Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids
Natural cases of zooanthroponotic transmission of SARS-CoV-2 to animals have been reported during the COVID-19 pandemic, including to free-ranging white-tailed deer (Odocoileus virginianus) in North America and farmed American mink (Neovison vison) on multiple continents. To understand the potential...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier BV
2023
|
Subjects: | |
Online Access: | https://discovery.ucl.ac.uk/id/eprint/10165592/1/Lean%20et%20al%202023.pdf https://discovery.ucl.ac.uk/id/eprint/10165592/ |
id |
ftucl:oai:eprints.ucl.ac.uk.OAI2:10165592 |
---|---|
record_format |
openpolar |
spelling |
ftucl:oai:eprints.ucl.ac.uk.OAI2:10165592 2023-12-24T10:07:50+01:00 Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids Lean, Fabian ZX Cox, Ruth Madslien, Knut Spiro, Simon Nymo, Ingebjørg Helena Bröjer, Caroline Neimanis, Aleksija Lawson, Becki Holmes, Paul Man, Catherine Folkow, Lars P Gough, Julie Ackroyd, Stuart Evans, Liam Wrigglesworth, Ethan Grimholt, Unni McElhinney, Lorraine Brookes, Sharon M Delahay, Richard J Núñez, Alejandro 2023-06 application/pdf https://discovery.ucl.ac.uk/id/eprint/10165592/1/Lean%20et%20al%202023.pdf https://discovery.ucl.ac.uk/id/eprint/10165592/ eng eng Elsevier BV https://discovery.ucl.ac.uk/id/eprint/10165592/1/Lean%20et%20al%202023.pdf https://discovery.ucl.ac.uk/id/eprint/10165592/ open One Health , 16 , Article 100492. (2023) ACE2 Wildlife Ungulate Mustelid Phocid Respiratory tract Intestinal tract Article 2023 ftucl 2023-11-27T13:07:31Z Natural cases of zooanthroponotic transmission of SARS-CoV-2 to animals have been reported during the COVID-19 pandemic, including to free-ranging white-tailed deer (Odocoileus virginianus) in North America and farmed American mink (Neovison vison) on multiple continents. To understand the potential for angiotensin-converting enzyme 2 (ACE2)-mediated viral tropism we characterised the distribution of ACE2 receptors in the respiratory and intestinal tissues of a selection of wild and semi-domesticated mammals including artiodactyls (cervids, bovids, camelids, suids and hippopotamus), mustelid and phocid species using immunohistochemistry. Expression of the ACE2 receptor was detected in the bronchial or bronchiolar epithelium of several European and Asiatic deer species, Bactrian camel (Camelus bactrianus), European badger (Meles meles), stoat (Mustela erminea), hippopotamus (Hippopotamus amphibious), harbor seal (Phoca vitulina), and hooded seal (Cystophora cristata). Further receptor mapping in the nasal turbinates and trachea revealed sparse ACE2 receptor expression in the mucosal epithelial cells and occasional occurrence in the submucosal glandular epithelium of Western roe deer (Capreolus capreolus), moose (Alces alces alces), and alpaca (Vicunga pacos). Only the European badger and stoat expressed high levels of ACE2 receptor in the nasal mucosal epithelium, which could suggest high susceptibility to ACE2-mediated respiratory infection. Expression of ACE2 receptor in the intestinal cells was ubiquitous across multiple taxa examined. Our results demonstrate the potential for ACE2-mediated viral infection in a selection of wild mammals and highlight the intra-taxon variability of ACE2 receptor expression, which might influence host susceptibility and infection. Article in Journal/Newspaper Alces alces Cystophora cristata harbor seal hooded seal Phoca vitulina University College London: UCL Discovery |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
English |
topic |
ACE2 Wildlife Ungulate Mustelid Phocid Respiratory tract Intestinal tract |
spellingShingle |
ACE2 Wildlife Ungulate Mustelid Phocid Respiratory tract Intestinal tract Lean, Fabian ZX Cox, Ruth Madslien, Knut Spiro, Simon Nymo, Ingebjørg Helena Bröjer, Caroline Neimanis, Aleksija Lawson, Becki Holmes, Paul Man, Catherine Folkow, Lars P Gough, Julie Ackroyd, Stuart Evans, Liam Wrigglesworth, Ethan Grimholt, Unni McElhinney, Lorraine Brookes, Sharon M Delahay, Richard J Núñez, Alejandro Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
topic_facet |
ACE2 Wildlife Ungulate Mustelid Phocid Respiratory tract Intestinal tract |
description |
Natural cases of zooanthroponotic transmission of SARS-CoV-2 to animals have been reported during the COVID-19 pandemic, including to free-ranging white-tailed deer (Odocoileus virginianus) in North America and farmed American mink (Neovison vison) on multiple continents. To understand the potential for angiotensin-converting enzyme 2 (ACE2)-mediated viral tropism we characterised the distribution of ACE2 receptors in the respiratory and intestinal tissues of a selection of wild and semi-domesticated mammals including artiodactyls (cervids, bovids, camelids, suids and hippopotamus), mustelid and phocid species using immunohistochemistry. Expression of the ACE2 receptor was detected in the bronchial or bronchiolar epithelium of several European and Asiatic deer species, Bactrian camel (Camelus bactrianus), European badger (Meles meles), stoat (Mustela erminea), hippopotamus (Hippopotamus amphibious), harbor seal (Phoca vitulina), and hooded seal (Cystophora cristata). Further receptor mapping in the nasal turbinates and trachea revealed sparse ACE2 receptor expression in the mucosal epithelial cells and occasional occurrence in the submucosal glandular epithelium of Western roe deer (Capreolus capreolus), moose (Alces alces alces), and alpaca (Vicunga pacos). Only the European badger and stoat expressed high levels of ACE2 receptor in the nasal mucosal epithelium, which could suggest high susceptibility to ACE2-mediated respiratory infection. Expression of ACE2 receptor in the intestinal cells was ubiquitous across multiple taxa examined. Our results demonstrate the potential for ACE2-mediated viral infection in a selection of wild mammals and highlight the intra-taxon variability of ACE2 receptor expression, which might influence host susceptibility and infection. |
format |
Article in Journal/Newspaper |
author |
Lean, Fabian ZX Cox, Ruth Madslien, Knut Spiro, Simon Nymo, Ingebjørg Helena Bröjer, Caroline Neimanis, Aleksija Lawson, Becki Holmes, Paul Man, Catherine Folkow, Lars P Gough, Julie Ackroyd, Stuart Evans, Liam Wrigglesworth, Ethan Grimholt, Unni McElhinney, Lorraine Brookes, Sharon M Delahay, Richard J Núñez, Alejandro |
author_facet |
Lean, Fabian ZX Cox, Ruth Madslien, Knut Spiro, Simon Nymo, Ingebjørg Helena Bröjer, Caroline Neimanis, Aleksija Lawson, Becki Holmes, Paul Man, Catherine Folkow, Lars P Gough, Julie Ackroyd, Stuart Evans, Liam Wrigglesworth, Ethan Grimholt, Unni McElhinney, Lorraine Brookes, Sharon M Delahay, Richard J Núñez, Alejandro |
author_sort |
Lean, Fabian ZX |
title |
Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
title_short |
Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
title_full |
Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
title_fullStr |
Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
title_full_unstemmed |
Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
title_sort |
tissue distribution of angiotensin-converting enzyme 2 (ace2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids |
publisher |
Elsevier BV |
publishDate |
2023 |
url |
https://discovery.ucl.ac.uk/id/eprint/10165592/1/Lean%20et%20al%202023.pdf https://discovery.ucl.ac.uk/id/eprint/10165592/ |
genre |
Alces alces Cystophora cristata harbor seal hooded seal Phoca vitulina |
genre_facet |
Alces alces Cystophora cristata harbor seal hooded seal Phoca vitulina |
op_source |
One Health , 16 , Article 100492. (2023) |
op_relation |
https://discovery.ucl.ac.uk/id/eprint/10165592/1/Lean%20et%20al%202023.pdf https://discovery.ucl.ac.uk/id/eprint/10165592/ |
op_rights |
open |
_version_ |
1786159734314762240 |