Grey wolf genomic history reveals a dual ancestry of dogs
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when an...
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NATURE PORTFOLIO
2022
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ftucl:oai:eprints.ucl.ac.uk.OAI2:10155116 2023-12-24T10:15:50+01:00 Grey wolf genomic history reveals a dual ancestry of dogs Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O'Drisceoil, Coilin Orlando, Ludovic Outram, Alan Pavlova, Elena Y Perri, Angela R Pilot, Malgorzata Pitulko, Vladimir V Plotnikov, Valerii V Protopopov, Albert V Rehazek, Andre Sablin, Mikhail Seguin-Orlando, Andaine Stora, Jan Verjux, Christian Zaibert, Victor F Zazula, Grant Crombe, Philippe Hansen, Anders J Willerslev, Eske Leonard, Jennifer A Gotherstrom, Anders Pinhasi, Ron Schuenemann, Verena J Hofreiter, Michael Gilbert, M Thomas P Shapiro, Beth Larson, Greger Krause, Johannes Dalen, Love Skoglund, Pontus 2022-06-29 application/pdf https://discovery.ucl.ac.uk/id/eprint/10155116/1/Speidel_Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10155116/ eng eng NATURE PORTFOLIO https://discovery.ucl.ac.uk/id/eprint/10155116/1/Speidel_Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10155116/ open Nature , 607 pp. 313-320. (2022) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics COMPLETE MITOCHONDRIAL GENOME ANCIENT DNA EVOLUTIONARY HISTORY LIBRARY PREPARATION SEQUENCE ADMIXTURE ORIGIN CONTAMINATION DOMESTICATION WOLVES Article 2022 ftucl 2023-11-27T13:07:32Z The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1–8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. Article in Journal/Newspaper Canis lupus Siberia University College London: UCL Discovery |
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University College London: UCL Discovery |
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ftucl |
language |
English |
topic |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics COMPLETE MITOCHONDRIAL GENOME ANCIENT DNA EVOLUTIONARY HISTORY LIBRARY PREPARATION SEQUENCE ADMIXTURE ORIGIN CONTAMINATION DOMESTICATION WOLVES |
spellingShingle |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics COMPLETE MITOCHONDRIAL GENOME ANCIENT DNA EVOLUTIONARY HISTORY LIBRARY PREPARATION SEQUENCE ADMIXTURE ORIGIN CONTAMINATION DOMESTICATION WOLVES Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O'Drisceoil, Coilin Orlando, Ludovic Outram, Alan Pavlova, Elena Y Perri, Angela R Pilot, Malgorzata Pitulko, Vladimir V Plotnikov, Valerii V Protopopov, Albert V Rehazek, Andre Sablin, Mikhail Seguin-Orlando, Andaine Stora, Jan Verjux, Christian Zaibert, Victor F Zazula, Grant Crombe, Philippe Hansen, Anders J Willerslev, Eske Leonard, Jennifer A Gotherstrom, Anders Pinhasi, Ron Schuenemann, Verena J Hofreiter, Michael Gilbert, M Thomas P Shapiro, Beth Larson, Greger Krause, Johannes Dalen, Love Skoglund, Pontus Grey wolf genomic history reveals a dual ancestry of dogs |
topic_facet |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics COMPLETE MITOCHONDRIAL GENOME ANCIENT DNA EVOLUTIONARY HISTORY LIBRARY PREPARATION SEQUENCE ADMIXTURE ORIGIN CONTAMINATION DOMESTICATION WOLVES |
description |
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1–8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. |
format |
Article in Journal/Newspaper |
author |
Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O'Drisceoil, Coilin Orlando, Ludovic Outram, Alan Pavlova, Elena Y Perri, Angela R Pilot, Malgorzata Pitulko, Vladimir V Plotnikov, Valerii V Protopopov, Albert V Rehazek, Andre Sablin, Mikhail Seguin-Orlando, Andaine Stora, Jan Verjux, Christian Zaibert, Victor F Zazula, Grant Crombe, Philippe Hansen, Anders J Willerslev, Eske Leonard, Jennifer A Gotherstrom, Anders Pinhasi, Ron Schuenemann, Verena J Hofreiter, Michael Gilbert, M Thomas P Shapiro, Beth Larson, Greger Krause, Johannes Dalen, Love Skoglund, Pontus |
author_facet |
Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O'Drisceoil, Coilin Orlando, Ludovic Outram, Alan Pavlova, Elena Y Perri, Angela R Pilot, Malgorzata Pitulko, Vladimir V Plotnikov, Valerii V Protopopov, Albert V Rehazek, Andre Sablin, Mikhail Seguin-Orlando, Andaine Stora, Jan Verjux, Christian Zaibert, Victor F Zazula, Grant Crombe, Philippe Hansen, Anders J Willerslev, Eske Leonard, Jennifer A Gotherstrom, Anders Pinhasi, Ron Schuenemann, Verena J Hofreiter, Michael Gilbert, M Thomas P Shapiro, Beth Larson, Greger Krause, Johannes Dalen, Love Skoglund, Pontus |
author_sort |
Bergstrom, Anders |
title |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_short |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_fullStr |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full_unstemmed |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_sort |
grey wolf genomic history reveals a dual ancestry of dogs |
publisher |
NATURE PORTFOLIO |
publishDate |
2022 |
url |
https://discovery.ucl.ac.uk/id/eprint/10155116/1/Speidel_Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10155116/ |
genre |
Canis lupus Siberia |
genre_facet |
Canis lupus Siberia |
op_source |
Nature , 607 pp. 313-320. (2022) |
op_relation |
https://discovery.ucl.ac.uk/id/eprint/10155116/1/Speidel_Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10155116/ |
op_rights |
open |
_version_ |
1786203016231124992 |