Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) a...
Published in: | Environmental Health |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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BioMed Central (BMC)
2015
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Online Access: | https://lup.lub.lu.se/record/5179939 https://doi.org/10.1186/1476-069X-14-2 https://portal.research.lu.se/files/3483194/8053186 |
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ftulundlup:oai:lup.lub.lu.se:1c185604-7e02-4b2f-b588-b057ac4a88e7 2023-05-15T16:28:39+02:00 Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Obel, Carsten Pedersen, Henning Sloth Hernik, Agnieszka Ogniev, Victor Jönsson, Bo A Lindh, Christian Rylander, Lars Rignell-Hydbom, Anna Bonde, Jens Peter Toft, Gunnar 2015 application/pdf https://lup.lub.lu.se/record/5179939 https://doi.org/10.1186/1476-069X-14-2 https://portal.research.lu.se/files/3483194/8053186 eng eng BioMed Central (BMC) https://lup.lub.lu.se/record/5179939 http://dx.doi.org/10.1186/1476-069X-14-2 https://portal.research.lu.se/files/3483194/8053186 wos:000349477400001 pmid:25567242 scopus:84988964939 info:eu-repo/semantics/openAccess Environmental Health; 14(2), pp 1-11 (2015) ISSN: 1476-069X Environmental Health and Occupational Health Behaviour Child Child development Cohort study Motor development Perfluorooctanoate (PFOA) Perfluorooctane sulfonate (PFOS) Prenatal exposure Delayed effects contributiontojournal/article info:eu-repo/semantics/article text 2015 ftulundlup https://doi.org/10.1186/1476-069X-14-2 2023-02-01T23:35:36Z Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010-2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses. Results: In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (beta (95% CI) = 1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (beta (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties. Conclusions: Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children's neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest ... Article in Journal/Newspaper Greenland Lund University Publications (LUP) Greenland Environmental Health 14 1 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Environmental Health and Occupational Health Behaviour Child Child development Cohort study Motor development Perfluorooctanoate (PFOA) Perfluorooctane sulfonate (PFOS) Prenatal exposure Delayed effects |
spellingShingle |
Environmental Health and Occupational Health Behaviour Child Child development Cohort study Motor development Perfluorooctanoate (PFOA) Perfluorooctane sulfonate (PFOS) Prenatal exposure Delayed effects Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Obel, Carsten Pedersen, Henning Sloth Hernik, Agnieszka Ogniev, Victor Jönsson, Bo A Lindh, Christian Rylander, Lars Rignell-Hydbom, Anna Bonde, Jens Peter Toft, Gunnar Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
topic_facet |
Environmental Health and Occupational Health Behaviour Child Child development Cohort study Motor development Perfluorooctanoate (PFOA) Perfluorooctane sulfonate (PFOS) Prenatal exposure Delayed effects |
description |
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010-2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses. Results: In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (beta (95% CI) = 1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (beta (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties. Conclusions: Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children's neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest ... |
format |
Article in Journal/Newspaper |
author |
Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Obel, Carsten Pedersen, Henning Sloth Hernik, Agnieszka Ogniev, Victor Jönsson, Bo A Lindh, Christian Rylander, Lars Rignell-Hydbom, Anna Bonde, Jens Peter Toft, Gunnar |
author_facet |
Hoyer, Birgit Bjerre Ramlau-Hansen, Cecilia Host Obel, Carsten Pedersen, Henning Sloth Hernik, Agnieszka Ogniev, Victor Jönsson, Bo A Lindh, Christian Rylander, Lars Rignell-Hydbom, Anna Bonde, Jens Peter Toft, Gunnar |
author_sort |
Hoyer, Birgit Bjerre |
title |
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
title_short |
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
title_full |
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
title_fullStr |
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
title_full_unstemmed |
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
title_sort |
pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study |
publisher |
BioMed Central (BMC) |
publishDate |
2015 |
url |
https://lup.lub.lu.se/record/5179939 https://doi.org/10.1186/1476-069X-14-2 https://portal.research.lu.se/files/3483194/8053186 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Environmental Health; 14(2), pp 1-11 (2015) ISSN: 1476-069X |
op_relation |
https://lup.lub.lu.se/record/5179939 http://dx.doi.org/10.1186/1476-069X-14-2 https://portal.research.lu.se/files/3483194/8053186 wos:000349477400001 pmid:25567242 scopus:84988964939 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/1476-069X-14-2 |
container_title |
Environmental Health |
container_volume |
14 |
container_issue |
1 |
_version_ |
1766018321758552064 |