Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena)
A 7-year-old female harbour porpoise (Phocoena phocoena), born and held in captivity, suffered from reduced consciousness, imprecise and circling swimming movements and long phases of immobility over a period of 3 weeks. The animal died during treatment in a Danish open sea facility. Pathological ex...
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ftuglasgow:oai:eprints.gla.ac.uk:266285 2023-05-15T16:33:18+02:00 Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) Herder, V. van de Velde, N. Højer Kristensen, J. van Elk, C. Peters, M. Kilwinski, J. Schares, G. Siebert, U. Wohlsein, P. 2015-11 http://eprints.gla.ac.uk/266285/ unknown Elsevier Herder, V. <http://eprints.gla.ac.uk/view/author/44984.html> , van de Velde, N., Højer Kristensen, J., van Elk, C., Peters, M., Kilwinski, J., Schares, G., Siebert, U. and Wohlsein, P. (2015) Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena). Journal of Comparative Pathology <http://eprints.gla.ac.uk/view/journal_volume/Journal_of_Comparative_Pathology.html>, 153(4), pp. 357-362. (doi:10.1016/j.jcpa.2015.08.004 <https://dx.doi.org/10.1016/j.jcpa.2015.08.004>) (PMID:26381675) Articles PeerReviewed 2015 ftuglasgow https://doi.org/10.1016/j.jcpa.2015.08.004 2022-08-04T22:20:13Z A 7-year-old female harbour porpoise (Phocoena phocoena), born and held in captivity, suffered from reduced consciousness, imprecise and circling swimming movements and long phases of immobility over a period of 3 weeks. The animal died during treatment in a Danish open sea facility. Pathological examination revealed multifocal pyogranulomatous to necrotizing meningoencephalomyelitis, ganglioneuritis, plexus chorioiditis, myocarditis, hepatitis and adrenalitis with few intralesional protozoal tachyzoites and bradyzoites within cysts. Immunohistochemistry was positive for Toxoplasma gondii antigen within the lesions. Using polymerase chain reaction (PCR), the presence of T. gondii-specific genome fragments was confirmed. A multilocus PCR-restriction fragment length polymorphism analysis using nine unlinked marker regions (nSAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 and Apico) resulted in the identification of T. gondii type II (variant Apico Type I), which is the T. gondii genotype dominating in Germany. This is the first description of disseminated fatal toxoplasmosis in a captive harbour porpoise that lived in an open sea basin. Surface water contaminated with toxoplasma oocysts is regarded as the most likely source of infection. Article in Journal/Newspaper Harbour porpoise Phocoena phocoena University of Glasgow: Enlighten - Publications Journal of Comparative Pathology 153 4 357 362 |
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University of Glasgow: Enlighten - Publications |
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ftuglasgow |
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description |
A 7-year-old female harbour porpoise (Phocoena phocoena), born and held in captivity, suffered from reduced consciousness, imprecise and circling swimming movements and long phases of immobility over a period of 3 weeks. The animal died during treatment in a Danish open sea facility. Pathological examination revealed multifocal pyogranulomatous to necrotizing meningoencephalomyelitis, ganglioneuritis, plexus chorioiditis, myocarditis, hepatitis and adrenalitis with few intralesional protozoal tachyzoites and bradyzoites within cysts. Immunohistochemistry was positive for Toxoplasma gondii antigen within the lesions. Using polymerase chain reaction (PCR), the presence of T. gondii-specific genome fragments was confirmed. A multilocus PCR-restriction fragment length polymorphism analysis using nine unlinked marker regions (nSAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 and Apico) resulted in the identification of T. gondii type II (variant Apico Type I), which is the T. gondii genotype dominating in Germany. This is the first description of disseminated fatal toxoplasmosis in a captive harbour porpoise that lived in an open sea basin. Surface water contaminated with toxoplasma oocysts is regarded as the most likely source of infection. |
format |
Article in Journal/Newspaper |
author |
Herder, V. van de Velde, N. Højer Kristensen, J. van Elk, C. Peters, M. Kilwinski, J. Schares, G. Siebert, U. Wohlsein, P. |
spellingShingle |
Herder, V. van de Velde, N. Højer Kristensen, J. van Elk, C. Peters, M. Kilwinski, J. Schares, G. Siebert, U. Wohlsein, P. Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
author_facet |
Herder, V. van de Velde, N. Højer Kristensen, J. van Elk, C. Peters, M. Kilwinski, J. Schares, G. Siebert, U. Wohlsein, P. |
author_sort |
Herder, V. |
title |
Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
title_short |
Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
title_full |
Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
title_fullStr |
Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
title_full_unstemmed |
Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena) |
title_sort |
fatal disseminated toxoplasma gondii infection in a captive harbour porpoise (phocoena phocoena) |
publisher |
Elsevier |
publishDate |
2015 |
url |
http://eprints.gla.ac.uk/266285/ |
genre |
Harbour porpoise Phocoena phocoena |
genre_facet |
Harbour porpoise Phocoena phocoena |
op_relation |
Herder, V. <http://eprints.gla.ac.uk/view/author/44984.html> , van de Velde, N., Højer Kristensen, J., van Elk, C., Peters, M., Kilwinski, J., Schares, G., Siebert, U. and Wohlsein, P. (2015) Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena). Journal of Comparative Pathology <http://eprints.gla.ac.uk/view/journal_volume/Journal_of_Comparative_Pathology.html>, 153(4), pp. 357-362. (doi:10.1016/j.jcpa.2015.08.004 <https://dx.doi.org/10.1016/j.jcpa.2015.08.004>) (PMID:26381675) |
op_doi |
https://doi.org/10.1016/j.jcpa.2015.08.004 |
container_title |
Journal of Comparative Pathology |
container_volume |
153 |
container_issue |
4 |
container_start_page |
357 |
op_container_end_page |
362 |
_version_ |
1766022995544899584 |