Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequence...
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NATURE PUBLISHING GROUP
2017
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Online Access: | https://scholarworks.unist.ac.kr/handle/201301/21223 https://doi.org/10.1038/srep40233 http://www.nature.com/articles/srep40233 |
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ftuisanist:oai:scholarworks.unist.ac.kr:201301/21223 2023-08-20T04:06:28+02:00 Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans Nam, Kiwoong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, JeHoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon 2017-01 https://scholarworks.unist.ac.kr/handle/201301/21223 https://doi.org/10.1038/srep40233 http://www.nature.com/articles/srep40233 ?????? unknown NATURE PUBLISHING GROUP SCIENTIFIC REPORTS, v.7, pp.40233 2045-2322 https://scholarworks.unist.ac.kr/handle/201301/21223 1842 27793 2-s2.0-85009253159 000391534500001 doi:10.1038/srep40233 http://www.nature.com/articles/srep40233 ARTICLE ART 2017 ftuisanist https://doi.org/10.1038/srep40233 2023-07-28T00:35:38Z Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment. open Article in Journal/Newspaper Fin whale ScholarWorks@UNIST (Ulsan National Institute of Science and Technology) Scientific Reports 7 1 |
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ScholarWorks@UNIST (Ulsan National Institute of Science and Technology) |
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Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment. open |
format |
Article in Journal/Newspaper |
author |
Nam, Kiwoong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, JeHoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon |
spellingShingle |
Nam, Kiwoong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, JeHoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
author_facet |
Nam, Kiwoong Lee, Kyeong Won Chung, Oksung Yim, Hyung-Soon Cha, Sun-Shin Lee, Sae-Won Jun, JeHoon Cho, Yun Sung Bhak, Jong de Magalhaes, Joao Pedro Lee, Jung-Hyun Jeong, Jae-Yeon |
author_sort |
Nam, Kiwoong |
title |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_short |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_full |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_fullStr |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_full_unstemmed |
Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans |
title_sort |
analysis of the fgf gene family provides insights into aquatic adaptation in cetaceans |
publisher |
NATURE PUBLISHING GROUP |
publishDate |
2017 |
url |
https://scholarworks.unist.ac.kr/handle/201301/21223 https://doi.org/10.1038/srep40233 http://www.nature.com/articles/srep40233 |
genre |
Fin whale |
genre_facet |
Fin whale |
op_relation |
SCIENTIFIC REPORTS, v.7, pp.40233 2045-2322 https://scholarworks.unist.ac.kr/handle/201301/21223 1842 27793 2-s2.0-85009253159 000391534500001 doi:10.1038/srep40233 http://www.nature.com/articles/srep40233 |
op_doi |
https://doi.org/10.1038/srep40233 |
container_title |
Scientific Reports |
container_volume |
7 |
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1 |
_version_ |
1774717526142353408 |