Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water
Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The...
Published in: | Scandinavian Journal of Gastroenterology |
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Taylor & Francis
2019
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Online Access: | https://lup.lub.lu.se/record/266b8326-e39d-434a-bde8-f39746a822fe https://doi.org/10.1080/00365521.2019.1674374 |
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ftulundlup:oai:lup.lub.lu.se:266b8326-e39d-434a-bde8-f39746a822fe 2024-04-28T08:18:25+00:00 Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water Segerman, Fredrik Clarkson, Spencer Sjöberg, Klas 2019-10-15 https://lup.lub.lu.se/record/266b8326-e39d-434a-bde8-f39746a822fe https://doi.org/10.1080/00365521.2019.1674374 eng eng Taylor & Francis https://lup.lub.lu.se/record/266b8326-e39d-434a-bde8-f39746a822fe http://dx.doi.org/10.1080/00365521.2019.1674374 scopus:85074575507 pmid:31613652 Scandinavian Journal of Gastroenterology; 54(10), pp 1250-1260 (2019) ISSN: 0036-5521 Gastroenterology and Hepatology Public Health Global Health Social Medicine and Epidemiology Crohn’s disease drinking water epidemiology prevalence ulcerative colitis contributiontojournal/article info:eu-repo/semantics/article text 2019 ftulundlup https://doi.org/10.1080/00365521.2019.1674374 2024-04-03T14:04:00Z Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The aim was to investigate the incidence and prevalence of IBD in the 33 municipalities in the county Scania in Southern Sweden, an area comprising 100 × 100 km with 1,274,069 inhabitants. Furthermore, we wanted to explore whether compounds in the drinking water could contribute to IBD; one report from Norway has suggested that iron in drinking water could contribute to UC. Methods: Patients with CD and UC were identified through the ICD-10 diagnosis database during the period 2000–2013. Water analyses for pH, alkaline, nitrate, sulphate, iron, magnesium and calcium were based on established methods and compared with the prevalence of IBD using Student’s t-test. Results: A total number of 8925 patients were identified. The incidence for CD and UC were high (mean 16.4/105, range 13.6–17.9 and 25.3/105, range 21.3–28.0, respectively). The prevalence varied substantially (p <.0001 for both; CD mean 0.30%, range 0.15–0.42 and UC mean 0.42%, range 0.32–0.56). No correlation between IBD and the chemical compounds in the drinking water could be shown. Conclusions: The incidence rates of both CD and UC were high. The prevalence varied from 200% to 300% between the municipalities, despite the limited geographical area indicating that local conditions are of importance. However, chemical compounds in the water were not associated with this variation. Article in Journal/Newspaper Faroe Islands Lund University Publications (LUP) Scandinavian Journal of Gastroenterology 54 10 1250 1260 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Gastroenterology and Hepatology Public Health Global Health Social Medicine and Epidemiology Crohn’s disease drinking water epidemiology prevalence ulcerative colitis |
spellingShingle |
Gastroenterology and Hepatology Public Health Global Health Social Medicine and Epidemiology Crohn’s disease drinking water epidemiology prevalence ulcerative colitis Segerman, Fredrik Clarkson, Spencer Sjöberg, Klas Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
topic_facet |
Gastroenterology and Hepatology Public Health Global Health Social Medicine and Epidemiology Crohn’s disease drinking water epidemiology prevalence ulcerative colitis |
description |
Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The aim was to investigate the incidence and prevalence of IBD in the 33 municipalities in the county Scania in Southern Sweden, an area comprising 100 × 100 km with 1,274,069 inhabitants. Furthermore, we wanted to explore whether compounds in the drinking water could contribute to IBD; one report from Norway has suggested that iron in drinking water could contribute to UC. Methods: Patients with CD and UC were identified through the ICD-10 diagnosis database during the period 2000–2013. Water analyses for pH, alkaline, nitrate, sulphate, iron, magnesium and calcium were based on established methods and compared with the prevalence of IBD using Student’s t-test. Results: A total number of 8925 patients were identified. The incidence for CD and UC were high (mean 16.4/105, range 13.6–17.9 and 25.3/105, range 21.3–28.0, respectively). The prevalence varied substantially (p <.0001 for both; CD mean 0.30%, range 0.15–0.42 and UC mean 0.42%, range 0.32–0.56). No correlation between IBD and the chemical compounds in the drinking water could be shown. Conclusions: The incidence rates of both CD and UC were high. The prevalence varied from 200% to 300% between the municipalities, despite the limited geographical area indicating that local conditions are of importance. However, chemical compounds in the water were not associated with this variation. |
format |
Article in Journal/Newspaper |
author |
Segerman, Fredrik Clarkson, Spencer Sjöberg, Klas |
author_facet |
Segerman, Fredrik Clarkson, Spencer Sjöberg, Klas |
author_sort |
Segerman, Fredrik |
title |
Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
title_short |
Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
title_full |
Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
title_fullStr |
Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
title_full_unstemmed |
Marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
title_sort |
marked regional variations in the prevalence of inflammatory bowel disease in a limited geographical region are not associated with compounds in the drinking water |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
https://lup.lub.lu.se/record/266b8326-e39d-434a-bde8-f39746a822fe https://doi.org/10.1080/00365521.2019.1674374 |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Scandinavian Journal of Gastroenterology; 54(10), pp 1250-1260 (2019) ISSN: 0036-5521 |
op_relation |
https://lup.lub.lu.se/record/266b8326-e39d-434a-bde8-f39746a822fe http://dx.doi.org/10.1080/00365521.2019.1674374 scopus:85074575507 pmid:31613652 |
op_doi |
https://doi.org/10.1080/00365521.2019.1674374 |
container_title |
Scandinavian Journal of Gastroenterology |
container_volume |
54 |
container_issue |
10 |
container_start_page |
1250 |
op_container_end_page |
1260 |
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1797582434030583808 |