Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya
Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by...
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ftuglasgow:oai:eprints.gla.ac.uk:103860 2023-05-15T18:05:22+02:00 Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya Halliday, Jo E.B. Knobel, Darryn L. Agwanda, Bernard F. Bai, Ying Breiman, Robert F. Cleaveland, Sarah Njenga, M.Kariuki Kosoy, Michael 2015-03 text https://eprints.gla.ac.uk/103860/ https://eprints.gla.ac.uk/103860/1/103860.pdf en eng Public Library of Science https://eprints.gla.ac.uk/103860/1/103860.pdf Halliday, J. E.B. <http://eprints.gla.ac.uk/view/author/7735.html> , Knobel, D. L. <http://eprints.gla.ac.uk/view/author/4446.html> , Agwanda, B. F., Bai, Y., Breiman, R. F., Cleaveland, S. <http://eprints.gla.ac.uk/view/author/12137.html> , Njenga, M.K. and Kosoy, M. (2015) Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. PLoS Neglected Tropical Diseases <https://eprints.gla.ac.uk/view/journal_volume/PLoS_Neglected_Tropical_Diseases.html>, 9(3), e0003608. (doi:10.1371/journal.pntd.0003608 <https://doi.org/10.1371/journal.pntd.0003608>) (PMID:25781015) (PMCID:PMC4362764) cc_public_domain PDM Articles PeerReviewed 2015 ftuglasgow https://doi.org/10.1371/journal.pntd.0003608 2023-01-12T23:08:53Z Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted. Article in Journal/Newspaper Rattus rattus University of Glasgow: Enlighten - Publications PLOS Neglected Tropical Diseases 9 3 e0003608 |
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University of Glasgow: Enlighten - Publications |
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English |
description |
Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted. |
format |
Article in Journal/Newspaper |
author |
Halliday, Jo E.B. Knobel, Darryn L. Agwanda, Bernard F. Bai, Ying Breiman, Robert F. Cleaveland, Sarah Njenga, M.Kariuki Kosoy, Michael |
spellingShingle |
Halliday, Jo E.B. Knobel, Darryn L. Agwanda, Bernard F. Bai, Ying Breiman, Robert F. Cleaveland, Sarah Njenga, M.Kariuki Kosoy, Michael Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
author_facet |
Halliday, Jo E.B. Knobel, Darryn L. Agwanda, Bernard F. Bai, Ying Breiman, Robert F. Cleaveland, Sarah Njenga, M.Kariuki Kosoy, Michael |
author_sort |
Halliday, Jo E.B. |
title |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
title_short |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
title_full |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
title_fullStr |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
title_full_unstemmed |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya |
title_sort |
prevalence and diversity of small mammal-associated bartonella species in rural and urban kenya |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
https://eprints.gla.ac.uk/103860/ https://eprints.gla.ac.uk/103860/1/103860.pdf |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
https://eprints.gla.ac.uk/103860/1/103860.pdf Halliday, J. E.B. <http://eprints.gla.ac.uk/view/author/7735.html> , Knobel, D. L. <http://eprints.gla.ac.uk/view/author/4446.html> , Agwanda, B. F., Bai, Y., Breiman, R. F., Cleaveland, S. <http://eprints.gla.ac.uk/view/author/12137.html> , Njenga, M.K. and Kosoy, M. (2015) Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. PLoS Neglected Tropical Diseases <https://eprints.gla.ac.uk/view/journal_volume/PLoS_Neglected_Tropical_Diseases.html>, 9(3), e0003608. (doi:10.1371/journal.pntd.0003608 <https://doi.org/10.1371/journal.pntd.0003608>) (PMID:25781015) (PMCID:PMC4362764) |
op_rights |
cc_public_domain |
op_rightsnorm |
PDM |
op_doi |
https://doi.org/10.1371/journal.pntd.0003608 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
3 |
container_start_page |
e0003608 |
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1766176845594624000 |