High genetic structuring of Tula hantavirus
Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT...
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ftubpotsdam:oai:kobv.de-opus4-uni-potsdam:45386 2023-05-15T15:56:28+02:00 High genetic structuring of Tula hantavirus Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana Anja Katrin Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer Günter 2016 https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/45386 https://doi.org/10.1007/s00705-016-2762-6 eng eng https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/45386 https://doi.org/10.1007/s00705-016-2762-6 info:eu-repo/semantics/closedAccess Institut für Biochemie und Biologie article doc-type:article 2016 ftubpotsdam https://doi.org/10.1007/s00705-016-2762-6 2022-07-28T20:48:48Z Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas. Article in Journal/Newspaper Common vole Microtus arvalis University of Potsdam: publish.UP Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Archives of Virology 161 5 1135 1149 |
institution |
Open Polar |
collection |
University of Potsdam: publish.UP |
op_collection_id |
ftubpotsdam |
language |
English |
topic |
Institut für Biochemie und Biologie |
spellingShingle |
Institut für Biochemie und Biologie Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana Anja Katrin Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer Günter High genetic structuring of Tula hantavirus |
topic_facet |
Institut für Biochemie und Biologie |
description |
Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas. |
format |
Article in Journal/Newspaper |
author |
Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana Anja Katrin Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer Günter |
author_facet |
Schmidt, Sabrina Saxenhofer, Moritz Drewes, Stephan Schlegel, Mathias Wanka, Konrad M. Frank, Raphael Klimpel, Sven von Blanckenhagen, Felix Maaz, Denny Herden, Christiane Freise, Jona Wolf, Ronny Stubbe, Michael Borkenhagen, Peter Ansorge, Hermann Eccard, Jana Anja Katrin Lang, Johannes Jourdain, Elsa Jacob, Jens Marianneau, Philippe Heckel, Gerald Ulrich, Rainer Günter |
author_sort |
Schmidt, Sabrina |
title |
High genetic structuring of Tula hantavirus |
title_short |
High genetic structuring of Tula hantavirus |
title_full |
High genetic structuring of Tula hantavirus |
title_fullStr |
High genetic structuring of Tula hantavirus |
title_full_unstemmed |
High genetic structuring of Tula hantavirus |
title_sort |
high genetic structuring of tula hantavirus |
publishDate |
2016 |
url |
https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/45386 https://doi.org/10.1007/s00705-016-2762-6 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_relation |
https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/45386 https://doi.org/10.1007/s00705-016-2762-6 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1007/s00705-016-2762-6 |
container_title |
Archives of Virology |
container_volume |
161 |
container_issue |
5 |
container_start_page |
1135 |
op_container_end_page |
1149 |
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1766391881265053696 |