Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries.
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic c...
Published in: | International Journal of Cancer |
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John Wiley & Sons Inc.
2012
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Online Access: | https://lup.lub.lu.se/record/2274029 https://doi.org/10.1002/ijc.27393 |
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ftulundlup:oai:lup.lub.lu.se:49e8a4b9-b334-4733-8a22-c1017a69fb3e 2023-05-15T16:51:38+02:00 Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. Garwicz, Stanislaw Anderson, Harald Olsen, Jørgen H Falck Winther, Jeanette Sankila, Risto Langmark, Frøydis Tryggvadóttir, Laufey Möller, Torgil 2012 https://lup.lub.lu.se/record/2274029 https://doi.org/10.1002/ijc.27393 eng eng John Wiley & Sons Inc. https://lup.lub.lu.se/record/2274029 http://dx.doi.org/10.1002/ijc.27393 wos:000306915700033 pmid:22170520 scopus:84864432282 International Journal of Cancer; 131(7), pp 1659-1666 (2012) ISSN: 0020-7136 Cancer and Oncology late mortality childhood cancer very late mortality 5-year survivors long-term follow-up contributiontojournal/article info:eu-repo/semantics/article text 2012 ftulundlup https://doi.org/10.1002/ijc.27393 2023-02-01T23:29:14Z Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed-up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and non-cancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-99, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality. Article in Journal/Newspaper Iceland Lund University Publications (LUP) Norway International Journal of Cancer 131 7 1659 1666 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology late mortality childhood cancer very late mortality 5-year survivors long-term follow-up |
spellingShingle |
Cancer and Oncology late mortality childhood cancer very late mortality 5-year survivors long-term follow-up Garwicz, Stanislaw Anderson, Harald Olsen, Jørgen H Falck Winther, Jeanette Sankila, Risto Langmark, Frøydis Tryggvadóttir, Laufey Möller, Torgil Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
topic_facet |
Cancer and Oncology late mortality childhood cancer very late mortality 5-year survivors long-term follow-up |
description |
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in five year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed-up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and non-cancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-99, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality. |
format |
Article in Journal/Newspaper |
author |
Garwicz, Stanislaw Anderson, Harald Olsen, Jørgen H Falck Winther, Jeanette Sankila, Risto Langmark, Frøydis Tryggvadóttir, Laufey Möller, Torgil |
author_facet |
Garwicz, Stanislaw Anderson, Harald Olsen, Jørgen H Falck Winther, Jeanette Sankila, Risto Langmark, Frøydis Tryggvadóttir, Laufey Möller, Torgil |
author_sort |
Garwicz, Stanislaw |
title |
Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
title_short |
Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
title_full |
Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
title_fullStr |
Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
title_full_unstemmed |
Late and very late mortality in 5-year survivors of childhood cancer: Changing pattern over four decades. Experience from the Nordic countries. |
title_sort |
late and very late mortality in 5-year survivors of childhood cancer: changing pattern over four decades. experience from the nordic countries. |
publisher |
John Wiley & Sons Inc. |
publishDate |
2012 |
url |
https://lup.lub.lu.se/record/2274029 https://doi.org/10.1002/ijc.27393 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer; 131(7), pp 1659-1666 (2012) ISSN: 0020-7136 |
op_relation |
https://lup.lub.lu.se/record/2274029 http://dx.doi.org/10.1002/ijc.27393 wos:000306915700033 pmid:22170520 scopus:84864432282 |
op_doi |
https://doi.org/10.1002/ijc.27393 |
container_title |
International Journal of Cancer |
container_volume |
131 |
container_issue |
7 |
container_start_page |
1659 |
op_container_end_page |
1666 |
_version_ |
1766041763835805696 |