Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology
Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of patho...
Published in: | European Journal of Heart Failure |
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Online Access: | http://eprints.gla.ac.uk/174967/ http://eprints.gla.ac.uk/174967/7/174967.pdf |
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ftuglasgow:oai:eprints.gla.ac.uk:174967 2023-05-15T18:15:18+02:00 Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology de Boer, Rudolf A. De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G. Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R. Lipson, Kenneth McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G. Lyon, Alexander R. Pollesello, Piero Prasad, Sanjay K. Tocchetti, Carlo G. Mayr, Mayr Sluijter, Joost P.G. Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L. Maack, Christoph Heymans, Stephane 2019-03 text http://eprints.gla.ac.uk/174967/ http://eprints.gla.ac.uk/174967/7/174967.pdf en eng Wiley http://eprints.gla.ac.uk/174967/7/174967.pdf de Boer, R. A. et al. (2019) Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. European Journal of Heart Failure <http://eprints.gla.ac.uk/view/journal_volume/European_Journal_of_Heart_Failure.html>, 21(3), pp. 272-285. (doi:10.1002/ejhf.1406 <http://dx.doi.org/10.1002/ejhf.1406>) (PMID:30714667) (PMCID:PMC6607480) cc_by_nc_4 CC-BY-NC Articles PeerReviewed 2019 ftuglasgow https://doi.org/10.1002/ejhf.1406 2020-05-28T22:24:48Z Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. The Translational Research Committee of the Heart Failure Association discussed several aspects of fibrosis in their workshop. Early insidious perturbations such as subclinical hypertension or inflammation may trigger first fibrotic events, while more dramatic triggers such as myocardial infarction and myocarditis give rise to full blown scar formation and ongoing fibrosis in diseased hearts. Aging itself is also associated with a cardiac phenotype that includes fibrosis. Fibrosis is an extremely heterogeneous phenomenon, as several stages of the fibrotic process exist, each with different fibrosis subtypes and a different composition of various cells and proteins — resulting in a very complex pathophysiology. As a result, detection of fibrosis, e.g. using current cardiac imaging modalities or plasma biomarkers, will detect only specific subforms of fibrosis, but cannot capture all aspects of the complex fibrotic process. Furthermore, several anti‐fibrotic therapies are under investigation, but such therapies generally target aspecific aspects of the fibrotic process and suffer from a lack of precision. This review discusses the mechanisms and the caveats and proposes a roadmap for future research. Article in Journal/Newspaper SCAR University of Glasgow: Enlighten - Publications European Journal of Heart Failure 21 3 272 285 |
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University of Glasgow: Enlighten - Publications |
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ftuglasgow |
language |
English |
description |
Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. The Translational Research Committee of the Heart Failure Association discussed several aspects of fibrosis in their workshop. Early insidious perturbations such as subclinical hypertension or inflammation may trigger first fibrotic events, while more dramatic triggers such as myocardial infarction and myocarditis give rise to full blown scar formation and ongoing fibrosis in diseased hearts. Aging itself is also associated with a cardiac phenotype that includes fibrosis. Fibrosis is an extremely heterogeneous phenomenon, as several stages of the fibrotic process exist, each with different fibrosis subtypes and a different composition of various cells and proteins — resulting in a very complex pathophysiology. As a result, detection of fibrosis, e.g. using current cardiac imaging modalities or plasma biomarkers, will detect only specific subforms of fibrosis, but cannot capture all aspects of the complex fibrotic process. Furthermore, several anti‐fibrotic therapies are under investigation, but such therapies generally target aspecific aspects of the fibrotic process and suffer from a lack of precision. This review discusses the mechanisms and the caveats and proposes a roadmap for future research. |
format |
Article in Journal/Newspaper |
author |
de Boer, Rudolf A. De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G. Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R. Lipson, Kenneth McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G. Lyon, Alexander R. Pollesello, Piero Prasad, Sanjay K. Tocchetti, Carlo G. Mayr, Mayr Sluijter, Joost P.G. Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L. Maack, Christoph Heymans, Stephane |
spellingShingle |
de Boer, Rudolf A. De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G. Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R. Lipson, Kenneth McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G. Lyon, Alexander R. Pollesello, Piero Prasad, Sanjay K. Tocchetti, Carlo G. Mayr, Mayr Sluijter, Joost P.G. Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L. Maack, Christoph Heymans, Stephane Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
author_facet |
de Boer, Rudolf A. De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G. Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R. Lipson, Kenneth McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G. Lyon, Alexander R. Pollesello, Piero Prasad, Sanjay K. Tocchetti, Carlo G. Mayr, Mayr Sluijter, Joost P.G. Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L. Maack, Christoph Heymans, Stephane |
author_sort |
de Boer, Rudolf A. |
title |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_short |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_full |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_fullStr |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_full_unstemmed |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_sort |
towards better definition, quantification and treatment of fibrosis in heart failure. a scientific roadmap by the committee of translational research of the heart failure association (hfa) of the european society of cardiology |
publisher |
Wiley |
publishDate |
2019 |
url |
http://eprints.gla.ac.uk/174967/ http://eprints.gla.ac.uk/174967/7/174967.pdf |
genre |
SCAR |
genre_facet |
SCAR |
op_relation |
http://eprints.gla.ac.uk/174967/7/174967.pdf de Boer, R. A. et al. (2019) Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. European Journal of Heart Failure <http://eprints.gla.ac.uk/view/journal_volume/European_Journal_of_Heart_Failure.html>, 21(3), pp. 272-285. (doi:10.1002/ejhf.1406 <http://dx.doi.org/10.1002/ejhf.1406>) (PMID:30714667) (PMCID:PMC6607480) |
op_rights |
cc_by_nc_4 |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1002/ejhf.1406 |
container_title |
European Journal of Heart Failure |
container_volume |
21 |
container_issue |
3 |
container_start_page |
272 |
op_container_end_page |
285 |
_version_ |
1766188398464204800 |