Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia.
OBJECTIVE: Previous research has consistently implicated genetic factors in the pathogenesis of schizophrenia. It has been hypothesized that an abnormality in glutamatergic function is of etiologic importance in schizophrenia, and therefore the glutamate receptor family of genes are potential suscep...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:88976 2023-05-15T16:49:54+02:00 Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Petursson, H Barnard, EA Gurling, HM 1996-12 http://discovery.ucl.ac.uk/88976/ unknown Am J Psychiatry , 153 (12) pp. 1634-1636. (1996) Alleles England Family Genetic Linkage Humans Iceland Lod Score Pedigree Polymorphism Genetic Receptors Glutamate Schizophrenia Trinucleotide Repeats Article 1996 ftucl 2016-01-15T02:19:07Z OBJECTIVE: Previous research has consistently implicated genetic factors in the pathogenesis of schizophrenia. It has been hypothesized that an abnormality in glutamatergic function is of etiologic importance in schizophrenia, and therefore the glutamate receptor family of genes are potential susceptibility loci for schizophrenia. To test this hypothesis the authors sought to detect linkage between the GluR6 glutamate receptor gene and schizophrenia. METHOD: Twenty-three English and Icelandic families containing multiple cases of schizophrenia were genotyped with a microsatellite trinucleotide repeat polymorphism localized at the GluR6 glutamate receptor locus. Lod scores, model-free linkage analysis, and extended relative pair analysis were used to test for linkage. RESULTS: No statistically significant evidence of linkage between GluR6 and schizophrenia was found. CONCLUSIONS: The results do not support the hypothesis that GluR6 allelic variants provide a major gene contribution to the etiology of schizophrenia in a large proportion of these pedigrees. Article in Journal/Newspaper Iceland University College London: UCL Discovery |
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University College London: UCL Discovery |
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topic |
Alleles England Family Genetic Linkage Humans Iceland Lod Score Pedigree Polymorphism Genetic Receptors Glutamate Schizophrenia Trinucleotide Repeats |
spellingShingle |
Alleles England Family Genetic Linkage Humans Iceland Lod Score Pedigree Polymorphism Genetic Receptors Glutamate Schizophrenia Trinucleotide Repeats Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Petursson, H Barnard, EA Gurling, HM Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
topic_facet |
Alleles England Family Genetic Linkage Humans Iceland Lod Score Pedigree Polymorphism Genetic Receptors Glutamate Schizophrenia Trinucleotide Repeats |
description |
OBJECTIVE: Previous research has consistently implicated genetic factors in the pathogenesis of schizophrenia. It has been hypothesized that an abnormality in glutamatergic function is of etiologic importance in schizophrenia, and therefore the glutamate receptor family of genes are potential susceptibility loci for schizophrenia. To test this hypothesis the authors sought to detect linkage between the GluR6 glutamate receptor gene and schizophrenia. METHOD: Twenty-three English and Icelandic families containing multiple cases of schizophrenia were genotyped with a microsatellite trinucleotide repeat polymorphism localized at the GluR6 glutamate receptor locus. Lod scores, model-free linkage analysis, and extended relative pair analysis were used to test for linkage. RESULTS: No statistically significant evidence of linkage between GluR6 and schizophrenia was found. CONCLUSIONS: The results do not support the hypothesis that GluR6 allelic variants provide a major gene contribution to the etiology of schizophrenia in a large proportion of these pedigrees. |
format |
Article in Journal/Newspaper |
author |
Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Petursson, H Barnard, EA Gurling, HM |
author_facet |
Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Petursson, H Barnard, EA Gurling, HM |
author_sort |
Chen, AC |
title |
Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
title_short |
Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
title_full |
Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
title_fullStr |
Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
title_full_unstemmed |
Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia. |
title_sort |
lack of evidence for close linkage of the glutamate glur6 receptor gene with schizophrenia. |
publishDate |
1996 |
url |
http://discovery.ucl.ac.uk/88976/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Am J Psychiatry , 153 (12) pp. 1634-1636. (1996) |
_version_ |
1766040078997520384 |