luteinizing hormone
Tromso
Online Access:https://lup.lub.lu.se/record/1371988
https://doi.org/10.1038/aja.2008.7
Description
Summary:The aim of this study was to examine whether CAG/GGN repeats are significant modulators of serum concentrations of total and free testosterone (T) as well as of luteinizing hormone (LH) in elderly men. Sixty-nine 60- to 80-year-old men with subnormal T levels (<= 11.0 nmol L-1) and 104 men with normal T levels taking part in a nested case-control study were used for these analyses. Sex hormones were measured and free T was calculated. The CAG and GGN polymorphisms in the androgen receptor gene were determined by polymerase chain reaction and subsequent direct sequencing. There were no differences in the CAG and GGN repeat lengths between the groups. In cross-sectional analyses of the whole cohort, total and free T were positively associated with CAG length (all P < 0.05) before, but not after, waist circumference or body mass index was added to the model. CAG repeat lengths were weakly, but not independently, associated with total and free T. These findings indicate that when clinically evaluating T and LH levels in elderly men, the CAG and GGN repeat lengths do not need to be taken into consideration.

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