Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits.
Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXR...
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ftucl:oai:eprints.ucl.ac.uk.OAI2:1424663 2023-05-15T17:42:35+02:00 Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. Vimaleswaran, KS Cavadino, A Berry, DJ Mangino, M Andrews, P Moore, JH Spector, TD Power, C Järvelin, MR Hyppönen, E 2014 http://discovery.ucl.ac.uk/1424663/ eng eng BMC Genet , 15 37 - ?. (2014) Alleles Blood Pressure Body Mass Index Cholesterol HDL LDL Cohort Studies Finland Great Britain Hemoglobin A Glycosylated Humans Likelihood Functions Models Genetic Polymorphism Single Nucleotide Receptors Calcitriol Retinoid X Receptors Triglycerides Twin Studies as Topic Waist Circumference Waist-Hip Ratio Article 2014 ftucl 2015-02-12T23:34:28Z Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 British Birth Cohort (1958BC, up to n = 5,231). We used Multifactor- dimensionality reduction (MDR) program as a non-parametric test to examine for potential interactions between the VDR and RXRG gene polymorphisms in the 1958BC. We used the data from Northern Finland Birth Cohort 1966 (NFBC66, up to n = 5,316) and Twins UK (up to n = 3,943) to replicate our initial findings from 1958BC. Article in Journal/Newspaper Northern Finland University College London: UCL Discovery |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
English |
topic |
Alleles Blood Pressure Body Mass Index Cholesterol HDL LDL Cohort Studies Finland Great Britain Hemoglobin A Glycosylated Humans Likelihood Functions Models Genetic Polymorphism Single Nucleotide Receptors Calcitriol Retinoid X Receptors Triglycerides Twin Studies as Topic Waist Circumference Waist-Hip Ratio |
spellingShingle |
Alleles Blood Pressure Body Mass Index Cholesterol HDL LDL Cohort Studies Finland Great Britain Hemoglobin A Glycosylated Humans Likelihood Functions Models Genetic Polymorphism Single Nucleotide Receptors Calcitriol Retinoid X Receptors Triglycerides Twin Studies as Topic Waist Circumference Waist-Hip Ratio Vimaleswaran, KS Cavadino, A Berry, DJ Mangino, M Andrews, P Moore, JH Spector, TD Power, C Järvelin, MR Hyppönen, E Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
topic_facet |
Alleles Blood Pressure Body Mass Index Cholesterol HDL LDL Cohort Studies Finland Great Britain Hemoglobin A Glycosylated Humans Likelihood Functions Models Genetic Polymorphism Single Nucleotide Receptors Calcitriol Retinoid X Receptors Triglycerides Twin Studies as Topic Waist Circumference Waist-Hip Ratio |
description |
Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 British Birth Cohort (1958BC, up to n = 5,231). We used Multifactor- dimensionality reduction (MDR) program as a non-parametric test to examine for potential interactions between the VDR and RXRG gene polymorphisms in the 1958BC. We used the data from Northern Finland Birth Cohort 1966 (NFBC66, up to n = 5,316) and Twins UK (up to n = 3,943) to replicate our initial findings from 1958BC. |
format |
Article in Journal/Newspaper |
author |
Vimaleswaran, KS Cavadino, A Berry, DJ Mangino, M Andrews, P Moore, JH Spector, TD Power, C Järvelin, MR Hyppönen, E |
author_facet |
Vimaleswaran, KS Cavadino, A Berry, DJ Mangino, M Andrews, P Moore, JH Spector, TD Power, C Järvelin, MR Hyppönen, E |
author_sort |
Vimaleswaran, KS |
title |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
title_short |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
title_full |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
title_fullStr |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
title_full_unstemmed |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. |
title_sort |
interaction between allelic variations in vitamin d receptor and retinoid x receptor genes on metabolic traits. |
publishDate |
2014 |
url |
http://discovery.ucl.ac.uk/1424663/ |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
BMC Genet , 15 37 - ?. (2014) |
_version_ |
1766144471118905344 |