The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations
Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-direction...
Published in: | Translational Psychiatry |
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2021
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ftubristolcris:oai:research-information.bris.ac.uk:publications/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 2024-05-19T07:45:56+00:00 The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations Karhunen, Ville Bond, Tom Zuber, Verena Hurtig, Tuula Moilanen, Irma Järvelin, Marjo-Riitta Evangelou, Marina Rodriguez, Alina 2021-09-04 application/pdf https://hdl.handle.net/1983/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 https://research-information.bris.ac.uk/en/publications/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 https://doi.org/10.1038/s41398-021-01584-4 https://research-information.bris.ac.uk/ws/files/310577580/s41398_021_01584_4.pdf eng eng https://research-information.bris.ac.uk/en/publications/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 info:eu-repo/semantics/openAccess Karhunen , V , Bond , T , Zuber , V , Hurtig , T , Moilanen , I , Järvelin , M-R , Evangelou , M & Rodriguez , A 2021 , ' The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations ' , Translational Psychiatry , vol. 11 , 455 (2021) . https://doi.org/10.1038/s41398-021-01584-4 article 2021 ftubristolcris https://doi.org/10.1038/s41398-021-01584-4 2024-04-30T23:54:51Z Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference ADHD symptoms and obesity-related traits between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins. Article in Journal/Newspaper Northern Finland University of Bristol: Bristol Research Translational Psychiatry 11 1 |
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University of Bristol: Bristol Research |
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ftubristolcris |
language |
English |
description |
Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference ADHD symptoms and obesity-related traits between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins. |
format |
Article in Journal/Newspaper |
author |
Karhunen, Ville Bond, Tom Zuber, Verena Hurtig, Tuula Moilanen, Irma Järvelin, Marjo-Riitta Evangelou, Marina Rodriguez, Alina |
spellingShingle |
Karhunen, Ville Bond, Tom Zuber, Verena Hurtig, Tuula Moilanen, Irma Järvelin, Marjo-Riitta Evangelou, Marina Rodriguez, Alina The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
author_facet |
Karhunen, Ville Bond, Tom Zuber, Verena Hurtig, Tuula Moilanen, Irma Järvelin, Marjo-Riitta Evangelou, Marina Rodriguez, Alina |
author_sort |
Karhunen, Ville |
title |
The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
title_short |
The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
title_full |
The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
title_fullStr |
The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
title_full_unstemmed |
The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations |
title_sort |
link between attention deficit hyperactivity disorder (adhd) symptoms and obesity-related traits: genetic and prenatal explanations |
publishDate |
2021 |
url |
https://hdl.handle.net/1983/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 https://research-information.bris.ac.uk/en/publications/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 https://doi.org/10.1038/s41398-021-01584-4 https://research-information.bris.ac.uk/ws/files/310577580/s41398_021_01584_4.pdf |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Karhunen , V , Bond , T , Zuber , V , Hurtig , T , Moilanen , I , Järvelin , M-R , Evangelou , M & Rodriguez , A 2021 , ' The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations ' , Translational Psychiatry , vol. 11 , 455 (2021) . https://doi.org/10.1038/s41398-021-01584-4 |
op_relation |
https://research-information.bris.ac.uk/en/publications/fab6ed4f-5026-4ecc-abc6-b12613ec4ee3 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41398-021-01584-4 |
container_title |
Translational Psychiatry |
container_volume |
11 |
container_issue |
1 |
_version_ |
1799486051470802944 |