Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential
Polar and subpolar ecosystems are highly vulnerable to global climate change with consequences for biodiversity and community composition. As bacteria are directly impacted by future environmental change; it is essential to have a better understanding of microbial communities in fluctuating ecosyste...
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2019
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ftuhipublicatio:oai:pure.atira.dk:publications/569be1ff-1a1f-4580-998b-2ec466dce3f2 2024-09-15T17:47:03+00:00 Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential Millán-Aguiñaga, Natalie Soldatou, Sylvia Brozio, Sarah Howe, John Hoskisson, Paul Duncan, Katherine 2019-10-08 application/pdf https://pure.uhi.ac.uk/en/publications/569be1ff-1a1f-4580-998b-2ec466dce3f2 https://doi.org/10.1099/mic.0.000845 https://pureadmin.uhi.ac.uk/ws/files/3907243/mic000845.pdf eng eng https://pure.uhi.ac.uk/en/publications/569be1ff-1a1f-4580-998b-2ec466dce3f2 info:eu-repo/semantics/openAccess Millán-Aguiñaga , N , Soldatou , S , Brozio , S , Howe , J , Hoskisson , P & Duncan , K 2019 , ' Awakening Ancient Polar Actinobacteria: Diversity, Evolution and Specialized Metabolite Potential ' , Microbiology . https://doi.org/10.1099/mic.0.000845 marine Arctic Actinobacteria Antarctic specialized metabolites and evolution article 2019 ftuhipublicatio https://doi.org/10.1099/mic.0.000845 2024-07-01T23:38:33Z Polar and subpolar ecosystems are highly vulnerable to global climate change with consequences for biodiversity and community composition. As bacteria are directly impacted by future environmental change; it is essential to have a better understanding of microbial communities in fluctuating ecosystems. Exploration of Polar environments, specifically sediments, represent an exciting opportunity to uncover bacterial and chemical diversity and link this to ecosystem and evolutionary parameters. In terms of specialized metabolite production, the bacterial order actinomycetales, within the phyla Actinobacteria are unsurpassed, producing 10000 specialized metabolites accounting for over 45% of all bioactive microbial metabolites. Culture-dependant studies of 12 sediment cores from the Antarctic and sub-Arctic generated a culture collection of 39 strains belonging to rare actinomycetales genera including Microbacterium, Rhodococcus and Pseudonocardia. This study used a combination of nanopore sequencing and molecular networking to explore the community composition, culturable bacterial diversity, evolutionary relatedness and specialized metabolite potential of these strains. Metagenomic analyses using MinION sequencencing was able to detect the phylum Actinobacteria across polar sediment cores as an average of 13% of the total bacterial reads. The resulting molecular network consisted of 1652 parent ions and the lack of known metabolite identification supports the argument that Polar bacteria are likely to produce previously unreported chemistry. Article in Journal/Newspaper Antarc* Antarctic Climate change University of the Highlands and Islands: Research Database of UHI Microbiology 165 11 1169 1180 |
institution |
Open Polar |
collection |
University of the Highlands and Islands: Research Database of UHI |
op_collection_id |
ftuhipublicatio |
language |
English |
topic |
marine Arctic Actinobacteria Antarctic specialized metabolites and evolution |
spellingShingle |
marine Arctic Actinobacteria Antarctic specialized metabolites and evolution Millán-Aguiñaga, Natalie Soldatou, Sylvia Brozio, Sarah Howe, John Hoskisson, Paul Duncan, Katherine Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
topic_facet |
marine Arctic Actinobacteria Antarctic specialized metabolites and evolution |
description |
Polar and subpolar ecosystems are highly vulnerable to global climate change with consequences for biodiversity and community composition. As bacteria are directly impacted by future environmental change; it is essential to have a better understanding of microbial communities in fluctuating ecosystems. Exploration of Polar environments, specifically sediments, represent an exciting opportunity to uncover bacterial and chemical diversity and link this to ecosystem and evolutionary parameters. In terms of specialized metabolite production, the bacterial order actinomycetales, within the phyla Actinobacteria are unsurpassed, producing 10000 specialized metabolites accounting for over 45% of all bioactive microbial metabolites. Culture-dependant studies of 12 sediment cores from the Antarctic and sub-Arctic generated a culture collection of 39 strains belonging to rare actinomycetales genera including Microbacterium, Rhodococcus and Pseudonocardia. This study used a combination of nanopore sequencing and molecular networking to explore the community composition, culturable bacterial diversity, evolutionary relatedness and specialized metabolite potential of these strains. Metagenomic analyses using MinION sequencencing was able to detect the phylum Actinobacteria across polar sediment cores as an average of 13% of the total bacterial reads. The resulting molecular network consisted of 1652 parent ions and the lack of known metabolite identification supports the argument that Polar bacteria are likely to produce previously unreported chemistry. |
format |
Article in Journal/Newspaper |
author |
Millán-Aguiñaga, Natalie Soldatou, Sylvia Brozio, Sarah Howe, John Hoskisson, Paul Duncan, Katherine |
author_facet |
Millán-Aguiñaga, Natalie Soldatou, Sylvia Brozio, Sarah Howe, John Hoskisson, Paul Duncan, Katherine |
author_sort |
Millán-Aguiñaga, Natalie |
title |
Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
title_short |
Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
title_full |
Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
title_fullStr |
Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
title_full_unstemmed |
Awakening Ancient Polar Actinobacteria::Diversity, Evolution and Specialized Metabolite Potential |
title_sort |
awakening ancient polar actinobacteria::diversity, evolution and specialized metabolite potential |
publishDate |
2019 |
url |
https://pure.uhi.ac.uk/en/publications/569be1ff-1a1f-4580-998b-2ec466dce3f2 https://doi.org/10.1099/mic.0.000845 https://pureadmin.uhi.ac.uk/ws/files/3907243/mic000845.pdf |
genre |
Antarc* Antarctic Climate change |
genre_facet |
Antarc* Antarctic Climate change |
op_source |
Millán-Aguiñaga , N , Soldatou , S , Brozio , S , Howe , J , Hoskisson , P & Duncan , K 2019 , ' Awakening Ancient Polar Actinobacteria: Diversity, Evolution and Specialized Metabolite Potential ' , Microbiology . https://doi.org/10.1099/mic.0.000845 |
op_relation |
https://pure.uhi.ac.uk/en/publications/569be1ff-1a1f-4580-998b-2ec466dce3f2 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1099/mic.0.000845 |
container_title |
Microbiology |
container_volume |
165 |
container_issue |
11 |
container_start_page |
1169 |
op_container_end_page |
1180 |
_version_ |
1810495587106160640 |