Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Background Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes.Methods A birth-cohort study was done, in which all pregn...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:7947 2023-05-15T17:42:46+02:00 Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study Hypponen, E Laara, E Reunanene, A Jarvelin, MR Virtanen, SM 2001-11-03 http://discovery.ucl.ac.uk/7947/ unknown LANCET LTD LANCET , 358 (9292) 1500 - 1503. (2001) FINNISH CHILDREN NOD MICE MELLITUS DISEASE ONSET Article 2001 ftucl 2016-09-01T22:18:04Z Background Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes.Methods A birth-cohort study was done, in which all pregnant women (n=12055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D supplementation and presence of suspected rickets. Our primary outcome measure was diagnosis of type 1 diabetes by end of December, 1997.Findings 12058 of 12231 represented live births, and 10821 (91% of those alive) children were followed-up at age 1 year. Of the 10366 children included in analyses, 81 were diagnosed with diabetes during the study. Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics (rate ratio [RR] for regular vs no supplementation 0.12, 95% CI 0.03-0.51, and irregular vs no supplementation 0.16, 0.04-0.74. Children who regularly took the recommended dose of vitamin D (2000 IU daily) had a RR of 0.22 (0.05-0.89) compared with those who regularly received less than the recommended amount. Children suspected of having rickets during the first year of life had a RR of 3.0 (1.0-9.0) compared with those without such a suspicion.Interpretation Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes. Article in Journal/Newspaper Northern Finland Lapland University College London: UCL Discovery |
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University College London: UCL Discovery |
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FINNISH CHILDREN NOD MICE MELLITUS DISEASE ONSET |
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FINNISH CHILDREN NOD MICE MELLITUS DISEASE ONSET Hypponen, E Laara, E Reunanene, A Jarvelin, MR Virtanen, SM Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
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FINNISH CHILDREN NOD MICE MELLITUS DISEASE ONSET |
description |
Background Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes.Methods A birth-cohort study was done, in which all pregnant women (n=12055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D supplementation and presence of suspected rickets. Our primary outcome measure was diagnosis of type 1 diabetes by end of December, 1997.Findings 12058 of 12231 represented live births, and 10821 (91% of those alive) children were followed-up at age 1 year. Of the 10366 children included in analyses, 81 were diagnosed with diabetes during the study. Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics (rate ratio [RR] for regular vs no supplementation 0.12, 95% CI 0.03-0.51, and irregular vs no supplementation 0.16, 0.04-0.74. Children who regularly took the recommended dose of vitamin D (2000 IU daily) had a RR of 0.22 (0.05-0.89) compared with those who regularly received less than the recommended amount. Children suspected of having rickets during the first year of life had a RR of 3.0 (1.0-9.0) compared with those without such a suspicion.Interpretation Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes. |
format |
Article in Journal/Newspaper |
author |
Hypponen, E Laara, E Reunanene, A Jarvelin, MR Virtanen, SM |
author_facet |
Hypponen, E Laara, E Reunanene, A Jarvelin, MR Virtanen, SM |
author_sort |
Hypponen, E |
title |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
title_short |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
title_full |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
title_fullStr |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
title_full_unstemmed |
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study |
title_sort |
intake of vitamin d and risk of type 1 diabetes: a birth-cohort study |
publisher |
LANCET LTD |
publishDate |
2001 |
url |
http://discovery.ucl.ac.uk/7947/ |
genre |
Northern Finland Lapland |
genre_facet |
Northern Finland Lapland |
op_source |
LANCET , 358 (9292) 1500 - 1503. (2001) |
_version_ |
1766144685421625344 |