Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands
Background: Angiostrongylus cantonensis is a lungworm of rats (Muridae) that is the causative agent of human cerebral angiostrongyliasis. The life cycle of A. cantonensis involves rats and mollusks as the definitive and intermediate hosts, respectively. This study was designed to increase the knowle...
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ftubarcepubl:oai:diposit.ub.edu:2445/34208 2024-02-11T10:08:14+01:00 Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands Martin-Alonso, Aarón Foronda, Pilar Quispe-Ricalde, María Antonieta Feliu José, Carlos Valladares, Basilio 2011-11-14 application/pdf http://hdl.handle.net/2445/34208 eng eng Public Library of Science (PLoS) Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0027747 PLoS One, 2011, vol. 6, num. 11, p. e27747 Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) http://dx.doi.org/10.1371/journal.pone.0027747 1932-6203 http://hdl.handle.net/2445/34208 602269 22110752 cc-by (c) Martin-Alonso, Aarón et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Paràsits Nematodes Rosegadors Animals salvatges Immunoglobulines Canàries Parasites Rodents Feral animals Immunoglobulins Canary Islands info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2011 ftubarcepubl https://doi.org/10.1371/journal.pone.0027747 2024-01-24T00:53:49Z Background: Angiostrongylus cantonensis is a lungworm of rats (Muridae) that is the causative agent of human cerebral angiostrongyliasis. The life cycle of A. cantonensis involves rats and mollusks as the definitive and intermediate hosts, respectively. This study was designed to increase the knowledge about the occurrence and distribution of A. cantonensis in its definitive host in the Canary Islands, using parasitological and serological analysis in different areas and age groups.Methodology/Principal Findings: Between 2009 and 2010, 54 black rats (Rattus rattus) from Tenerife were captured from six human-inhabited areas and sera samples were obtained. The lung nematodes were identified by morphological and molecular tools as A. cantonensis. The 31-kDa glycoprotein antigen was purified from A. cantonensis adult worms by electrophoresis and electroelution. Of the 54 tested rodents, 30 showed IgG antibodies against A. cantonensis 31-kDa antigen by ELISA. Therefore, the overall seroprevalence was 55.6% (95% CI: 42.4-68). Seroprevalent rodents were found in all the 6 areas. This 31-kDa antigen was not recognized by some sera of rats infected by other helminth species (but not A. cantonensis). Seroprevalence of IgG antibodies against A. cantonensis and prevalence based on the presence of adult worms showed significant correlation (R2 = 0.954, p,0.05). Conclusions/Significance: The present results could indicate a high prevalence of A. cantonensisin Tenerife and suggest the inclusion of two new zones in the distribution area of the parasite. The commonness and wide distribution of A. cantonensis in rats implies the presence of intermediate hosts, indicating that humans may be at risk of getting infected. Article in Journal/Newspaper Rattus rattus Dipòsit Digital de la Universitat de Barcelona PLoS ONE 6 11 e27747 |
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Open Polar |
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Dipòsit Digital de la Universitat de Barcelona |
op_collection_id |
ftubarcepubl |
language |
English |
topic |
Paràsits Nematodes Rosegadors Animals salvatges Immunoglobulines Canàries Parasites Rodents Feral animals Immunoglobulins Canary Islands |
spellingShingle |
Paràsits Nematodes Rosegadors Animals salvatges Immunoglobulines Canàries Parasites Rodents Feral animals Immunoglobulins Canary Islands Martin-Alonso, Aarón Foronda, Pilar Quispe-Ricalde, María Antonieta Feliu José, Carlos Valladares, Basilio Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
topic_facet |
Paràsits Nematodes Rosegadors Animals salvatges Immunoglobulines Canàries Parasites Rodents Feral animals Immunoglobulins Canary Islands |
description |
Background: Angiostrongylus cantonensis is a lungworm of rats (Muridae) that is the causative agent of human cerebral angiostrongyliasis. The life cycle of A. cantonensis involves rats and mollusks as the definitive and intermediate hosts, respectively. This study was designed to increase the knowledge about the occurrence and distribution of A. cantonensis in its definitive host in the Canary Islands, using parasitological and serological analysis in different areas and age groups.Methodology/Principal Findings: Between 2009 and 2010, 54 black rats (Rattus rattus) from Tenerife were captured from six human-inhabited areas and sera samples were obtained. The lung nematodes were identified by morphological and molecular tools as A. cantonensis. The 31-kDa glycoprotein antigen was purified from A. cantonensis adult worms by electrophoresis and electroelution. Of the 54 tested rodents, 30 showed IgG antibodies against A. cantonensis 31-kDa antigen by ELISA. Therefore, the overall seroprevalence was 55.6% (95% CI: 42.4-68). Seroprevalent rodents were found in all the 6 areas. This 31-kDa antigen was not recognized by some sera of rats infected by other helminth species (but not A. cantonensis). Seroprevalence of IgG antibodies against A. cantonensis and prevalence based on the presence of adult worms showed significant correlation (R2 = 0.954, p,0.05). Conclusions/Significance: The present results could indicate a high prevalence of A. cantonensisin Tenerife and suggest the inclusion of two new zones in the distribution area of the parasite. The commonness and wide distribution of A. cantonensis in rats implies the presence of intermediate hosts, indicating that humans may be at risk of getting infected. |
format |
Article in Journal/Newspaper |
author |
Martin-Alonso, Aarón Foronda, Pilar Quispe-Ricalde, María Antonieta Feliu José, Carlos Valladares, Basilio |
author_facet |
Martin-Alonso, Aarón Foronda, Pilar Quispe-Ricalde, María Antonieta Feliu José, Carlos Valladares, Basilio |
author_sort |
Martin-Alonso, Aarón |
title |
Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
title_short |
Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
title_full |
Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
title_fullStr |
Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
title_full_unstemmed |
Seroprevalence of Angiostrongylus cantonensis in wild rodents from the Canary Islands |
title_sort |
seroprevalence of angiostrongylus cantonensis in wild rodents from the canary islands |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
http://hdl.handle.net/2445/34208 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0027747 PLoS One, 2011, vol. 6, num. 11, p. e27747 Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) http://dx.doi.org/10.1371/journal.pone.0027747 1932-6203 http://hdl.handle.net/2445/34208 602269 22110752 |
op_rights |
cc-by (c) Martin-Alonso, Aarón et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0027747 |
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PLoS ONE |
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6 |
container_issue |
11 |
container_start_page |
e27747 |
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