Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis
Candida antarctica lipase B, immobilized as cross linked enzyme aggregates (CLEAs) was used to mediate the Baeyer-Villiger oxidation of cyclohexanone to epsilon-caprolactone, and the reaction was compared with the one using Novozym (R) 435 as catalyst. The conversion was dependent on the initial con...
Published in: | Journal of Molecular Catalysis B: Enzymatic |
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Online Access: | https://lup.lub.lu.se/record/3669846 https://doi.org/10.1016/j.molcatb.2012.12.007 |
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ftulundlup:oai:lup.lub.lu.se:0809f698-973e-48fe-a727-7eefea5fb383 2023-05-15T13:50:27+02:00 Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis Chávez, Georgina Hatti-Kaul, Rajni Sheldon, Roger A. Mamo, Gashaw 2013 https://lup.lub.lu.se/record/3669846 https://doi.org/10.1016/j.molcatb.2012.12.007 eng eng Elsevier https://lup.lub.lu.se/record/3669846 http://dx.doi.org/10.1016/j.molcatb.2012.12.007 wos:000315552300011 scopus:84872977574 Journal of Molecular Catalysis B: Enzymatic; 89, pp 67-72 (2013) ISSN: 1873-3158 Industrial Biotechnology Lipase CLEAs Baeyer-Villiger oxidation epsilon-Caprolactone contributiontojournal/article info:eu-repo/semantics/article text 2013 ftulundlup https://doi.org/10.1016/j.molcatb.2012.12.007 2023-02-01T23:28:58Z Candida antarctica lipase B, immobilized as cross linked enzyme aggregates (CLEAs) was used to mediate the Baeyer-Villiger oxidation of cyclohexanone to epsilon-caprolactone, and the reaction was compared with the one using Novozym (R) 435 as catalyst. The conversion was dependent on the initial concentration of cyclohexanone, and was about 90% after 48 h at concentrations of up to 0.25 M but was decreased at higher concentrations. Caprolactone concentrations up to 0.6 M had no effect on the reaction efficiency. Among the cyclic ketones tested, the highest degree of conversion was achieved for cyclopentanone (88%) and the lowest for cyclooctanone (about 2%). The effect of methyl substitution and position of substitution on the cycloketone was studied using methylcyclohexanone and it has shown to influence the conversion efficiency. Both hydrogen peroxide and the reaction by-product acetic acid had a deleterious effect on the stability of the biocatalyst. (C) 2012 Elsevier B.V. All rights reserved. Article in Journal/Newspaper Antarc* Antarctica Lund University Publications (LUP) Journal of Molecular Catalysis B: Enzymatic 89 67 72 |
institution |
Open Polar |
collection |
Lund University Publications (LUP) |
op_collection_id |
ftulundlup |
language |
English |
topic |
Industrial Biotechnology Lipase CLEAs Baeyer-Villiger oxidation epsilon-Caprolactone |
spellingShingle |
Industrial Biotechnology Lipase CLEAs Baeyer-Villiger oxidation epsilon-Caprolactone Chávez, Georgina Hatti-Kaul, Rajni Sheldon, Roger A. Mamo, Gashaw Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
topic_facet |
Industrial Biotechnology Lipase CLEAs Baeyer-Villiger oxidation epsilon-Caprolactone |
description |
Candida antarctica lipase B, immobilized as cross linked enzyme aggregates (CLEAs) was used to mediate the Baeyer-Villiger oxidation of cyclohexanone to epsilon-caprolactone, and the reaction was compared with the one using Novozym (R) 435 as catalyst. The conversion was dependent on the initial concentration of cyclohexanone, and was about 90% after 48 h at concentrations of up to 0.25 M but was decreased at higher concentrations. Caprolactone concentrations up to 0.6 M had no effect on the reaction efficiency. Among the cyclic ketones tested, the highest degree of conversion was achieved for cyclopentanone (88%) and the lowest for cyclooctanone (about 2%). The effect of methyl substitution and position of substitution on the cycloketone was studied using methylcyclohexanone and it has shown to influence the conversion efficiency. Both hydrogen peroxide and the reaction by-product acetic acid had a deleterious effect on the stability of the biocatalyst. (C) 2012 Elsevier B.V. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Chávez, Georgina Hatti-Kaul, Rajni Sheldon, Roger A. Mamo, Gashaw |
author_facet |
Chávez, Georgina Hatti-Kaul, Rajni Sheldon, Roger A. Mamo, Gashaw |
author_sort |
Chávez, Georgina |
title |
Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
title_short |
Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
title_full |
Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
title_fullStr |
Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
title_full_unstemmed |
Baeyer-Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis |
title_sort |
baeyer-villiger oxidation with peracid generated in situ by calb-clea catalyzed perhydrolysis |
publisher |
Elsevier |
publishDate |
2013 |
url |
https://lup.lub.lu.se/record/3669846 https://doi.org/10.1016/j.molcatb.2012.12.007 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Journal of Molecular Catalysis B: Enzymatic; 89, pp 67-72 (2013) ISSN: 1873-3158 |
op_relation |
https://lup.lub.lu.se/record/3669846 http://dx.doi.org/10.1016/j.molcatb.2012.12.007 wos:000315552300011 scopus:84872977574 |
op_doi |
https://doi.org/10.1016/j.molcatb.2012.12.007 |
container_title |
Journal of Molecular Catalysis B: Enzymatic |
container_volume |
89 |
container_start_page |
67 |
op_container_end_page |
72 |
_version_ |
1766253511880736768 |