Prenatal glucocorticoid treatment and later mental health in children and adolescents
Abstract Background Animal studies demonstrate a clear link between prenatal exposure to glucocorticoids (GC) and altered offspring brain development. We aim to examine whether prenatal GC exposure programs long-term mental health in humans. Methods Using propensity-score-matching, children prenatal...
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ftulincoln:oai:eprints.lincoln.ac.uk:22952 2023-05-15T17:42:51+02:00 Prenatal glucocorticoid treatment and later mental health in children and adolescents Khalife, Natasha Glover, Vivette Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina 2013-11-22 application/pdf https://eprints.lincoln.ac.uk/id/eprint/22952/ https://eprints.lincoln.ac.uk/id/eprint/22952/1/22952%20journal.pone.0081394.PDF https://doi.org/10.1371/journal.pone.0081394 en eng Public Library of Science https://eprints.lincoln.ac.uk/id/eprint/22952/1/22952%20journal.pone.0081394.PDF Khalife, Natasha, Glover, Vivette, Taanila, Anja, Ebeling, Hanna, Järvelin, Marjo-Riitta and Rodriguez, Alina (2013) Prenatal glucocorticoid treatment and later mental health in children and adolescents. PLoS ONE, 8 (11). e81394. ISSN 1932-6203 doi:10.1371/journal.pone.0081394 C800 Psychology Article PeerReviewed 2013 ftulincoln https://doi.org/10.1371/journal.pone.0081394 2022-03-02T20:05:36Z Abstract Background Animal studies demonstrate a clear link between prenatal exposure to glucocorticoids (GC) and altered offspring brain development. We aim to examine whether prenatal GC exposure programs long-term mental health in humans. Methods Using propensity-score-matching, children prenatally exposed to synthetic glucocorticoids (sGC), n=37, and controls, n=185, were balanced on important confounders related to sGC treatment - gestational age and pre-pregnancy BMI. We also used mixed-effects modeling to analyse the entire cohort – matching each sGC case, n=37, to all possible controls, n=6079, on gestational age and sex. We obtained data from the Northern Finland Birth Cohort 1986 at four waves – pregnancy, birth, 8 and 16 years. Data on pregnancy and birth outcomes came from medical records. Mental health was assessed at 8 years by teachers with the Rutter B2 scale, and at 16 years by parents with the Strengths and Weaknesses of ADHD symptoms and Normal behavior (SWAN) scale and adolescents by the Youth Self-Report (YSR) scale. Results Prenatal sGC treatment was consistently associated with adverse mental health in childhood and adolescence, as shown by both the propensity-score method and mixed-effects model. Using the propensity-score-matched subsample, linear multiple regression showed prenatal sGC was significantly linked with general psychiatric disturbance (B=8.34 [95% CI: .23-16.45]) and inattention (B= .97 [95% CI: .16-1.80]) at 8 years after control for relevant confounders. Similar findings were obtained at 16 years, but did not reach statistical significance. Mediation by birthweight/placental weight was not detected. Conclusions This study is the first to prospectively investigate the long-term associations between prenatal exposure to sGC treatment and mental health in children and adolescents. We report an association between prenatal exposure to sGC and child mental health, supportive of the idea that sGC has a programming effect on the fetal brain. Article in Journal/Newspaper Northern Finland University of Lincoln: Lincoln Repository PLoS ONE 8 11 e81394 |
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University of Lincoln: Lincoln Repository |
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ftulincoln |
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English |
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C800 Psychology |
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C800 Psychology Khalife, Natasha Glover, Vivette Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina Prenatal glucocorticoid treatment and later mental health in children and adolescents |
topic_facet |
C800 Psychology |
description |
Abstract Background Animal studies demonstrate a clear link between prenatal exposure to glucocorticoids (GC) and altered offspring brain development. We aim to examine whether prenatal GC exposure programs long-term mental health in humans. Methods Using propensity-score-matching, children prenatally exposed to synthetic glucocorticoids (sGC), n=37, and controls, n=185, were balanced on important confounders related to sGC treatment - gestational age and pre-pregnancy BMI. We also used mixed-effects modeling to analyse the entire cohort – matching each sGC case, n=37, to all possible controls, n=6079, on gestational age and sex. We obtained data from the Northern Finland Birth Cohort 1986 at four waves – pregnancy, birth, 8 and 16 years. Data on pregnancy and birth outcomes came from medical records. Mental health was assessed at 8 years by teachers with the Rutter B2 scale, and at 16 years by parents with the Strengths and Weaknesses of ADHD symptoms and Normal behavior (SWAN) scale and adolescents by the Youth Self-Report (YSR) scale. Results Prenatal sGC treatment was consistently associated with adverse mental health in childhood and adolescence, as shown by both the propensity-score method and mixed-effects model. Using the propensity-score-matched subsample, linear multiple regression showed prenatal sGC was significantly linked with general psychiatric disturbance (B=8.34 [95% CI: .23-16.45]) and inattention (B= .97 [95% CI: .16-1.80]) at 8 years after control for relevant confounders. Similar findings were obtained at 16 years, but did not reach statistical significance. Mediation by birthweight/placental weight was not detected. Conclusions This study is the first to prospectively investigate the long-term associations between prenatal exposure to sGC treatment and mental health in children and adolescents. We report an association between prenatal exposure to sGC and child mental health, supportive of the idea that sGC has a programming effect on the fetal brain. |
format |
Article in Journal/Newspaper |
author |
Khalife, Natasha Glover, Vivette Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina |
author_facet |
Khalife, Natasha Glover, Vivette Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina |
author_sort |
Khalife, Natasha |
title |
Prenatal glucocorticoid treatment and later mental health in children and adolescents |
title_short |
Prenatal glucocorticoid treatment and later mental health in children and adolescents |
title_full |
Prenatal glucocorticoid treatment and later mental health in children and adolescents |
title_fullStr |
Prenatal glucocorticoid treatment and later mental health in children and adolescents |
title_full_unstemmed |
Prenatal glucocorticoid treatment and later mental health in children and adolescents |
title_sort |
prenatal glucocorticoid treatment and later mental health in children and adolescents |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
https://eprints.lincoln.ac.uk/id/eprint/22952/ https://eprints.lincoln.ac.uk/id/eprint/22952/1/22952%20journal.pone.0081394.PDF https://doi.org/10.1371/journal.pone.0081394 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://eprints.lincoln.ac.uk/id/eprint/22952/1/22952%20journal.pone.0081394.PDF Khalife, Natasha, Glover, Vivette, Taanila, Anja, Ebeling, Hanna, Järvelin, Marjo-Riitta and Rodriguez, Alina (2013) Prenatal glucocorticoid treatment and later mental health in children and adolescents. PLoS ONE, 8 (11). e81394. ISSN 1932-6203 doi:10.1371/journal.pone.0081394 |
op_doi |
https://doi.org/10.1371/journal.pone.0081394 |
container_title |
PLoS ONE |
container_volume |
8 |
container_issue |
11 |
container_start_page |
e81394 |
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