An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source
Background: Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation. Case presentation: We describe a case of E. rhusiopathiae prostheti...
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ftuglasgow:oai:eprints.gla.ac.uk:182992 2023-05-15T14:27:35+02:00 An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source Groeschel, Michael Forde, Taya Turvey, Shannon Joffe, A. Mark Hui, Catherine Naidu, Prenilla Mavrot, Fabien Kutz, Susan Singh, Ameeta E. 2019-03-25 text https://eprints.gla.ac.uk/182992/ https://eprints.gla.ac.uk/182992/1/182992.pdf en eng BioMed Central https://eprints.gla.ac.uk/182992/1/182992.pdf Groeschel, M., Forde, T. <http://eprints.gla.ac.uk/view/author/31219.html> , Turvey, S., Joffe, A. M., Hui, C., Naidu, P., Mavrot, F., Kutz, S. and Singh, A. E. (2019) An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source. BMC Infectious Diseases <https://eprints.gla.ac.uk/view/journal_volume/BMC_Infectious_Diseases.html>, 19, 282. (doi:10.1186/s12879-019-3913-7 <https://doi.org/10.1186/s12879-019-3913-7>) (PMID:30909869) (PMCID:PMC6434803) cc_by_4 CC-BY Articles PeerReviewed 2019 ftuglasgow https://doi.org/10.1186/s12879-019-3913-7 2022-09-22T22:15:02Z Background: Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation. Case presentation: We describe a case of E. rhusiopathiae prosthetic joint infection in a woman with a history of exposure to wild animals in the Canadian Arctic. Patient management involved a 1-stage surgical revision exchange with an antibiotic impregnated cement spacer and 6 weeks of intravenous penicillin G followed by 6 weeks of oral amoxicillin. Ten previously reported cases of E. rhusiopathiae joint infection are reviewed. Recent increases in mortality due to infection with this organism among host animal populations in the Canadian Arctic have generated concern regarding a potential increase in human infections. However, whole genome sequencing (WGS) of the organism was unable to identify a zoonotic origin for this case. Conclusions: Consideration should be given to E. rhusiopathiae as a cause of joint infections if the appropriate epidemiologic and host risk factors exist. Expanded use of WGS in other potential animal hosts and environmental sources may provide important epidemiologic information in determining the source of human infections. Article in Journal/Newspaper Arctic Arctic University of Glasgow: Enlighten - Publications Arctic BMC Infectious Diseases 19 1 |
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Open Polar |
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University of Glasgow: Enlighten - Publications |
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ftuglasgow |
language |
English |
description |
Background: Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation. Case presentation: We describe a case of E. rhusiopathiae prosthetic joint infection in a woman with a history of exposure to wild animals in the Canadian Arctic. Patient management involved a 1-stage surgical revision exchange with an antibiotic impregnated cement spacer and 6 weeks of intravenous penicillin G followed by 6 weeks of oral amoxicillin. Ten previously reported cases of E. rhusiopathiae joint infection are reviewed. Recent increases in mortality due to infection with this organism among host animal populations in the Canadian Arctic have generated concern regarding a potential increase in human infections. However, whole genome sequencing (WGS) of the organism was unable to identify a zoonotic origin for this case. Conclusions: Consideration should be given to E. rhusiopathiae as a cause of joint infections if the appropriate epidemiologic and host risk factors exist. Expanded use of WGS in other potential animal hosts and environmental sources may provide important epidemiologic information in determining the source of human infections. |
format |
Article in Journal/Newspaper |
author |
Groeschel, Michael Forde, Taya Turvey, Shannon Joffe, A. Mark Hui, Catherine Naidu, Prenilla Mavrot, Fabien Kutz, Susan Singh, Ameeta E. |
spellingShingle |
Groeschel, Michael Forde, Taya Turvey, Shannon Joffe, A. Mark Hui, Catherine Naidu, Prenilla Mavrot, Fabien Kutz, Susan Singh, Ameeta E. An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
author_facet |
Groeschel, Michael Forde, Taya Turvey, Shannon Joffe, A. Mark Hui, Catherine Naidu, Prenilla Mavrot, Fabien Kutz, Susan Singh, Ameeta E. |
author_sort |
Groeschel, Michael |
title |
An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
title_short |
An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
title_full |
An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
title_fullStr |
An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
title_full_unstemmed |
An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source |
title_sort |
unusual case of erysipelothrix rhusiopathiae prosthetic joint infection from the canadian arctic: whole genome sequencing unable to identify a zoonotic source |
publisher |
BioMed Central |
publishDate |
2019 |
url |
https://eprints.gla.ac.uk/182992/ https://eprints.gla.ac.uk/182992/1/182992.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic |
genre_facet |
Arctic Arctic |
op_relation |
https://eprints.gla.ac.uk/182992/1/182992.pdf Groeschel, M., Forde, T. <http://eprints.gla.ac.uk/view/author/31219.html> , Turvey, S., Joffe, A. M., Hui, C., Naidu, P., Mavrot, F., Kutz, S. and Singh, A. E. (2019) An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source. BMC Infectious Diseases <https://eprints.gla.ac.uk/view/journal_volume/BMC_Infectious_Diseases.html>, 19, 282. (doi:10.1186/s12879-019-3913-7 <https://doi.org/10.1186/s12879-019-3913-7>) (PMID:30909869) (PMCID:PMC6434803) |
op_rights |
cc_by_4 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12879-019-3913-7 |
container_title |
BMC Infectious Diseases |
container_volume |
19 |
container_issue |
1 |
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1766301391704293376 |