Sex-specific, male-line transgenerational responses in humans
Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:183305 2023-05-15T17:44:53+02:00 Sex-specific, male-line transgenerational responses in humans Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjostrom, M Golding, J 2006-02 http://discovery.ucl.ac.uk/183305/ unknown EUR J HUM GENET , 14 (2) 159 - 166. (2006) Child genetics Humans Male mortality Article 2006 ftucl 2013-11-10T03:13:56Z Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow growth period (SGP) in mid childhood have been reported. Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we identified 166 fathers who reported starting smoking before age 11 years and compared the growth of their offspring with those with a later paternal onset of smoking, after correcting for confounders. We analysed food supply effects on offspring and grandchild mortality risk ratios (RR) using 303 probands and their 1818 parents and grandparents from the 1890, 1905 and 1920 Overkalix cohorts, northern Sweden. After appropriate adjustment, early paternal smoking is associated with greater body mass index (BMI) at 9 years in sons, but not daughters. Sex-specific effects were also shown in the Overkalix data; paternal grandfather's food supply was only linked to the mortality RR of grandsons, while paternal grandmother's food supply was only associated with the granddaughters' mortality RR. These transgenerational effects were observed with exposure during the SGP (both grandparents) or fetal/infant life (grandmothers) but not during either grandparent's puberty. We conclude that sex-specific, male-line transgenerational responses exist in humans and hypothesise that these transmissions are mediated by the sex chromosomes, X and Y. Such responses add an entirely new dimension to the study of gene-environment interactions in development and health Article in Journal/Newspaper Northern Sweden University College London: UCL Discovery |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
unknown |
topic |
Child genetics Humans Male mortality |
spellingShingle |
Child genetics Humans Male mortality Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjostrom, M Golding, J Sex-specific, male-line transgenerational responses in humans |
topic_facet |
Child genetics Humans Male mortality |
description |
Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow growth period (SGP) in mid childhood have been reported. Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we identified 166 fathers who reported starting smoking before age 11 years and compared the growth of their offspring with those with a later paternal onset of smoking, after correcting for confounders. We analysed food supply effects on offspring and grandchild mortality risk ratios (RR) using 303 probands and their 1818 parents and grandparents from the 1890, 1905 and 1920 Overkalix cohorts, northern Sweden. After appropriate adjustment, early paternal smoking is associated with greater body mass index (BMI) at 9 years in sons, but not daughters. Sex-specific effects were also shown in the Overkalix data; paternal grandfather's food supply was only linked to the mortality RR of grandsons, while paternal grandmother's food supply was only associated with the granddaughters' mortality RR. These transgenerational effects were observed with exposure during the SGP (both grandparents) or fetal/infant life (grandmothers) but not during either grandparent's puberty. We conclude that sex-specific, male-line transgenerational responses exist in humans and hypothesise that these transmissions are mediated by the sex chromosomes, X and Y. Such responses add an entirely new dimension to the study of gene-environment interactions in development and health |
format |
Article in Journal/Newspaper |
author |
Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjostrom, M Golding, J |
author_facet |
Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjostrom, M Golding, J |
author_sort |
Pembrey, ME |
title |
Sex-specific, male-line transgenerational responses in humans |
title_short |
Sex-specific, male-line transgenerational responses in humans |
title_full |
Sex-specific, male-line transgenerational responses in humans |
title_fullStr |
Sex-specific, male-line transgenerational responses in humans |
title_full_unstemmed |
Sex-specific, male-line transgenerational responses in humans |
title_sort |
sex-specific, male-line transgenerational responses in humans |
publishDate |
2006 |
url |
http://discovery.ucl.ac.uk/183305/ |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
EUR J HUM GENET , 14 (2) 159 - 166. (2006) |
_version_ |
1766147181361758208 |