Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine.
Phthalates are ubiquitous industrial chemicals that have been associated with altered reproductive function in rodents. Several human studies have reported an inverse association between male testosterone and phthalate levels. Our aim was to investigate time to pregnancy (TTP) according to serum lev...
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ftulundlup:oai:lup.lub.lu.se:3c7bada8-2ea9-42d7-9837-cb0c1b65421f 2023-05-15T16:27:09+02:00 Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. Specht, Ina Olmer Bonde, Jens Peter Toft, Gunnar Lindh, Christian Jönsson, Bo A Jørgensen, Kristian T 2015 application/pdf https://lup.lub.lu.se/record/5258193 https://doi.org/10.1371/journal.pone.0120070 https://portal.research.lu.se/files/3708534/8255499 eng eng Public Library of Science (PLoS) https://lup.lub.lu.se/record/5258193 http://dx.doi.org/10.1371/journal.pone.0120070 https://portal.research.lu.se/files/3708534/8255499 pmid:25786246 wos:000352138500153 scopus:84925438707 info:eu-repo/semantics/openAccess PLoS ONE; 10(3), no e0120070 (2015) ISSN: 1932-6203 Environmental Health and Occupational Health contributiontojournal/article info:eu-repo/semantics/article text 2015 ftulundlup https://doi.org/10.1371/journal.pone.0120070 2023-02-01T23:35:27Z Phthalates are ubiquitous industrial chemicals that have been associated with altered reproductive function in rodents. Several human studies have reported an inverse association between male testosterone and phthalate levels. Our aim was to investigate time to pregnancy (TTP) according to serum levels of diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) metabolites in both partners. In 2002-2004 we enrolled 938 pregnant women and 401 male spouses from Greenland, Poland and Ukraine. Six oxidized metabolites of DEHP and DiNP were summarized for each of the two parent compounds to provide proxies of the internal exposure. We used Cox discrete-time models to estimate fecundability ratios (FR) and 95% confidence intervals (95% CIs) for men and women according to their proxy-DEHP or -DiNP serum levels adjusted for a fixed set of covariates. The FR was slightly elevated among women with high levels of DEHP (FR=1.14, 95% CI 1.00;1.30) suggesting a shorter TTP in these women. The FR was unrelated to DiNP in women, whereas the results for men were inconsistent pointing in opposite directions. First-time pregnant women from Greenland with high serum DiNP levels had a longer TTP. This study spanning large contrast in environmental exposure does not indicate adverse effects of phthalates on couple fecundity. The shorter TTP in women with high levels of DEHP metabolites is unexplained and needs further investigation. Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland PLOS ONE 10 3 e0120070 |
institution |
Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health |
spellingShingle |
Environmental Health and Occupational Health Specht, Ina Olmer Bonde, Jens Peter Toft, Gunnar Lindh, Christian Jönsson, Bo A Jørgensen, Kristian T Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
topic_facet |
Environmental Health and Occupational Health |
description |
Phthalates are ubiquitous industrial chemicals that have been associated with altered reproductive function in rodents. Several human studies have reported an inverse association between male testosterone and phthalate levels. Our aim was to investigate time to pregnancy (TTP) according to serum levels of diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) metabolites in both partners. In 2002-2004 we enrolled 938 pregnant women and 401 male spouses from Greenland, Poland and Ukraine. Six oxidized metabolites of DEHP and DiNP were summarized for each of the two parent compounds to provide proxies of the internal exposure. We used Cox discrete-time models to estimate fecundability ratios (FR) and 95% confidence intervals (95% CIs) for men and women according to their proxy-DEHP or -DiNP serum levels adjusted for a fixed set of covariates. The FR was slightly elevated among women with high levels of DEHP (FR=1.14, 95% CI 1.00;1.30) suggesting a shorter TTP in these women. The FR was unrelated to DiNP in women, whereas the results for men were inconsistent pointing in opposite directions. First-time pregnant women from Greenland with high serum DiNP levels had a longer TTP. This study spanning large contrast in environmental exposure does not indicate adverse effects of phthalates on couple fecundity. The shorter TTP in women with high levels of DEHP metabolites is unexplained and needs further investigation. |
format |
Article in Journal/Newspaper |
author |
Specht, Ina Olmer Bonde, Jens Peter Toft, Gunnar Lindh, Christian Jönsson, Bo A Jørgensen, Kristian T |
author_facet |
Specht, Ina Olmer Bonde, Jens Peter Toft, Gunnar Lindh, Christian Jönsson, Bo A Jørgensen, Kristian T |
author_sort |
Specht, Ina Olmer |
title |
Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
title_short |
Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
title_full |
Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
title_fullStr |
Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
title_full_unstemmed |
Serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
title_sort |
serum phthalate levels and time to pregnancy in couples from greenland, poland and ukraine. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://lup.lub.lu.se/record/5258193 https://doi.org/10.1371/journal.pone.0120070 https://portal.research.lu.se/files/3708534/8255499 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
PLoS ONE; 10(3), no e0120070 (2015) ISSN: 1932-6203 |
op_relation |
https://lup.lub.lu.se/record/5258193 http://dx.doi.org/10.1371/journal.pone.0120070 https://portal.research.lu.se/files/3708534/8255499 pmid:25786246 wos:000352138500153 scopus:84925438707 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0120070 |
container_title |
PLOS ONE |
container_volume |
10 |
container_issue |
3 |
container_start_page |
e0120070 |
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