Characterization of a Pseudorabies virus mutant lacking the pUS3 kinase and the tegument protein pUL21 in vitro and in vivo and the evaluation of an improved animal model for human Herpes Simplex Encephalitis
Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and long lasting sequelae such as chronic or relapsi...
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Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
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Justus-Liebig-Universität Gießen
2020
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Online Access: | http://nbn-resolving.org/urn:nbn:de:hebis:26-opus-154804 http://geb.uni-giessen.de/geb/volltexte/2020/15480/ |