Long-lived animals with negligible senescence: clues for ageing research
Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rap...
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Online Access: | http://eprints.gla.ac.uk/193157/ http://eprints.gla.ac.uk/193157/7/193157.pdf |
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ftuglasgow:oai:eprints.gla.ac.uk:193157 2023-05-15T16:28:34+02:00 Long-lived animals with negligible senescence: clues for ageing research Stenvinkel, Peter Shiels, Paul G. 2019-08 text http://eprints.gla.ac.uk/193157/ http://eprints.gla.ac.uk/193157/7/193157.pdf en eng Portland Press http://eprints.gla.ac.uk/193157/7/193157.pdf Stenvinkel, P. and Shiels, P. G. <http://eprints.gla.ac.uk/view/author/10327.html> (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions <http://eprints.gla.ac.uk/view/journal_volume/Biochemical_Society_Transactions.html>, 47(4), pp. 1157-1164. (doi:10.1042/BST20190105 <http://dx.doi.org/10.1042/BST20190105>) (PMID:31366472) Articles PeerReviewed 2019 ftuglasgow https://doi.org/10.1042/BST20190105 2020-08-13T22:10:02Z Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases. Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span. Article in Journal/Newspaper Greenland Ocean quahog University of Glasgow: Enlighten - Publications Greenland Biochemical Society Transactions 47 4 1157 1164 |
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Open Polar |
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University of Glasgow: Enlighten - Publications |
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ftuglasgow |
language |
English |
description |
Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases. Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span. |
format |
Article in Journal/Newspaper |
author |
Stenvinkel, Peter Shiels, Paul G. |
spellingShingle |
Stenvinkel, Peter Shiels, Paul G. Long-lived animals with negligible senescence: clues for ageing research |
author_facet |
Stenvinkel, Peter Shiels, Paul G. |
author_sort |
Stenvinkel, Peter |
title |
Long-lived animals with negligible senescence: clues for ageing research |
title_short |
Long-lived animals with negligible senescence: clues for ageing research |
title_full |
Long-lived animals with negligible senescence: clues for ageing research |
title_fullStr |
Long-lived animals with negligible senescence: clues for ageing research |
title_full_unstemmed |
Long-lived animals with negligible senescence: clues for ageing research |
title_sort |
long-lived animals with negligible senescence: clues for ageing research |
publisher |
Portland Press |
publishDate |
2019 |
url |
http://eprints.gla.ac.uk/193157/ http://eprints.gla.ac.uk/193157/7/193157.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland Ocean quahog |
genre_facet |
Greenland Ocean quahog |
op_relation |
http://eprints.gla.ac.uk/193157/7/193157.pdf Stenvinkel, P. and Shiels, P. G. <http://eprints.gla.ac.uk/view/author/10327.html> (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions <http://eprints.gla.ac.uk/view/journal_volume/Biochemical_Society_Transactions.html>, 47(4), pp. 1157-1164. (doi:10.1042/BST20190105 <http://dx.doi.org/10.1042/BST20190105>) (PMID:31366472) |
op_doi |
https://doi.org/10.1042/BST20190105 |
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Biochemical Society Transactions |
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47 |
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4 |
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1157 |
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1164 |
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1766018221776830464 |