The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia.
Marfan syndrome (MS) is a rare autosomal dominant disorder of connective tissue with manifestations in the cardiovascular, ocular and skeletal systems. Genetic linkage analysis with random probes has mapped the MS locus to 15q21.1. There have been several reports of Marfan syndrome co-segregating wi...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:88957 2023-05-15T16:49:55+02:00 The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. Kalsi, G Mankoo, BS Brynjolfsson, J Curtis, D Read, T Murphy, P Sharma, T Petursson, H Gurling, HM 1994 http://discovery.ucl.ac.uk/88957/ unknown Psychiatr Genet , 4 (4) pp. 219-227. (1994) Chromosomes Human Pair 15 DNA Female Fibrillins Genetic Predisposition to Disease Humans Iceland Lod Score Male Marfan Syndrome Microfilament Proteins Pedigree Schizophrenia Single-Blind Method United Kingdom Article 1994 ftucl 2016-12-29T23:10:45Z Marfan syndrome (MS) is a rare autosomal dominant disorder of connective tissue with manifestations in the cardiovascular, ocular and skeletal systems. Genetic linkage analysis with random probes has mapped the MS locus to 15q21.1. There have been several reports of Marfan syndrome co-segregating with schizophrenia within families, which suggest that a common genetic factor may be shared between schizophrenia susceptibility and MS. This could be due to a cytogenetic abnormality affecting both genetic loci or due to co-segregation of two disease loci near each other on the same chromosome. We tested this hypothesis by using genetic linkage analysis with multiplex families. Using three genetic markers spanning the MS locus, we were unable to find evidence of linkage with schizophrenia across the Marfan syndrome locus on chromosome 15. Article in Journal/Newspaper Iceland University College London: UCL Discovery |
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Open Polar |
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University College London: UCL Discovery |
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unknown |
topic |
Chromosomes Human Pair 15 DNA Female Fibrillins Genetic Predisposition to Disease Humans Iceland Lod Score Male Marfan Syndrome Microfilament Proteins Pedigree Schizophrenia Single-Blind Method United Kingdom |
spellingShingle |
Chromosomes Human Pair 15 DNA Female Fibrillins Genetic Predisposition to Disease Humans Iceland Lod Score Male Marfan Syndrome Microfilament Proteins Pedigree Schizophrenia Single-Blind Method United Kingdom Kalsi, G Mankoo, BS Brynjolfsson, J Curtis, D Read, T Murphy, P Sharma, T Petursson, H Gurling, HM The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
topic_facet |
Chromosomes Human Pair 15 DNA Female Fibrillins Genetic Predisposition to Disease Humans Iceland Lod Score Male Marfan Syndrome Microfilament Proteins Pedigree Schizophrenia Single-Blind Method United Kingdom |
description |
Marfan syndrome (MS) is a rare autosomal dominant disorder of connective tissue with manifestations in the cardiovascular, ocular and skeletal systems. Genetic linkage analysis with random probes has mapped the MS locus to 15q21.1. There have been several reports of Marfan syndrome co-segregating with schizophrenia within families, which suggest that a common genetic factor may be shared between schizophrenia susceptibility and MS. This could be due to a cytogenetic abnormality affecting both genetic loci or due to co-segregation of two disease loci near each other on the same chromosome. We tested this hypothesis by using genetic linkage analysis with multiplex families. Using three genetic markers spanning the MS locus, we were unable to find evidence of linkage with schizophrenia across the Marfan syndrome locus on chromosome 15. |
format |
Article in Journal/Newspaper |
author |
Kalsi, G Mankoo, BS Brynjolfsson, J Curtis, D Read, T Murphy, P Sharma, T Petursson, H Gurling, HM |
author_facet |
Kalsi, G Mankoo, BS Brynjolfsson, J Curtis, D Read, T Murphy, P Sharma, T Petursson, H Gurling, HM |
author_sort |
Kalsi, G |
title |
The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
title_short |
The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
title_full |
The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
title_fullStr |
The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
title_full_unstemmed |
The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
title_sort |
marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia. |
publishDate |
1994 |
url |
http://discovery.ucl.ac.uk/88957/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Psychiatr Genet , 4 (4) pp. 219-227. (1994) |
_version_ |
1766040090057900032 |