Characterization of a Pseudorabies virus mutant lacking the pUS3 kinase and the tegument protein pUL21 in vitro and in vivo and the evaluation of an improved animal model for human Herpes Simplex Encephalitis

• Main Author: Sehl, Julia
• Other Authors: Institut für Veterinär-Pathologie; Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit, Greifswald - Insel Riems
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Justus-Liebig-Universität Gießen 2020
• Subjects: Agriculture; Langen; Lappen; ren
• Online Access: http://nbn-resolving.org/urn:nbn:de:hebis:26-opus-154804; http://geb.uni-giessen.de/geb/volltexte/2020/15480/

Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and long lasting sequelae such as chronic or relapsi...