Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden
Diabetes mellitus (DM) incidence have been assessed in connection with air pollution exposure in several studies; however, few have investigated associations with source-specific local emissions. This study aims to estimate the risk of DM incidence associated with source-specific air pollution in a...
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2023
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Online Access: | https://lup.lub.lu.se/record/48c4ba53-a212-480b-9164-750885555352 https://doi.org/10.1016/j.envres.2022.114833 |
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ftulundlup:oai:lup.lub.lu.se:48c4ba53-a212-480b-9164-750885555352 2024-05-12T08:08:58+00:00 Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden Sommar, Johan N. Segersson, David Flanagan, Erin Oudin, Anna 2023-01-15 https://lup.lub.lu.se/record/48c4ba53-a212-480b-9164-750885555352 https://doi.org/10.1016/j.envres.2022.114833 eng eng Elsevier https://lup.lub.lu.se/record/48c4ba53-a212-480b-9164-750885555352 http://dx.doi.org/10.1016/j.envres.2022.114833 pmid:36402182 scopus:85145580527 Environmental Research; 217, no 114833 (2023) ISSN: 0013-9351 Environmental Health and Occupational Health Air pollution Cohort Diabetes mellitus Exhaust Particulate matter Traffic emissions contributiontojournal/article info:eu-repo/semantics/article text 2023 ftulundlup https://doi.org/10.1016/j.envres.2022.114833 2024-04-17T14:16:17Z Diabetes mellitus (DM) incidence have been assessed in connection with air pollution exposure in several studies; however, few have investigated associations with source-specific local emissions. This study aims to estimate the risk of DM incidence associated with source-specific air pollution in a Swedish cohort with relatively low exposure. Individuals in the Västerbotten intervention programme cohort were followed until either a DM diagnosis or initiation of treatment with glucose-lowering medication occurred. Dispersion models with high spatial resolution were used to estimate annual mean concentrations of particulate matter (PM) with aerodynamic diameter ≤10 μm (PM10) and ≤2.5 μm (PM2.5) at individual addresses. Hazard ratios were estimated using Cox regression models in relation to moving averages 1–5 years preceding the outcome. During the study period, 1479 incident cases of DM were observed during 261,703 person-years of follow-up. Increased incidence of DM was observed in association with PM10 (4% [95% CI: -54–137%] per 10 μg/m3), PM10-traffic (2% [95% CI: -6–11%] per 1 μg/m3) and PM2.5-exhaust (11% [95% CI: -39–103%] per 1 μg/m3). A negative association was found for both PM2.5 (-18% [95% CI: -99–66%] per 5 μg/m3), but only in the 2nd exposure tertile (-10% [95% CI: -25–9%] compared to the first tertile), and PM2.5-woodburning (-30% [95% CI: -49–4%] per 1 μg/m3). In two-pollutant models including PM2.5-woodburning, there was an 11% [95% CI: -11–38%], 6% [95% CI: -16–34%], 13% [95% CI: -7–36%] and 17% [95% CI: 4–41%] higher risk in the 3rd tertile of PM10, PM2.5, PM10-traffic and PM2.5-exhaust, respectively, compared to the 1st. Although the results lacked in precision they are generally in line with the current evidence detailing particulate matter air pollution from traffic as an environmental risk factor for DM. Article in Journal/Newspaper Northern Sweden Lund University Publications (LUP) Environmental Research 217 114833 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Air pollution Cohort Diabetes mellitus Exhaust Particulate matter Traffic emissions |
spellingShingle |
Environmental Health and Occupational Health Air pollution Cohort Diabetes mellitus Exhaust Particulate matter Traffic emissions Sommar, Johan N. Segersson, David Flanagan, Erin Oudin, Anna Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
topic_facet |
Environmental Health and Occupational Health Air pollution Cohort Diabetes mellitus Exhaust Particulate matter Traffic emissions |
description |
Diabetes mellitus (DM) incidence have been assessed in connection with air pollution exposure in several studies; however, few have investigated associations with source-specific local emissions. This study aims to estimate the risk of DM incidence associated with source-specific air pollution in a Swedish cohort with relatively low exposure. Individuals in the Västerbotten intervention programme cohort were followed until either a DM diagnosis or initiation of treatment with glucose-lowering medication occurred. Dispersion models with high spatial resolution were used to estimate annual mean concentrations of particulate matter (PM) with aerodynamic diameter ≤10 μm (PM10) and ≤2.5 μm (PM2.5) at individual addresses. Hazard ratios were estimated using Cox regression models in relation to moving averages 1–5 years preceding the outcome. During the study period, 1479 incident cases of DM were observed during 261,703 person-years of follow-up. Increased incidence of DM was observed in association with PM10 (4% [95% CI: -54–137%] per 10 μg/m3), PM10-traffic (2% [95% CI: -6–11%] per 1 μg/m3) and PM2.5-exhaust (11% [95% CI: -39–103%] per 1 μg/m3). A negative association was found for both PM2.5 (-18% [95% CI: -99–66%] per 5 μg/m3), but only in the 2nd exposure tertile (-10% [95% CI: -25–9%] compared to the first tertile), and PM2.5-woodburning (-30% [95% CI: -49–4%] per 1 μg/m3). In two-pollutant models including PM2.5-woodburning, there was an 11% [95% CI: -11–38%], 6% [95% CI: -16–34%], 13% [95% CI: -7–36%] and 17% [95% CI: 4–41%] higher risk in the 3rd tertile of PM10, PM2.5, PM10-traffic and PM2.5-exhaust, respectively, compared to the 1st. Although the results lacked in precision they are generally in line with the current evidence detailing particulate matter air pollution from traffic as an environmental risk factor for DM. |
format |
Article in Journal/Newspaper |
author |
Sommar, Johan N. Segersson, David Flanagan, Erin Oudin, Anna |
author_facet |
Sommar, Johan N. Segersson, David Flanagan, Erin Oudin, Anna |
author_sort |
Sommar, Johan N. |
title |
Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
title_short |
Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
title_full |
Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
title_fullStr |
Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
title_full_unstemmed |
Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — A cohort study in northern Sweden |
title_sort |
long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus — a cohort study in northern sweden |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://lup.lub.lu.se/record/48c4ba53-a212-480b-9164-750885555352 https://doi.org/10.1016/j.envres.2022.114833 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Environmental Research; 217, no 114833 (2023) ISSN: 0013-9351 |
op_relation |
https://lup.lub.lu.se/record/48c4ba53-a212-480b-9164-750885555352 http://dx.doi.org/10.1016/j.envres.2022.114833 pmid:36402182 scopus:85145580527 |
op_doi |
https://doi.org/10.1016/j.envres.2022.114833 |
container_title |
Environmental Research |
container_volume |
217 |
container_start_page |
114833 |
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1798852112153575424 |