Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1–97.6...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
LIPPINCOTT WILLIAMS & WILKINS
2017
|
Subjects: | |
Online Access: | https://discovery.ucl.ac.uk/id/eprint/10067025/1/emss-74083.pdf https://discovery.ucl.ac.uk/id/eprint/10067025/ |
id |
ftucl:oai:eprints.ucl.ac.uk.OAI2:10067025 |
---|---|
record_format |
openpolar |
spelling |
ftucl:oai:eprints.ucl.ac.uk.OAI2:10067025 2023-12-24T10:23:39+01:00 Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) Magnussen, C Niiranen, TJ Ojeda, FM Gianfagna, F Blankenberg, S Njolstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, MB Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, HM Mathiesen, E Jorgensen, T Soderberg, S Kuulasmaa, K Zeller, T Iacoviello, L Salomaa, V Schnabel, RB 2017-10-24 text https://discovery.ucl.ac.uk/id/eprint/10067025/1/emss-74083.pdf https://discovery.ucl.ac.uk/id/eprint/10067025/ eng eng LIPPINCOTT WILLIAMS & WILKINS https://discovery.ucl.ac.uk/id/eprint/10067025/1/emss-74083.pdf https://discovery.ucl.ac.uk/id/eprint/10067025/ open Circulation , 136 (17) pp. 1588-1597. (2017) atrial fibrillation sex epidemiology cohort biomarkers risk assessment mortality Article 2017 ftucl 2023-11-27T13:07:28Z BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1–97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Molisani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12–1.23 in women versus 1.31; 95% CI 1.25–1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81–0.90 versus 0.92; 95% CI, 0.88–0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... Article in Journal/Newspaper Northern Sweden University College London: UCL Discovery |
institution |
Open Polar |
collection |
University College London: UCL Discovery |
op_collection_id |
ftucl |
language |
English |
topic |
atrial fibrillation sex epidemiology cohort biomarkers risk assessment mortality |
spellingShingle |
atrial fibrillation sex epidemiology cohort biomarkers risk assessment mortality Magnussen, C Niiranen, TJ Ojeda, FM Gianfagna, F Blankenberg, S Njolstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, MB Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, HM Mathiesen, E Jorgensen, T Soderberg, S Kuulasmaa, K Zeller, T Iacoviello, L Salomaa, V Schnabel, RB Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
topic_facet |
atrial fibrillation sex epidemiology cohort biomarkers risk assessment mortality |
description |
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1–97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Molisani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12–1.23 in women versus 1.31; 95% CI 1.25–1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81–0.90 versus 0.92; 95% CI, 0.88–0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... |
format |
Article in Journal/Newspaper |
author |
Magnussen, C Niiranen, TJ Ojeda, FM Gianfagna, F Blankenberg, S Njolstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, MB Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, HM Mathiesen, E Jorgensen, T Soderberg, S Kuulasmaa, K Zeller, T Iacoviello, L Salomaa, V Schnabel, RB |
author_facet |
Magnussen, C Niiranen, TJ Ojeda, FM Gianfagna, F Blankenberg, S Njolstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, MB Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, HM Mathiesen, E Jorgensen, T Soderberg, S Kuulasmaa, K Zeller, T Iacoviello, L Salomaa, V Schnabel, RB |
author_sort |
Magnussen, C |
title |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_short |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_fullStr |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full_unstemmed |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_sort |
sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts results from the biomarcare consortium (biomarker for cardiovascular risk assessment in europe) |
publisher |
LIPPINCOTT WILLIAMS & WILKINS |
publishDate |
2017 |
url |
https://discovery.ucl.ac.uk/id/eprint/10067025/1/emss-74083.pdf https://discovery.ucl.ac.uk/id/eprint/10067025/ |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Circulation , 136 (17) pp. 1588-1597. (2017) |
op_relation |
https://discovery.ucl.ac.uk/id/eprint/10067025/1/emss-74083.pdf https://discovery.ucl.ac.uk/id/eprint/10067025/ |
op_rights |
open |
_version_ |
1786197775707275264 |