Placental size Is associated with mental health in children and adolescents
Background The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of ag...
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ftulincoln:oai:eprints.lincoln.ac.uk:22928 2023-05-15T17:42:41+02:00 Placental size Is associated with mental health in children and adolescents Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina 2012-07-09 application/pdf https://eprints.lincoln.ac.uk/id/eprint/22928/ https://eprints.lincoln.ac.uk/id/eprint/22928/1/22928%20journal.pone.0040534.PDF https://doi.org/10.1371/journal.pone.0040534 en eng Public Library of Science https://eprints.lincoln.ac.uk/id/eprint/22928/1/22928%20journal.pone.0040534.PDF Khalife, Natasha, Glover, Vivette, Hartikainen, Anna-Liisa, Taanila, Anja, Ebeling, Hanna, Järvelin, Marjo-Riitta, Rodriguez, Alina and UNSPECIFIED (2012) Placental size Is associated with mental health in children and adolescents. PLoS ONE, 7 (7). e40534. ISSN 1932-6203 doi:10.1371/journal.pone.0040534 cc_by CC-BY C800 Psychology Article PeerReviewed 2012 ftulincoln https://doi.org/10.1371/journal.pone.0040534 2022-03-02T20:05:31Z Background The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years. Methodology/Principal Findings Prospective data were obtained from The Northern Finland Birth Cohort (NFBC) 1986. Placental weight, surface area and birth weight were measured according to standard procedures, within 30 minutes after birth. ADHD symptoms, probable psychiatric disturbance, antisocial disorder and neurotic disorder were assessed at 8 years (n = 8101), and ADHD symptoms were assessed again at 16 years (n = 6607), by teachers and parents respectively. We used logistic regression analyses to investigate the association between placental size and mental health outcomes, and controlled for gestational age, birth weight, socio-demographic factors and medical factors, during gestation. There were significant positive associations between placental size (weight, surface area and placental-to-birth-weight ratio) and mental health problems in boys at 8 and 16 years of age. Increased placental weight was linked with overall probable psychiatric disturbance (at 8y, OR = 1.14 [95% CI = 1.04–1.25]), antisocial behavior (at 8 y, OR = 1.14 [95% CI = 1.03–1.27]) and ADHD symptoms (inattention-hyperactivity at 16y, OR = 1.19 [95% CI = 1.02–1.38]). No significant associations were detected among girls. Conclusions/Significance Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. Article in Journal/Newspaper Northern Finland University of Lincoln: Lincoln Repository PLoS ONE 7 7 e40534 |
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University of Lincoln: Lincoln Repository |
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ftulincoln |
language |
English |
topic |
C800 Psychology |
spellingShingle |
C800 Psychology Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina Placental size Is associated with mental health in children and adolescents |
topic_facet |
C800 Psychology |
description |
Background The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years. Methodology/Principal Findings Prospective data were obtained from The Northern Finland Birth Cohort (NFBC) 1986. Placental weight, surface area and birth weight were measured according to standard procedures, within 30 minutes after birth. ADHD symptoms, probable psychiatric disturbance, antisocial disorder and neurotic disorder were assessed at 8 years (n = 8101), and ADHD symptoms were assessed again at 16 years (n = 6607), by teachers and parents respectively. We used logistic regression analyses to investigate the association between placental size and mental health outcomes, and controlled for gestational age, birth weight, socio-demographic factors and medical factors, during gestation. There were significant positive associations between placental size (weight, surface area and placental-to-birth-weight ratio) and mental health problems in boys at 8 and 16 years of age. Increased placental weight was linked with overall probable psychiatric disturbance (at 8y, OR = 1.14 [95% CI = 1.04–1.25]), antisocial behavior (at 8 y, OR = 1.14 [95% CI = 1.03–1.27]) and ADHD symptoms (inattention-hyperactivity at 16y, OR = 1.19 [95% CI = 1.02–1.38]). No significant associations were detected among girls. Conclusions/Significance Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. |
format |
Article in Journal/Newspaper |
author |
Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina |
author_facet |
Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Järvelin, Marjo-Riitta Rodriguez, Alina |
author_sort |
Khalife, Natasha |
title |
Placental size Is associated with mental health in children and adolescents |
title_short |
Placental size Is associated with mental health in children and adolescents |
title_full |
Placental size Is associated with mental health in children and adolescents |
title_fullStr |
Placental size Is associated with mental health in children and adolescents |
title_full_unstemmed |
Placental size Is associated with mental health in children and adolescents |
title_sort |
placental size is associated with mental health in children and adolescents |
publisher |
Public Library of Science |
publishDate |
2012 |
url |
https://eprints.lincoln.ac.uk/id/eprint/22928/ https://eprints.lincoln.ac.uk/id/eprint/22928/1/22928%20journal.pone.0040534.PDF https://doi.org/10.1371/journal.pone.0040534 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://eprints.lincoln.ac.uk/id/eprint/22928/1/22928%20journal.pone.0040534.PDF Khalife, Natasha, Glover, Vivette, Hartikainen, Anna-Liisa, Taanila, Anja, Ebeling, Hanna, Järvelin, Marjo-Riitta, Rodriguez, Alina and UNSPECIFIED (2012) Placental size Is associated with mental health in children and adolescents. PLoS ONE, 7 (7). e40534. ISSN 1932-6203 doi:10.1371/journal.pone.0040534 |
op_rights |
cc_by |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0040534 |
container_title |
PLoS ONE |
container_volume |
7 |
container_issue |
7 |
container_start_page |
e40534 |
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