Sex-specific, male-line transgenerational responses in humans
Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal...
Published in: | European Journal of Human Genetics |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2006
|
Subjects: | |
Online Access: | https://hdl.handle.net/1983/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://research-information.bris.ac.uk/en/publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://doi.org/10.1038/sj.ejhg.5201538 http://www.nature.com/ejhg/journal/v14/n2/abs/5201538a.html |
id |
ftubristolcris:oai:research-information.bris.ac.uk:publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c |
---|---|
record_format |
openpolar |
spelling |
ftubristolcris:oai:research-information.bris.ac.uk:publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c 2024-05-19T07:46:10+00:00 Sex-specific, male-line transgenerational responses in humans Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjöström, M Golding, J the ALSPAC Study, Team 2006-02 https://hdl.handle.net/1983/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://research-information.bris.ac.uk/en/publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://doi.org/10.1038/sj.ejhg.5201538 http://www.nature.com/ejhg/journal/v14/n2/abs/5201538a.html eng eng https://research-information.bris.ac.uk/en/publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c info:eu-repo/semantics/restrictedAccess Pembrey , ME , Bygren , LO , Kaati , G , Edvinsson , S , Northstone , K , Sjöström , M , Golding , J & the ALSPAC Study , T 2006 , ' Sex-specific, male-line transgenerational responses in humans ' , European Journal of Human Genetics , vol. 14 (2) , pp. 159 - 166 . https://doi.org/10.1038/sj.ejhg.5201538 article 2006 ftubristolcris https://doi.org/10.1038/sj.ejhg.5201538 2024-04-30T23:37:13Z Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow growth period (SGP) in mid childhood have been reported. Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we identified 166 fathers who reported starting smoking before age 11 years and compared the growth of their offspring with those with a later paternal onset of smoking, after correcting for confounders. We analysed food supply effects on offspring and grandchild mortality risk ratios (RR) using 303 probands and their 1818 parents and grandparents from the 1890, 1905 and 1920 Överkalix cohorts, northern Sweden. After appropriate adjustment, early paternal smoking is associated with greater body mass index (BMI) at 9 years in sons, but not daughters. Sex-specific effects were also shown in the Överkalix data; paternal grandfather's food supply was only linked to the mortality RR of grandsons, while paternal grandmother's food supply was only associated with the granddaughters' mortality RR. These transgenerational effects were observed with exposure during the SGP (both grandparents) or fetal/infant life (grandmothers) but not during either grandparent's puberty. We conclude that sex-specific, male-line transgenerational responses exist in humans and hypothesise that these transmissions are mediated by the sex chromosomes, X and Y. Such responses add an entirely new dimension to the study of gene–environment interactions in development and health. Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow ... Article in Journal/Newspaper Northern Sweden Överkalix University of Bristol: Bristol Research European Journal of Human Genetics 14 2 159 166 |
institution |
Open Polar |
collection |
University of Bristol: Bristol Research |
op_collection_id |
ftubristolcris |
language |
English |
description |
Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow growth period (SGP) in mid childhood have been reported. Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we identified 166 fathers who reported starting smoking before age 11 years and compared the growth of their offspring with those with a later paternal onset of smoking, after correcting for confounders. We analysed food supply effects on offspring and grandchild mortality risk ratios (RR) using 303 probands and their 1818 parents and grandparents from the 1890, 1905 and 1920 Överkalix cohorts, northern Sweden. After appropriate adjustment, early paternal smoking is associated with greater body mass index (BMI) at 9 years in sons, but not daughters. Sex-specific effects were also shown in the Överkalix data; paternal grandfather's food supply was only linked to the mortality RR of grandsons, while paternal grandmother's food supply was only associated with the granddaughters' mortality RR. These transgenerational effects were observed with exposure during the SGP (both grandparents) or fetal/infant life (grandmothers) but not during either grandparent's puberty. We conclude that sex-specific, male-line transgenerational responses exist in humans and hypothesise that these transmissions are mediated by the sex chromosomes, X and Y. Such responses add an entirely new dimension to the study of gene–environment interactions in development and health. Transgenerational effects of maternal nutrition or other environmental 'exposures' are well recognised, but the possibility of exposure in the male influencing development and health in the next generation(s) is rarely considered. However, historical associations of longevity with paternal ancestors' food supply in the slow ... |
format |
Article in Journal/Newspaper |
author |
Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjöström, M Golding, J the ALSPAC Study, Team |
spellingShingle |
Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjöström, M Golding, J the ALSPAC Study, Team Sex-specific, male-line transgenerational responses in humans |
author_facet |
Pembrey, ME Bygren, LO Kaati, G Edvinsson, S Northstone, K Sjöström, M Golding, J the ALSPAC Study, Team |
author_sort |
Pembrey, ME |
title |
Sex-specific, male-line transgenerational responses in humans |
title_short |
Sex-specific, male-line transgenerational responses in humans |
title_full |
Sex-specific, male-line transgenerational responses in humans |
title_fullStr |
Sex-specific, male-line transgenerational responses in humans |
title_full_unstemmed |
Sex-specific, male-line transgenerational responses in humans |
title_sort |
sex-specific, male-line transgenerational responses in humans |
publishDate |
2006 |
url |
https://hdl.handle.net/1983/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://research-information.bris.ac.uk/en/publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c https://doi.org/10.1038/sj.ejhg.5201538 http://www.nature.com/ejhg/journal/v14/n2/abs/5201538a.html |
genre |
Northern Sweden Överkalix |
genre_facet |
Northern Sweden Överkalix |
op_source |
Pembrey , ME , Bygren , LO , Kaati , G , Edvinsson , S , Northstone , K , Sjöström , M , Golding , J & the ALSPAC Study , T 2006 , ' Sex-specific, male-line transgenerational responses in humans ' , European Journal of Human Genetics , vol. 14 (2) , pp. 159 - 166 . https://doi.org/10.1038/sj.ejhg.5201538 |
op_relation |
https://research-information.bris.ac.uk/en/publications/d6732a7a-ebbf-4dfc-9740-75fcc9b9934c |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1038/sj.ejhg.5201538 |
container_title |
European Journal of Human Genetics |
container_volume |
14 |
container_issue |
2 |
container_start_page |
159 |
op_container_end_page |
166 |
_version_ |
1799486297349292032 |