Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme
Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Me...
Published in: | The Lancet Psychiatry |
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2022
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Online Access: | https://lup.lub.lu.se/record/2625a6d9-5c6f-4c54-ba13-44a1be463c49 https://doi.org/10.1016/S2215-0366(21)00387-4 |
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ftulundlup:oai:lup.lub.lu.se:2625a6d9-5c6f-4c54-ba13-44a1be463c49 2024-05-19T07:43:02+00:00 Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme Frederiksen, Line Elmerdahl Erdmann, Friederike Mader, Luzius Mogensen, Hanna Pedersen, Camilla Kenborg, Line Bautz, Andrea Talbäck, Mats Hirvonen, Elli Nielsen, Thomas Tjørnelund Andersen, Elisabeth Anne Wreford Holmqvist, Anna Sällfors Jørgensen, Ole Sylvester Jepsen, Jens Richardt Møllegaard Malila, Nea Hasle, Henrik Madanat-Harjuoja, Laura Feychting, Maria Winther, Jeanette Falck 2022-01 https://lup.lub.lu.se/record/2625a6d9-5c6f-4c54-ba13-44a1be463c49 https://doi.org/10.1016/S2215-0366(21)00387-4 eng eng Elsevier https://lup.lub.lu.se/record/2625a6d9-5c6f-4c54-ba13-44a1be463c49 http://dx.doi.org/10.1016/S2215-0366(21)00387-4 scopus:85121147416 pmid:34822758 The Lancet Psychiatry; 9(1), pp 35-45 (2022) ISSN: 2215-0366 Cancer and Oncology Psychiatry Pediatrics contributiontojournal/article info:eu-repo/semantics/article text 2022 ftulundlup https://doi.org/10.1016/S2215-0366(21)00387-4 2024-04-23T23:49:15Z Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life after Childhood Cancer [SALiCCS] research programme), we included 5-year survivors of childhood cancer diagnosed before 20 years of age between Jan 1, 1974 and Dec 31, 2011, in Denmark, Finland, and Sweden. In Denmark and Sweden, 94·7% of individuals were born in a Nordic country (ie, Denmark, Finland, Iceland, Norway, or Sweden); similar information was not available in Finland. Data on ethnicity were not collected. Survivors were compared with their siblings and randomly selected individuals from the general population who were matched to the survivors by year of birth, sex, and geographical region. We followed up our study population from 5 years after the childhood cancer diagnosis or corresponding calendar date for matched individuals (the index date) until Aug 11, 2017, and assessed information on hospital contacts for any and specific psychiatric disorders. For siblings, the index date was defined as 5 years from the date on which they were of the same age as their sibling survivor when diagnosed with cancer. Findings: The study population included 18 621 childhood cancer survivors (9934 [53·3%] males and 8687 [46·7%] females), 24 775 siblings (12 594 [50·8%] males and 12 181 [49·2%] females), and 88 630 matched individuals (47 300 [53·4%] males and 41 330 [46·6%] females). The cumulative incidence proportion of having had a psychiatric hospital contact by 30 years of age between Jan 1, 1979, and Aug 11, 2017, was 15·9% (95% CI 15·3–16·5) for childhood cancer survivors, 14·0% (13·5–14·5) for siblings, and 12·7% (12·4–12·9) for matched individuals. Despite a small absolute difference, survivors were at higher ... Article in Journal/Newspaper Iceland Lund University Publications (LUP) The Lancet Psychiatry 9 1 35 45 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology Psychiatry Pediatrics |
spellingShingle |
Cancer and Oncology Psychiatry Pediatrics Frederiksen, Line Elmerdahl Erdmann, Friederike Mader, Luzius Mogensen, Hanna Pedersen, Camilla Kenborg, Line Bautz, Andrea Talbäck, Mats Hirvonen, Elli Nielsen, Thomas Tjørnelund Andersen, Elisabeth Anne Wreford Holmqvist, Anna Sällfors Jørgensen, Ole Sylvester Jepsen, Jens Richardt Møllegaard Malila, Nea Hasle, Henrik Madanat-Harjuoja, Laura Feychting, Maria Winther, Jeanette Falck Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
topic_facet |
Cancer and Oncology Psychiatry Pediatrics |
description |
Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life after Childhood Cancer [SALiCCS] research programme), we included 5-year survivors of childhood cancer diagnosed before 20 years of age between Jan 1, 1974 and Dec 31, 2011, in Denmark, Finland, and Sweden. In Denmark and Sweden, 94·7% of individuals were born in a Nordic country (ie, Denmark, Finland, Iceland, Norway, or Sweden); similar information was not available in Finland. Data on ethnicity were not collected. Survivors were compared with their siblings and randomly selected individuals from the general population who were matched to the survivors by year of birth, sex, and geographical region. We followed up our study population from 5 years after the childhood cancer diagnosis or corresponding calendar date for matched individuals (the index date) until Aug 11, 2017, and assessed information on hospital contacts for any and specific psychiatric disorders. For siblings, the index date was defined as 5 years from the date on which they were of the same age as their sibling survivor when diagnosed with cancer. Findings: The study population included 18 621 childhood cancer survivors (9934 [53·3%] males and 8687 [46·7%] females), 24 775 siblings (12 594 [50·8%] males and 12 181 [49·2%] females), and 88 630 matched individuals (47 300 [53·4%] males and 41 330 [46·6%] females). The cumulative incidence proportion of having had a psychiatric hospital contact by 30 years of age between Jan 1, 1979, and Aug 11, 2017, was 15·9% (95% CI 15·3–16·5) for childhood cancer survivors, 14·0% (13·5–14·5) for siblings, and 12·7% (12·4–12·9) for matched individuals. Despite a small absolute difference, survivors were at higher ... |
format |
Article in Journal/Newspaper |
author |
Frederiksen, Line Elmerdahl Erdmann, Friederike Mader, Luzius Mogensen, Hanna Pedersen, Camilla Kenborg, Line Bautz, Andrea Talbäck, Mats Hirvonen, Elli Nielsen, Thomas Tjørnelund Andersen, Elisabeth Anne Wreford Holmqvist, Anna Sällfors Jørgensen, Ole Sylvester Jepsen, Jens Richardt Møllegaard Malila, Nea Hasle, Henrik Madanat-Harjuoja, Laura Feychting, Maria Winther, Jeanette Falck |
author_facet |
Frederiksen, Line Elmerdahl Erdmann, Friederike Mader, Luzius Mogensen, Hanna Pedersen, Camilla Kenborg, Line Bautz, Andrea Talbäck, Mats Hirvonen, Elli Nielsen, Thomas Tjørnelund Andersen, Elisabeth Anne Wreford Holmqvist, Anna Sällfors Jørgensen, Ole Sylvester Jepsen, Jens Richardt Møllegaard Malila, Nea Hasle, Henrik Madanat-Harjuoja, Laura Feychting, Maria Winther, Jeanette Falck |
author_sort |
Frederiksen, Line Elmerdahl |
title |
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
title_short |
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
title_full |
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
title_fullStr |
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
title_full_unstemmed |
Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden : a register-based cohort study from the SALiCCS research programme |
title_sort |
psychiatric disorders in childhood cancer survivors in denmark, finland, and sweden : a register-based cohort study from the saliccs research programme |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://lup.lub.lu.se/record/2625a6d9-5c6f-4c54-ba13-44a1be463c49 https://doi.org/10.1016/S2215-0366(21)00387-4 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
The Lancet Psychiatry; 9(1), pp 35-45 (2022) ISSN: 2215-0366 |
op_relation |
https://lup.lub.lu.se/record/2625a6d9-5c6f-4c54-ba13-44a1be463c49 http://dx.doi.org/10.1016/S2215-0366(21)00387-4 scopus:85121147416 pmid:34822758 |
op_doi |
https://doi.org/10.1016/S2215-0366(21)00387-4 |
container_title |
The Lancet Psychiatry |
container_volume |
9 |
container_issue |
1 |
container_start_page |
35 |
op_container_end_page |
45 |
_version_ |
1799482745460621312 |