Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control
OBJECTIVE: Defective NO release/response may contribute to increased coronary risk and the loss of sex difference in coronary heart disease in diabetes. We aimed to determine whether NO release/response is impaired in type 1 diabetes and whether any defects are greater in women than men. METHODS AND...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:29944 2023-05-15T16:32:13+02:00 Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control Chan, NN Vallance, P Colhoun, HM 2003-06-01 http://discovery.ucl.ac.uk/29944/ unknown Arteriosclerosis, Thrombosis, and Vascular Biology , 23 (6) pp. 1048-1054. (2003) control diabetes DYSFUNCTION factors GLYCEMIC CONTROL Risk RISK FACTOR Risk Factors RISK-FACTORS Sex TYPE-1 vascular Acetylcholine ACh adult Aged AGENT AGENTS agonists analysis Blood blood flow Blood Glucose blood supply BLOOD-FLOW Bradykinin Cohort Studies Comparative Study CORONARY CORONARY HEART DISEASE CORONARY-HEART-DISEASE DEFECT DEFECTS Diabetes Mellitus Type I diabetic diagnostic use difference disease DONOR DONORS Dose-Response Relationship Drug drug effects DRUGS Endothelium epidemiology Female flow Forearm Glucose heart HEART DISEASE HEART-DISEASE IM IMPAIRMENT interaction LA Male May MEN Methods nitric oxide Nitric Oxide Donors NITRIC-OXIDE Nitroglycerin omega-N-Methylarginine OXIDE Patient patients pharmacology physiology physiopathology PLETHYSMOGRAPHY Regional Blood Flow release response Result Sex Factors Support Non-U.S.Gov't VASOCONSTRICTOR Vasoconstrictor Agents Vasodilator Agents Venous WOMEN Article 2003 ftucl 2017-04-06T22:25:04Z OBJECTIVE: Defective NO release/response may contribute to increased coronary risk and the loss of sex difference in coronary heart disease in diabetes. We aimed to determine whether NO release/response is impaired in type 1 diabetes and whether any defects are greater in women than men. METHODS AND RESULTS: Forearm blood flow response to vasoactive drugs was assessed by venous plethysmography in 88 diabetic and 69 control subjects aged 30 to 53 years. In diabetic patients, response was 18% lower for acetylcholine (ACh) (P=0.002), 6% lower for bradykinin (P=0.14), and 17% lower for glyceryl trinitrate (GTN) (P<0.001). Women had a higher response to ACh than men (17%, P=0.006). The diabetes-associated defect in ACh was greater in women (25% lower, P=0.01) than men (13% lower, P=0.08), although not significantly (P=0.26 for the interaction). Poorer glycemic control was associated with ACh response (P=0.003) and contributed to the greater defect in diabetic women than men. CONCLUSIONS: The diabetes-associated defect in GTN response was similar in men and women. Established coronary heart disease risk factors did not explain any of the defects in ACh or GTN response associated with diabetes. Type 1 diabetes is associated with impaired responsiveness to NO and with an impairment in ACh-stimulated NO release Article in Journal/Newspaper GTN-P University College London: UCL Discovery |
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University College London: UCL Discovery |
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ftucl |
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unknown |
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control diabetes DYSFUNCTION factors GLYCEMIC CONTROL Risk RISK FACTOR Risk Factors RISK-FACTORS Sex TYPE-1 vascular Acetylcholine ACh adult Aged AGENT AGENTS agonists analysis Blood blood flow Blood Glucose blood supply BLOOD-FLOW Bradykinin Cohort Studies Comparative Study CORONARY CORONARY HEART DISEASE CORONARY-HEART-DISEASE DEFECT DEFECTS Diabetes Mellitus Type I diabetic diagnostic use difference disease DONOR DONORS Dose-Response Relationship Drug drug effects DRUGS Endothelium epidemiology Female flow Forearm Glucose heart HEART DISEASE HEART-DISEASE IM IMPAIRMENT interaction LA Male May MEN Methods nitric oxide Nitric Oxide Donors NITRIC-OXIDE Nitroglycerin omega-N-Methylarginine OXIDE Patient patients pharmacology physiology physiopathology PLETHYSMOGRAPHY Regional Blood Flow release response Result Sex Factors Support Non-U.S.Gov't VASOCONSTRICTOR Vasoconstrictor Agents Vasodilator Agents Venous WOMEN |
spellingShingle |
control diabetes DYSFUNCTION factors GLYCEMIC CONTROL Risk RISK FACTOR Risk Factors RISK-FACTORS Sex TYPE-1 vascular Acetylcholine ACh adult Aged AGENT AGENTS agonists analysis Blood blood flow Blood Glucose blood supply BLOOD-FLOW Bradykinin Cohort Studies Comparative Study CORONARY CORONARY HEART DISEASE CORONARY-HEART-DISEASE DEFECT DEFECTS Diabetes Mellitus Type I diabetic diagnostic use difference disease DONOR DONORS Dose-Response Relationship Drug drug effects DRUGS Endothelium epidemiology Female flow Forearm Glucose heart HEART DISEASE HEART-DISEASE IM IMPAIRMENT interaction LA Male May MEN Methods nitric oxide Nitric Oxide Donors NITRIC-OXIDE Nitroglycerin omega-N-Methylarginine OXIDE Patient patients pharmacology physiology physiopathology PLETHYSMOGRAPHY Regional Blood Flow release response Result Sex Factors Support Non-U.S.Gov't VASOCONSTRICTOR Vasoconstrictor Agents Vasodilator Agents Venous WOMEN Chan, NN Vallance, P Colhoun, HM Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
topic_facet |
control diabetes DYSFUNCTION factors GLYCEMIC CONTROL Risk RISK FACTOR Risk Factors RISK-FACTORS Sex TYPE-1 vascular Acetylcholine ACh adult Aged AGENT AGENTS agonists analysis Blood blood flow Blood Glucose blood supply BLOOD-FLOW Bradykinin Cohort Studies Comparative Study CORONARY CORONARY HEART DISEASE CORONARY-HEART-DISEASE DEFECT DEFECTS Diabetes Mellitus Type I diabetic diagnostic use difference disease DONOR DONORS Dose-Response Relationship Drug drug effects DRUGS Endothelium epidemiology Female flow Forearm Glucose heart HEART DISEASE HEART-DISEASE IM IMPAIRMENT interaction LA Male May MEN Methods nitric oxide Nitric Oxide Donors NITRIC-OXIDE Nitroglycerin omega-N-Methylarginine OXIDE Patient patients pharmacology physiology physiopathology PLETHYSMOGRAPHY Regional Blood Flow release response Result Sex Factors Support Non-U.S.Gov't VASOCONSTRICTOR Vasoconstrictor Agents Vasodilator Agents Venous WOMEN |
description |
OBJECTIVE: Defective NO release/response may contribute to increased coronary risk and the loss of sex difference in coronary heart disease in diabetes. We aimed to determine whether NO release/response is impaired in type 1 diabetes and whether any defects are greater in women than men. METHODS AND RESULTS: Forearm blood flow response to vasoactive drugs was assessed by venous plethysmography in 88 diabetic and 69 control subjects aged 30 to 53 years. In diabetic patients, response was 18% lower for acetylcholine (ACh) (P=0.002), 6% lower for bradykinin (P=0.14), and 17% lower for glyceryl trinitrate (GTN) (P<0.001). Women had a higher response to ACh than men (17%, P=0.006). The diabetes-associated defect in ACh was greater in women (25% lower, P=0.01) than men (13% lower, P=0.08), although not significantly (P=0.26 for the interaction). Poorer glycemic control was associated with ACh response (P=0.003) and contributed to the greater defect in diabetic women than men. CONCLUSIONS: The diabetes-associated defect in GTN response was similar in men and women. Established coronary heart disease risk factors did not explain any of the defects in ACh or GTN response associated with diabetes. Type 1 diabetes is associated with impaired responsiveness to NO and with an impairment in ACh-stimulated NO release |
format |
Article in Journal/Newspaper |
author |
Chan, NN Vallance, P Colhoun, HM |
author_facet |
Chan, NN Vallance, P Colhoun, HM |
author_sort |
Chan, NN |
title |
Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
title_short |
Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
title_full |
Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
title_fullStr |
Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
title_full_unstemmed |
Endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
title_sort |
endothelium-dependent and -independent vascular dysfunction in type 1 diabetes: role of conventional risk factors, sex, and glycemic control |
publishDate |
2003 |
url |
http://discovery.ucl.ac.uk/29944/ |
genre |
GTN-P |
genre_facet |
GTN-P |
op_source |
Arteriosclerosis, Thrombosis, and Vascular Biology , 23 (6) pp. 1048-1054. (2003) |
_version_ |
1766021975743922176 |