Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations
Objective: To evaluate the risk of peripheral anterior synechiae (PAS) and glaucomatous optic neuropathy attributable to primary angle closure at varying anterior chamber depths (ACDs) in two East Asian populations.Methods: Participants 40 years and older were from 2 population-based glaucoma survey...
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2005
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ftucl:oai:eprints.ucl.ac.uk.OAI2:142617 2023-05-15T16:29:39+02:00 Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations Aung, T Nolan, WP Machin, D Seah, SKL Baasanhu, J Khaw, PT Johnson, GJ Foster, PJ 2005-04 http://discovery.ucl.ac.uk/142617/ unknown AMER MEDICAL ASSOC ARCHIVES OF OPHTHALMOLOGY , 123 (4) 527 - 532. (2005) OCULAR BIOMETRY SOUTHERN INDIA 5-YEAR RISK GLAUCOMA PREVALENCE CHINESE EPIDEMIOLOGY PROGRESSION IRIDECTOMY GREENLAND Article 2005 ftucl 2016-01-15T03:26:53Z Objective: To evaluate the risk of peripheral anterior synechiae (PAS) and glaucomatous optic neuropathy attributable to primary angle closure at varying anterior chamber depths (ACDs) in two East Asian populations.Methods: Participants 40 years and older were from 2 population-based glaucoma surveys in Mongolia and Singapore. Central ACD was measured by optical pachymetry. Presence of PAS was determined by dynamic gonioscopy. Cases with secondary PAS were excluded. Glaucomatous optic neuropathy was diagnosed in subjects with structural and functional evidence of glaucoma.Results: A total of 2032 subjects, consisting of 942 Mongolians and 1090 Chinese Singaporeans, were included in this study. A logistic model of the relationship between ACD and PAS among Singaporeans showed a consistent, incremental increase in PAS across the entire range of ACD. In deeper anterior chambers the rate of PAS exceeded that seen in Mongolians. In Mongolians, there was a clear threshold for ACD (2.4 mm) at or above which PAS were very uncommon. With ACD less than 2.4 mm, the rate of PAS rose rapidly to overtake that seen in Singaporeans.Conclusions: Shallow anterior chambers are a significant risk factor for angle closure in East Asians, although the nature of the association is specific to the individual population. There was a trend toward higher rates of glaucomatous optic neuropathy in people with the shallowest anterior chambers. Article in Journal/Newspaper Greenland University College London: UCL Discovery Greenland |
institution |
Open Polar |
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University College London: UCL Discovery |
op_collection_id |
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unknown |
topic |
OCULAR BIOMETRY SOUTHERN INDIA 5-YEAR RISK GLAUCOMA PREVALENCE CHINESE EPIDEMIOLOGY PROGRESSION IRIDECTOMY GREENLAND |
spellingShingle |
OCULAR BIOMETRY SOUTHERN INDIA 5-YEAR RISK GLAUCOMA PREVALENCE CHINESE EPIDEMIOLOGY PROGRESSION IRIDECTOMY GREENLAND Aung, T Nolan, WP Machin, D Seah, SKL Baasanhu, J Khaw, PT Johnson, GJ Foster, PJ Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
topic_facet |
OCULAR BIOMETRY SOUTHERN INDIA 5-YEAR RISK GLAUCOMA PREVALENCE CHINESE EPIDEMIOLOGY PROGRESSION IRIDECTOMY GREENLAND |
description |
Objective: To evaluate the risk of peripheral anterior synechiae (PAS) and glaucomatous optic neuropathy attributable to primary angle closure at varying anterior chamber depths (ACDs) in two East Asian populations.Methods: Participants 40 years and older were from 2 population-based glaucoma surveys in Mongolia and Singapore. Central ACD was measured by optical pachymetry. Presence of PAS was determined by dynamic gonioscopy. Cases with secondary PAS were excluded. Glaucomatous optic neuropathy was diagnosed in subjects with structural and functional evidence of glaucoma.Results: A total of 2032 subjects, consisting of 942 Mongolians and 1090 Chinese Singaporeans, were included in this study. A logistic model of the relationship between ACD and PAS among Singaporeans showed a consistent, incremental increase in PAS across the entire range of ACD. In deeper anterior chambers the rate of PAS exceeded that seen in Mongolians. In Mongolians, there was a clear threshold for ACD (2.4 mm) at or above which PAS were very uncommon. With ACD less than 2.4 mm, the rate of PAS rose rapidly to overtake that seen in Singaporeans.Conclusions: Shallow anterior chambers are a significant risk factor for angle closure in East Asians, although the nature of the association is specific to the individual population. There was a trend toward higher rates of glaucomatous optic neuropathy in people with the shallowest anterior chambers. |
format |
Article in Journal/Newspaper |
author |
Aung, T Nolan, WP Machin, D Seah, SKL Baasanhu, J Khaw, PT Johnson, GJ Foster, PJ |
author_facet |
Aung, T Nolan, WP Machin, D Seah, SKL Baasanhu, J Khaw, PT Johnson, GJ Foster, PJ |
author_sort |
Aung, T |
title |
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
title_short |
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
title_full |
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
title_fullStr |
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
title_full_unstemmed |
Anterior chamber depth and the risk of primary angle closure in 2 East Asian populations |
title_sort |
anterior chamber depth and the risk of primary angle closure in 2 east asian populations |
publisher |
AMER MEDICAL ASSOC |
publishDate |
2005 |
url |
http://discovery.ucl.ac.uk/142617/ |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
ARCHIVES OF OPHTHALMOLOGY , 123 (4) 527 - 532. (2005) |
_version_ |
1766019354315456512 |