DI*A and DI*B Allele Frequencies Among Southern Thai Blood Donors

• Published in: Indian Journal of Hematology and Blood Transfusion
• Main Authors: Chesor, Musleeha, Mitundee, Supattra, Nathalang, Siriporn, Thattanon, Phatchira, Intharanut, Kamphon, Tobunluepop, Pussadee, Nathalang, Oytip
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: Allele frequencies; Diego blood group; Genotyping; Southern Thais; Pacific; aleut; Alaska
• Online Access: https://hdl.handle.net/1983/0941c5a1-67b2-41d2-b619-c1d63cd84339; https://research-information.bris.ac.uk/en/publications/0941c5a1-67b2-41d2-b619-c1d63cd84339; https://doi.org/10.1007/s12288-017-0886-9; http://www.scopus.com/inward/record.url?scp=85030844957&partnerID=8YFLogxK

Diego (DI) blood group genotyping is clinically important in Asian populations. Data of Diego blood type among southern Thais is still unknown. This study aimed to report DI*A and DI*B allele frequencies in southern Thai blood donors and to estimate potential risk of Di a incompatibility and alloimmunization in Thai populations. DNA samples obtained from 427 southern Thai blood donors were genotyped for DI*A and DI*B alleles by polymerase chain reaction with sequence-specific primer. DI*A and DI*B allele frequencies among southern Thais were 0.0047 and 0.9953. Their frequencies were similar to those among American Native, Italian, Filipino, Alaska Native/Aleut and Hawaiian/Pacific Islander populations; while, the frequencies significantly differed from central and northern Thai, Southeast Asian, Brazilian, Southern Brazilian, Brazilian Japanese descendants, Japanese, Han Chinese, Chinese, and Korean populations (P < 0.05). The Di a incompatibility among southern Thais (0.93%) was lower than among central Thais (3.49%), corresponding to a significantly lower probability of Di a alloimmunization (P < 0.05). This is the first report of DI*A and DI*B allele frequencies among southern Thais, which is beneficial for not only creating information for estimating risk of alloimmunization, but also providing antigen-negative red cell donors to prevent both alloimmunization and adverse transfusion reactions.