Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines
OBJECTIVE: We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18...
Published in: | Environmental Health Perspectives |
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Language: | English |
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National Institute of Environmental Health Sciences
2008
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Online Access: | https://lup.lub.lu.se/record/1193593 https://doi.org/10.1289/ehp.10700 |
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ftulundlup:oai:lup.lub.lu.se:559b2293-5f93-4346-93a0-b77182e31fca 2023-05-15T16:31:12+02:00 Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines Bonde, Jens Peter Toftl, Gunnar Rylander, Lars Rignell-Hydbom, Anna Giwercman, Aleksander Spano, Marcelli Manicardi, Gian Carlo Bizzaro, Davide Ludwicki, Jan K. Zvyezday, Valentina Bonefeld-Jorgensen, Eva C. Pedersen, Henning Sloth Joensson, Bo A. G. Thulstrup, Ane Marie 2008 https://lup.lub.lu.se/record/1193593 https://doi.org/10.1289/ehp.10700 eng eng National Institute of Environmental Health Sciences https://lup.lub.lu.se/record/1193593 http://dx.doi.org/10.1289/ehp.10700 wos:000253670600020 scopus:40849137786 Environmental Health Perspectives; 116(3), pp 269-277 (2008) ISSN: 1552-9924 Environmental Health and Occupational Health xenobiotics time to pregnancy receptors sex hormone semen quality reproductive health inuit polymorphisms contributiontojournal/systematicreview info:eu-repo/semantics/article text 2008 ftulundlup https://doi.org/10.1289/ehp.10700 2023-02-01T23:35:43Z OBJECTIVE: We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. DATA SYNTHESIS: The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1 1 1 -dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral alpha-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified. CONCLUSIONS: POPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered. Article in Journal/Newspaper greenlandic inuit inuits Lund University Publications (LUP) Environmental Health Perspectives 116 3 269 277 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health xenobiotics time to pregnancy receptors sex hormone semen quality reproductive health inuit polymorphisms |
spellingShingle |
Environmental Health and Occupational Health xenobiotics time to pregnancy receptors sex hormone semen quality reproductive health inuit polymorphisms Bonde, Jens Peter Toftl, Gunnar Rylander, Lars Rignell-Hydbom, Anna Giwercman, Aleksander Spano, Marcelli Manicardi, Gian Carlo Bizzaro, Davide Ludwicki, Jan K. Zvyezday, Valentina Bonefeld-Jorgensen, Eva C. Pedersen, Henning Sloth Joensson, Bo A. G. Thulstrup, Ane Marie Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
topic_facet |
Environmental Health and Occupational Health xenobiotics time to pregnancy receptors sex hormone semen quality reproductive health inuit polymorphisms |
description |
OBJECTIVE: We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. DATA SYNTHESIS: The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1 1 1 -dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral alpha-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified. CONCLUSIONS: POPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered. |
format |
Article in Journal/Newspaper |
author |
Bonde, Jens Peter Toftl, Gunnar Rylander, Lars Rignell-Hydbom, Anna Giwercman, Aleksander Spano, Marcelli Manicardi, Gian Carlo Bizzaro, Davide Ludwicki, Jan K. Zvyezday, Valentina Bonefeld-Jorgensen, Eva C. Pedersen, Henning Sloth Joensson, Bo A. G. Thulstrup, Ane Marie |
author_facet |
Bonde, Jens Peter Toftl, Gunnar Rylander, Lars Rignell-Hydbom, Anna Giwercman, Aleksander Spano, Marcelli Manicardi, Gian Carlo Bizzaro, Davide Ludwicki, Jan K. Zvyezday, Valentina Bonefeld-Jorgensen, Eva C. Pedersen, Henning Sloth Joensson, Bo A. G. Thulstrup, Ane Marie |
author_sort |
Bonde, Jens Peter |
title |
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
title_short |
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
title_full |
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
title_fullStr |
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
title_full_unstemmed |
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines |
title_sort |
fertility and markers of male reproductive function in inuit and european populations spanning large contrasts in blood levels of persistent organochlorines |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2008 |
url |
https://lup.lub.lu.se/record/1193593 https://doi.org/10.1289/ehp.10700 |
genre |
greenlandic inuit inuits |
genre_facet |
greenlandic inuit inuits |
op_source |
Environmental Health Perspectives; 116(3), pp 269-277 (2008) ISSN: 1552-9924 |
op_relation |
https://lup.lub.lu.se/record/1193593 http://dx.doi.org/10.1289/ehp.10700 wos:000253670600020 scopus:40849137786 |
op_doi |
https://doi.org/10.1289/ehp.10700 |
container_title |
Environmental Health Perspectives |
container_volume |
116 |
container_issue |
3 |
container_start_page |
269 |
op_container_end_page |
277 |
_version_ |
1766020965296242688 |