Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.
An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/a...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:88974 2023-05-15T16:50:12+02:00 Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Barnard, EA Petursson, H Gurling, HM 1997-02-21 http://discovery.ucl.ac.uk/88974/ unknown Am J Med Genet , 74 (1) pp. 50-52. (1997) Alleles Amino Acid Transport System X-AG Carrier Proteins England Female Genetic Linkage Genetic Markers Genotype Glycoproteins Humans Iceland Lod Score Male Pedigree Polymerase Chain Reaction Recombination Genetic Schizophrenia Software Article 1997 ftucl 2016-01-15T02:19:07Z An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence of linkage between SLC1A5 and schizophrenia was found. Our results do not support the hypothesis that SLC1A5 gene mutations or allelic variants provide a major gene contribution to the etiology of schizophrenia. However, because of the likelihood of heterogeneity of linkage in schizophrenia, there is a case for testing other pedigrees for linkage to the SLC1A5 locus. The SLC1A5 locus is one of a complex family of genes encoding neutral amino acid transporter proteins and the genetic relation between these other loci and schizophrenia has not yet been established. Article in Journal/Newspaper Iceland University College London: UCL Discovery |
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University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
unknown |
topic |
Alleles Amino Acid Transport System X-AG Carrier Proteins England Female Genetic Linkage Genetic Markers Genotype Glycoproteins Humans Iceland Lod Score Male Pedigree Polymerase Chain Reaction Recombination Genetic Schizophrenia Software |
spellingShingle |
Alleles Amino Acid Transport System X-AG Carrier Proteins England Female Genetic Linkage Genetic Markers Genotype Glycoproteins Humans Iceland Lod Score Male Pedigree Polymerase Chain Reaction Recombination Genetic Schizophrenia Software Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Barnard, EA Petursson, H Gurling, HM Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
topic_facet |
Alleles Amino Acid Transport System X-AG Carrier Proteins England Female Genetic Linkage Genetic Markers Genotype Glycoproteins Humans Iceland Lod Score Male Pedigree Polymerase Chain Reaction Recombination Genetic Schizophrenia Software |
description |
An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence of linkage between SLC1A5 and schizophrenia was found. Our results do not support the hypothesis that SLC1A5 gene mutations or allelic variants provide a major gene contribution to the etiology of schizophrenia. However, because of the likelihood of heterogeneity of linkage in schizophrenia, there is a case for testing other pedigrees for linkage to the SLC1A5 locus. The SLC1A5 locus is one of a complex family of genes encoding neutral amino acid transporter proteins and the genetic relation between these other loci and schizophrenia has not yet been established. |
format |
Article in Journal/Newspaper |
author |
Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Barnard, EA Petursson, H Gurling, HM |
author_facet |
Chen, AC Kalsi, G Brynjolfsson, J Sigmundsson, T Curtis, D Butler, R Read, T Murphy, P Barnard, EA Petursson, H Gurling, HM |
author_sort |
Chen, AC |
title |
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
title_short |
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
title_full |
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
title_fullStr |
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
title_full_unstemmed |
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5. |
title_sort |
exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, slc1a5. |
publishDate |
1997 |
url |
http://discovery.ucl.ac.uk/88974/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Am J Med Genet , 74 (1) pp. 50-52. (1997) |
_version_ |
1766040369981554688 |