Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity
The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances...
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Oxford University Press (OUP)
2022
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ftucl:oai:eprints.ucl.ac.uk.OAI2:10171130 2023-12-24T10:14:47+01:00 Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U 2022-02 text https://discovery.ucl.ac.uk/id/eprint/10171130/1/Rodriguez_MS3-Supercomplexes_JofGA_reviewed_final.pdf https://discovery.ucl.ac.uk/id/eprint/10171130/ eng eng Oxford University Press (OUP) https://discovery.ucl.ac.uk/id/eprint/10171130/1/Rodriguez_MS3-Supercomplexes_JofGA_reviewed_final.pdf https://discovery.ucl.ac.uk/id/eprint/10171130/ open The Journals of Gerontology: Series A , 77 (2) pp. 283-290. (2022) Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Electron transfer system Invertebrate Mitochondria Supercomplex ARCTICA-ISLANDICA RESPIRATORY-CHAIN MITOCHONDRIAL MECHANISM GROWTH CLAM FLUX Article 2022 ftucl 2023-11-27T13:07:35Z The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances in understanding the structure of the ETS show that the enzymatic complexes responsible for oxidative phosphorylation are arranged in supramolecular structures called supercomplexes that lose organization during aging. Their exact role and universality among organisms are still under debate. Here, we take advantage of marine bivalves as an aging model to compare the structure of the ETS among species ranging from 28 to 507 years in maximal life span. Our results show that regardless of life span, the bivalve ETS is arrayed as a set of supercomplexes. However, bivalve species display varying degrees of ETS supramolecular organization with the highest supercomplex structures found in Arctica islandica, the longest-lived of the bivalve species under study. We discuss this comparative model in light of differences in the nature and stoichiometry of these complexes and highlight the potential link between the complexity of these superstructures and longer life spans. Article in Journal/Newspaper Arctica islandica University College London: UCL Discovery |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
English |
topic |
Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Electron transfer system Invertebrate Mitochondria Supercomplex ARCTICA-ISLANDICA RESPIRATORY-CHAIN MITOCHONDRIAL MECHANISM GROWTH CLAM FLUX |
spellingShingle |
Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Electron transfer system Invertebrate Mitochondria Supercomplex ARCTICA-ISLANDICA RESPIRATORY-CHAIN MITOCHONDRIAL MECHANISM GROWTH CLAM FLUX Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
topic_facet |
Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Electron transfer system Invertebrate Mitochondria Supercomplex ARCTICA-ISLANDICA RESPIRATORY-CHAIN MITOCHONDRIAL MECHANISM GROWTH CLAM FLUX |
description |
The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances in understanding the structure of the ETS show that the enzymatic complexes responsible for oxidative phosphorylation are arranged in supramolecular structures called supercomplexes that lose organization during aging. Their exact role and universality among organisms are still under debate. Here, we take advantage of marine bivalves as an aging model to compare the structure of the ETS among species ranging from 28 to 507 years in maximal life span. Our results show that regardless of life span, the bivalve ETS is arrayed as a set of supercomplexes. However, bivalve species display varying degrees of ETS supramolecular organization with the highest supercomplex structures found in Arctica islandica, the longest-lived of the bivalve species under study. We discuss this comparative model in light of differences in the nature and stoichiometry of these complexes and highlight the potential link between the complexity of these superstructures and longer life spans. |
format |
Article in Journal/Newspaper |
author |
Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U |
author_facet |
Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U |
author_sort |
Rodríguez, Enrique |
title |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_short |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_full |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_fullStr |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_full_unstemmed |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_sort |
supercomplex organization of the electron transfer system in marine bivalves, a model of extreme longevity |
publisher |
Oxford University Press (OUP) |
publishDate |
2022 |
url |
https://discovery.ucl.ac.uk/id/eprint/10171130/1/Rodriguez_MS3-Supercomplexes_JofGA_reviewed_final.pdf https://discovery.ucl.ac.uk/id/eprint/10171130/ |
genre |
Arctica islandica |
genre_facet |
Arctica islandica |
op_source |
The Journals of Gerontology: Series A , 77 (2) pp. 283-290. (2022) |
op_relation |
https://discovery.ucl.ac.uk/id/eprint/10171130/1/Rodriguez_MS3-Supercomplexes_JofGA_reviewed_final.pdf https://discovery.ucl.ac.uk/id/eprint/10171130/ |
op_rights |
open |
_version_ |
1786197738852974592 |