Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors
Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the mos...
Published in: | PLOS Medicine |
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2017
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Online Access: | https://lup.lub.lu.se/record/1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 https://doi.org/10.1371/journal.pmed.1002296 |
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ftulundlup:oai:lup.lub.lu.se:1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 2024-05-12T08:05:44+00:00 Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F Olsen, Jørgen H 2017-05-01 https://lup.lub.lu.se/record/1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 https://doi.org/10.1371/journal.pmed.1002296 eng eng Public Library of Science (PLoS) https://lup.lub.lu.se/record/1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 http://dx.doi.org/10.1371/journal.pmed.1002296 wos:000402532900005 pmid:28486495 scopus:85020126963 PLoS Medicine; 14(5), no e1002296 (2017) ISSN: 1549-1277 Cancer and Oncology contributiontojournal/article info:eu-repo/semantics/article text 2017 ftulundlup https://doi.org/10.1371/journal.pmed.1002296 2024-04-17T14:05:42Z Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Methods and findings: From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943–2008 in Denmark, 1971–2008 in Finland, 1955–2008 in Iceland, and 1958–2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977–2010; Finland, 1975–2012; Iceland, 1999–2008; and Sweden, 1968–2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors’ standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0–42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91–1.97). The AER was 3,068 (2,980–3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all ... Article in Journal/Newspaper Iceland Lund University Publications (LUP) PLOS Medicine 14 5 e1002296 |
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Open Polar |
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Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Cancer and Oncology |
spellingShingle |
Cancer and Oncology de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F Olsen, Jørgen H Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
topic_facet |
Cancer and Oncology |
description |
Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Methods and findings: From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943–2008 in Denmark, 1971–2008 in Finland, 1955–2008 in Iceland, and 1958–2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977–2010; Finland, 1975–2012; Iceland, 1999–2008; and Sweden, 1968–2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors’ standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0–42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91–1.97). The AER was 3,068 (2,980–3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all ... |
format |
Article in Journal/Newspaper |
author |
de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F Olsen, Jørgen H |
author_facet |
de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F Olsen, Jørgen H |
author_sort |
de Fine Licht, Sofie |
title |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
title_short |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
title_full |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
title_fullStr |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
title_full_unstemmed |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study : A cohort study of 21,297 childhood cancer survivors |
title_sort |
long-term inpatient disease burden in the adult life after childhood cancer in scandinavia (aliccs) study : a cohort study of 21,297 childhood cancer survivors |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://lup.lub.lu.se/record/1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 https://doi.org/10.1371/journal.pmed.1002296 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
PLoS Medicine; 14(5), no e1002296 (2017) ISSN: 1549-1277 |
op_relation |
https://lup.lub.lu.se/record/1d36bbd9-723c-482a-b6c1-d3f9a7e75f88 http://dx.doi.org/10.1371/journal.pmed.1002296 wos:000402532900005 pmid:28486495 scopus:85020126963 |
op_doi |
https://doi.org/10.1371/journal.pmed.1002296 |
container_title |
PLOS Medicine |
container_volume |
14 |
container_issue |
5 |
container_start_page |
e1002296 |
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1798848105404170240 |