Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus
The ontogeny of the endocrine pancreas of a teleost, the turbot (Scophthalmus maximus), was investigated by the use of double immunofluorescence. Clustered insulin (INS)-immunoreactive (IR) cells were observed on the first day after hatching. During the following days, the islet largely increased in...
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1995
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ftufz:oai:ufz.de:27621 2023-12-10T09:53:25+01:00 Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus Berwert, L. Segner, H. Reinecke, M. 1995 application/pdf https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=27621 https://doi.org/10.1016/0196-9781(94)00161-X en eng Elsevier Peptides 16 (1);; 113 - 122 https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=27621 https://dx.doi.org/10.1016/0196-9781(94)00161-X info:eu-repo/semantics/closedAccess ISSN: 0196-9781 Endocrine pancreas Ontogeny Insulin Glucagon Somatostatin Pancreatic polypeptide Insulin-like growth factor 1 Coexistence Scophthalmus maximus Teleosts info:eu-repo/semantics/article https://purl.org/dc/dcmitype/Text 1995 ftufz https://doi.org/10.1016/0196-9781(94)00161-X 2023-11-12T23:37:51Z The ontogeny of the endocrine pancreas of a teleost, the turbot (Scophthalmus maximus), was investigated by the use of double immunofluorescence. Clustered insulin (INS)-immunoreactive (IR) cells were observed on the first day after hatching. During the following days, the islet largely increased in size and some smaller islets appeared. All islets consisted only of INS-IR cells. Between day 5 (onset of exogenous feeding) and 7, somatostatin (SOM) and glucagon (GLUC) cells appeared. In the large (principal) islet, the SOM-IR cells intermingled with the INS-IR cells. In the secondary islets, they occurred at the periphery. The GLUC-IR cells were located at the periphery in all islets. Subsequently, two-four additional small principal islets appeared. At day 11, pancreatic polypeptide (PP)-IR cells were present in principal islets and secondary islets. Starting with day 11, in all islets, insulin-like growth factor 1 (IGF-1) immunoreactivity was localized in numerous PP-IR cells and GLUC-IR and some SOM-IR cells. It also occurred in enteroendocrine cells that seemed to contain none of the classical islet hormones. The early appearance of INS correlates with its key role in the regulation of fish protein and lipid metabolism. Islet-derived IGF-1 might inhibit the regulation of INS secretion in a paracrine manner and may be highly involved in growth-promoting processes. Article in Journal/Newspaper Scophthalmus maximus Turbot UFZ - Publication Index (Helmholtz-Centre for Environmental Research) Peptides 16 1 113 122 |
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collection |
UFZ - Publication Index (Helmholtz-Centre for Environmental Research) |
op_collection_id |
ftufz |
language |
English |
topic |
Endocrine pancreas Ontogeny Insulin Glucagon Somatostatin Pancreatic polypeptide Insulin-like growth factor 1 Coexistence Scophthalmus maximus Teleosts |
spellingShingle |
Endocrine pancreas Ontogeny Insulin Glucagon Somatostatin Pancreatic polypeptide Insulin-like growth factor 1 Coexistence Scophthalmus maximus Teleosts Berwert, L. Segner, H. Reinecke, M. Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
topic_facet |
Endocrine pancreas Ontogeny Insulin Glucagon Somatostatin Pancreatic polypeptide Insulin-like growth factor 1 Coexistence Scophthalmus maximus Teleosts |
description |
The ontogeny of the endocrine pancreas of a teleost, the turbot (Scophthalmus maximus), was investigated by the use of double immunofluorescence. Clustered insulin (INS)-immunoreactive (IR) cells were observed on the first day after hatching. During the following days, the islet largely increased in size and some smaller islets appeared. All islets consisted only of INS-IR cells. Between day 5 (onset of exogenous feeding) and 7, somatostatin (SOM) and glucagon (GLUC) cells appeared. In the large (principal) islet, the SOM-IR cells intermingled with the INS-IR cells. In the secondary islets, they occurred at the periphery. The GLUC-IR cells were located at the periphery in all islets. Subsequently, two-four additional small principal islets appeared. At day 11, pancreatic polypeptide (PP)-IR cells were present in principal islets and secondary islets. Starting with day 11, in all islets, insulin-like growth factor 1 (IGF-1) immunoreactivity was localized in numerous PP-IR cells and GLUC-IR and some SOM-IR cells. It also occurred in enteroendocrine cells that seemed to contain none of the classical islet hormones. The early appearance of INS correlates with its key role in the regulation of fish protein and lipid metabolism. Islet-derived IGF-1 might inhibit the regulation of INS secretion in a paracrine manner and may be highly involved in growth-promoting processes. |
format |
Article in Journal/Newspaper |
author |
Berwert, L. Segner, H. Reinecke, M. |
author_facet |
Berwert, L. Segner, H. Reinecke, M. |
author_sort |
Berwert, L. |
title |
Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
title_short |
Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
title_full |
Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
title_fullStr |
Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
title_full_unstemmed |
Ontogeny of IGF-1 and the classical islet hormones in the turbot, Scophthalmus maximus |
title_sort |
ontogeny of igf-1 and the classical islet hormones in the turbot, scophthalmus maximus |
publisher |
Elsevier |
publishDate |
1995 |
url |
https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=27621 https://doi.org/10.1016/0196-9781(94)00161-X |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
ISSN: 0196-9781 |
op_relation |
https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=27621 https://dx.doi.org/10.1016/0196-9781(94)00161-X |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/0196-9781(94)00161-X |
container_title |
Peptides |
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16 |
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1 |
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113 |
op_container_end_page |
122 |
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1784900317043752960 |